Posted by admin on Mar 1, 2011 in |
Post stroke depression is most commonly faced psychiatric challenge, causing severe disability. Post stroke depression (PSD) occurs in nearly one-third patients either during acute/chronic stroke period. It’s often under-diagnosed. A good diagnosis must be done within one month after stroke, based on self-reporting tools, followed by observer-rated interview. Mechanism is multifactorial, presently best supported by biopsychosocial model. Upcoming approaches are genetic based and cytokine theory. About 10% PSD patients face mortality. There is a huge negative biological and psychosocial impact of PSD. Currently, pharmacological and non-pharmacological way-outs are used to manage the PSD. However, precise and timely done evaluation aided by proper therapy and utmost care is also required, under the supervision of a multidisciplinary health...
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Posted by admin on Mar 1, 2011 in |
Many drugs exist in crystalline solid form due to reasons of stability and ease of handling during the various stages of drug development. Crystalline solids can exist in the form of polymorphs, solvates or hydrates. Phase transitions such as polymorph inter-conversion, formation of hydrates, desolvation of solvates, and conversion of the crystalline to amorphous form may occur during various pharmaceutical processes. This could change the dissolution rate and transport characteristics of the drug. The current focus of research in the area is to understand the origins of polymorphism at the molecular level, and to predict and prepare the most stable polymorph of the drug. The aim of this review is to understand the recent development in the area of solid state crystallinity, amorphous state and to address the current challenges faced by pharmaceutical formulation, process development scientists and to anticipate future...
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Posted by admin on Mar 1, 2010 in |
In view of the ethanobotanical and traditional claims of Anthocephalus cadamba plant used as hypoglycemic agent and wide use of its bark, fruits and leaf extract in anti-diabetic activity. Methanolic extract of Anthocephalus cadamba bark in alloxan induce hypoglycemia in rats. In glucose loaded normal rats, hypoglycemia was observed maximum at 120 minutes after administration of ACBE (Anthocephalus cadamba bark extract). Single dose administration of ACBE produce significant hypoglycemic effect in alloxan induced diabetic rats. The present study indicates that the methanol extract of barks posses anti-diabetic properties which suggest the presence of biologically active components. The extract might be promoting glucose uptake and metabolism or inhibiting hepatic gluconeogenesis. Result from the phytochemical analysis of Anthocephalus cadamba revealed the presence of flavonoids, which has also been isolated from the other plant and found to stimulate secretion or possess an insulin-like effect....
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Posted by admin on Mar 1, 2010 in |
Jatropha curcas L. and P. pinnata Pierre is gaining importance as biodiesel crop in India. Jatropha curcas L. a member of the family Euphorbiacea and Pongamia pinnata, a member of the family Leguminoseae. A study was conducted to identify common arbuscular mycorrhizal fungi present in its rhizosphere from different regions of India viz., Jodhpur (Rajasthan), Hissar (Haryana), Jhansi and Lalitpur (Uttar Pradesh) and Hyderabad (Andhra Pradesh). The results showed that different AM fungal species were present at different locations. A total of five Acaulospora AM species were recorded in different location of India. The highest frequency of occurrence was recorded for Acaulospora scrobiculata Trappe (100%), minimum frequency of occurrence was observed in A. mellea in J. curcas. The highest frequency of occurrence was recorded for Acaulospora scrobiculata Trappe (75%), Moderates frequency of occurrence was observed in A. mellea in P. pinnata. Maximum species richness was recorded at Jodhpur, followed by Jodhpur, Hissar, Hydrabad, Jhansi, Lalitpur, and Pantnagar. Isolation of five species of Acaulospora species (A. dilatata (Morton), A. denticulata ...
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Posted by admin on Mar 1, 2010 in |
Butea monosperma (Fabaceae) is distributed all over India and has been used by triable as well a local people widely. Locally it is known as “Markundi” and a cool infusion of the flowers is taken in the treatment of diabetes among the Sahariya of Northwest M.P. Butea monosperma is used in the treatment of leprosy, gout, diarrhea, anti-inflammatory, diuretic and leucorrhoea. In the present work the alcoholic and aqueous extracts of leaves of Butea monosperma were evaluated for its anthelmintic activity against adult earthworms (Phertima prosthuma). The activities of the extracts were compared with standard Albendazole. Both the extracts and standard were prepared in saline water. The alcoholic and aqueous extract of the leaves showed significant anthelmintic activity and it was found that the aqueous extract activity is higher than alcoholic...
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