Posted by admin on Nov 30, 2015 in |
Natural products derived from plants and herbs have always had an important role in drug development. Especially in case of cancer, there is a huge demand for effective chemopreventive and chemotherapeutic agents with natural base and low toxic effects on normal non-cancerous cells. In this work, we have studied the effects of Pistacia atlantica sub kurdica (Baneh) extract on microtubule proteins and their biochemical features. Since microtubules are directly involved in spindle formation and cell division, they can be a very good target for anticancer drugs. We hypothesized that Baneh extract has the potential to inhibit microtubule polymerization and dynamics and as a result inhibit spindle formation during cell division. In order to analyze the effect of Baneh extract on microtubule proteins we decided to investigate these proteins biochemical characteristics in the presence of different concentrations of the extract. We used cell culture model to confirm cytotoxicity of Baneh extract. We then did some polymerization kinetics and dynamics study on microtubule proteins in the presence of various concentrations of...
Read More
Posted by admin on Nov 30, 2015 in |
Inflammation is one of the unique mechanism that help body to protect itself against burn, infection, allergens, toxic chemicals, or other noxious stimuli. It is a defense reaction of the body in order to eliminate or reduce the spread of injurious agent. However, over reaction of the body may be harmful or undesirable. This has resulted in extensive development of anti-inflammatory drugs. Despite the benefits that the drugs hold, it also carries the side effects such as gastric lesions, allergy reactions, tolerance and dependence, as well as resistance. Hence, researchers are working towards ideal medicines of anti-inflammatory with highest efficacy, best potency and lowest or none side effects. This research study evaluates the anti-inflammatory activity of trans-cinnamaldehyde and piperine combination. Preclinical testing of cinnamaldehyde and piperine was done earlier individually on inflammatory models but the combination was not validated for the treatment of inflammation. Therefore, the present study was carried out to evaluate the anti-inflammatory potential of the trans-cinnamaldehyde and piperine combination using carrageenan-induced paw edema model. The combination...
Read More
Posted by admin on Nov 30, 2015 in |
The irreversible effects of modern therapies and increasing drug resistance have augmented our reliance on medicinal plants for herbal remedy against the deadly and infectious diseases. Hypericum perforatum or St. John’s wort (SJW) family Clusiaceae has been used to treat depression, mental disorders, wounds, peptic ulcers, malaria, gout and arthritis. Various compounds of the plant are known as sedative, diuretic and expectorant according to their effects. The flowers and the aerial parts are commonly used in the preparations of traditional medicines. Hypericum perforatum with identified active compounds like Hypericins, Hyperforins is being studied for its anti-depressant activity in both humans and animals. It is also used in the treatment of pulmonary complaints, bladder troubles in suppression of urine, dysentery, worms, diarrhoea, hysteria and other haemorrhages and jaundice. Most of its therapeutic effects with mechanism of action are critically reviewed in the present...
Read More
Posted by admin on Nov 30, 2015 in |
Alzheimer’s disease, the most common cause of dementia is not a normal part of aging and worsens over time. The most common early symptom of Alzheimer’s is difficulty remembering newly learned information. Microscopic changes in the brain begin long before the first signs of memory loss. Two abnormal structures called plaques and tangles are prime suspects in damaging and killing nerve cells. Currently, there are five FDA-approved drugs that treat the symptoms of Alzheimer’s disease — temporarily helping memory and thinking problems in about half of the people who take them. But these medications do not treat the underlying causes of Alzheimer’s. In contrast, many of the new drugs in development aim to modify the disease process itself, by impacting one or more of the many wide-ranging brain changes that Alzheimer’s causes. These changes offer potential “targets” for new drugs to stop or slow the progress of the disease. Today, there is a worldwide effort under way to find better ways to treat the disease, delay its onset, and...
Read More
Posted by admin on Nov 30, 2015 in |
Candesartan cilexetil, a prodrug is a racemic mixture containing one chiral center at the cyclohexyloxy-carbonyloxy- ethyl ester group. It is soluble in dimethyl formamide, acetone, methanol, 0.1 N sodium hydroxide solution and insoluble in water. Objective of the present study is to develop a simple, sensitive, accurate, precise and rapid derivative spectrophotometric method for the estimation of candesartan in pure form. For the estimation of candesartan, solvent system employed was absolute methanol and wavelength of detection (λdet) was 294.3 nm for third order derivative spectroscopy. The linearity was obtained in the range 180 – 280 µg/ml. The regression equation was found to be y = 0.0001x + 0.003 & regression coefficient, R2 was found to be 0.999. The limit of detection is 6.7µg/ml and limit of quantification was fund to be 20.4 µg/ml. Obtained results showed that there is minimum intraday and inter day variation. The developed method was validated and recovery studies were also carried out. Sample recovery using the above method was in good agreement with their...
Read More
