Posted by admin on Nov 30, 2015 in |
Polysaccharides obtained from gums and mucilages are extensively used natural materials for conventional and novel dosage forms. Many natural gums are studied for use in novel drug delivery systems out of which polysaccharides, resins and tannins are most extensively studied and used. Because of advances in drug delivery technology, natural polysaccharides are included in novel drug delivery to fulfil multitask functions and in some cases directly or indirectly control the extent or rate of drug release. Regular research is going on in the field of use of naturally occurring biocompatible polymeric material in designing of dosage forms for oral controlled release administration. The natural polysaccharides improve the national economy by providing inexpensive formulations to people, by using locally available materials. The present review covers almost all the areas of interest of some very important naturally based polysaccharides, natural gums and mucilages with their sources, chemical constituents, chemical structures, isolation, purification, standardization and characterization along with their uses in various pharmaceutical...
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Posted by admin on Nov 30, 2015 in |
Sugarcane is the major cash crop of the Indian tropical and sub-tropical region. Mostly the foremost part of Indian economy is based on sugarcane crop, which is cultivated major state in India. Phyto-components are the compound that occurred in plant naturally and play important role for biologically activity (Anti fungal, Anti cancer Anti diabetic etc), to prevent the many disease, scavenging and chelating the free radicals. In the present study we identified the phytocomponent presence in juice sample of Mungo 254 (Saccharum barberi) through GC-MS analysis. The major compound sucrose (30.64%) with retention time 12.18 and lower percentage compound was Pentanal, 2-methyl (0.10%) with 6.48 retention time. The identified compounds having biological and pharmacological activity such as Antimicrobial, Antifungal, Anticancer, Antioxidant, Antimutagenic and Hypercholesterolemic...
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Posted by admin on Nov 30, 2015 in |
High performance thin layer chromatographic method has been developed for the determination of Olopatadine (OLO) and Montelukast (MONT) in their combined dosage form. Merck HPTLC aluminum plates of silica gel G60 F254, (10 × 10 cm) was used for separation of combined with 250 μm thickness using Chloroform: Ethyl acetate: Methanol: Triethylamine (6: 4.5: 2.5: 0.8, v/v/v/v) as mobile phase. HPTLC separation of the both drugs were carried out and followed by densitometric measurement was performed in the absorbance mode at 254 nm. The drugs were resolved satisfactorily with Rf values of 0.39 ± 0.01 and 0.66 ± 0.01 for OLO and MONT, respectively. The developed method was validated in terms of accuracy, precision, linearity, limit of detection, limit of quantification and robustness. The developed HPTLC method can be applied for identification and quantitative determination of OLO and MONT in bulk drug and drug...
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Posted by admin on Nov 30, 2015 in |
A simple, precise, and robust spectrophotometric method for the determination of Cefotaxime sodium has been investigated and validated. The proposed chemical reaction involves the reaction of primary amine of Cefotaxime sodium with nitrite solution in acidic medium to form a diazotized product, followed by the reaction of the diazotized product with suitable coupling reagent resulting in a colored product. Cefotaxime sodium has shown λmax 500nm. The method was found linear obeying Beer Lambert law at concentration range of 1-20 ppm. In the method detection limits was observed 0.744 ppm with quantification limit of 2.48 ppm and standard deviation of 0.248. In the present work an attempt was made to develop a simple, less expensive and more reliable method for the determination of Cefotaxime sodium in pure and pharmaceutical...
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Posted by admin on Nov 30, 2015 in |
Etoposide is an antineoplastic agent employed for healingvarious malignancies in human. It is a semi-synthetic derivative of podophyllotoxin and was introduced in 1971. The primary mode of action of etoposide is the inhibition of the function of the enzyme topoisomerase II. It stabilizes DNA-enzyme complex, and accumulation of this complex enhances the probability of double-stranded DNA breaks. However, etoposide can also causes DNA lesions in cancerous cells. This genotoxicity and antineoplastic activity of drug at the same time serve as the impetus for intensive research. Etoposide treatment causes permanent DNA breaks pertaining to its significant role in cell death and growth arrest in tumor cells. This review attempts to provide the deep knowledge of its possible biochemical pathways which are triggered in response to DNA breaks and leads to apoptosis and cell cycle arrest as well transcriptional activation of various death receptors. Molecular mechanism of drug efflux and activation of repairing proteins which can cause resistance in its action are also discussed. This current picture of known facts serve...
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