Posted by admin on Feb 28, 2026 in |
Medicinal flora is essential for the preservation of human existence. Many people believe that herbs, in their natural medicinal state, are a gift from God to humanity. The use of herbal remedies has skyrocketed in the past few decades. Nearly seven thousand five hundred species make up the vast family Euphorbiaceae. The Ricinus communis plant, more often known as castor oil, is abundant in India, typically growing wild on abandoned lots, and it has great traditional and therapeutic use for promoting health and warding off illness. Other names include “wonder tree” or “Palma Christi,” are similar. Bark, leaves, blossoms, seeds, oil, and other component of a plant is valuable. Ayurveda, Unani, Homeopathy, and Allopathy all make heavy use of this plant’s oil as a cathartic. As a purgative, resolvent, anti-arthritis, anti-inflammatory, analgesic, emmenagogue, antidote for Datura poisoning, anti-dysenteric, and many more medicinal uses, this plant also has beneficial effects as an antioxidant, antiulcer, immunomodulatory, antidiabetic, hepatoprotective, antimicrobial, stimulant of the central nervous system, wound healer, antifertility, and many more....
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Posted by admin on Feb 28, 2026 in |
Lower Respiratory Tract Infections (LRTIs) remain a major cause of morbidity and mortality, especially in rural healthcare settings where diagnostic limitations influence antibiotic prescribing behaviour. Aim: To evaluate the prescription pattern and antibiotic utilization among patients diagnosed with Lower Respiratory Tract Infections (LRTIs) in a rural hospital setting and to assess the rationality of antibiotic use based on WHO and ICMR guidelines. Objective: To identify the types of antibiotics prescribed, determine the proportion of broad- and narrow-spectrum agents, and assess adherence to rational prescribing practices in a government-managed rural hospital. Methodology: A prospective observational study was conducted at a rural hospital in Latur, Maharashtra, from August 2024 to March 2025. Fifty patients clinically diagnosed with LRTIs were enrolled. Data were collected using a structured form and analysed using WHO prescribing indicators to evaluate antibiotic utilization patterns and supporting medications. Results: Out of 50 prescriptions analysed, 81% contained broad-spectrum antibiotics, while only 19% contained narrow-spectrum agents. Cephalosporins and β-lactam/β-lactamase inhibitor combinations were most frequently used. Supportive drugs such as pantoprazole,...
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Posted by admin on Feb 28, 2026 in |
Background: Diabetes mellitus (DM) is a dangerous metabolic illness that causes blood glucose levels to rise unnaturally. This is brought on by problems with insulin secretion, which controls how the body uses glucose to make energy. The two main types of diabetes mellitus (DM) are Type 1 DM and Type 2 DM. Type 1 Diabets Mellitus (T1DM), which is brought on by a complete or nearly complete lack of insulin, and Type 2 Diabets Mellitus (T2DM), which is defined by insulin deficiency or insulin resistance. In order to control hyperglycemia for T2DM hyperglycemic drugs. Insulin therapy is also used as an alternative for patients who show allergic reactions to oral hyperglycemic drugs. The aim of this paper is to review phytochemical constituents and antidiabetic activities of selected medicinal plants (Otistiga integrigolia, Moringa stenopetala, Sativa rabaudiana rabaudiana, Meriandra dianthera, indica, Momordica charantia, Allium sativum, and Ajuga remota) from Ethiopian flora. Methods: This review article is intended to compile information already available on selected Ethiopian medicinal plants of active compounds and...
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Posted by admin on Feb 28, 2026 in |
The current research was conducted to compare the acute oral toxicity, analgesic and anti-inflammatory properties of ethanolic extracts of Phytanthus fraternus and Impatiens balsamina, two medicinal plants that have been used traditionally in treating pain and inflammation. The acute toxicity was evaluated in Swiss albino mouse based on the OECD guideline 423 at a dose of 300 mg and 2000 mg/kg. There were no mortalities, abnormal behaviour or adverse clinical effects, which categorised the two extracts as the Globally Harmonised System (GHS) Category 5. To assess analgesic activity, the acetic acid-induced writhing test was used on mice, whereas anti-inflammatory potential has been assessed using both in-vitro and in-vivo models: the human red blood cell (HRBC) membrane stabilisation assay and carrageenan-induced paw oedema in rats, respectively. Findings revealed that both extracts had marked, dose-dependent analgesic and inflammatory effects, with the extract of P. fraternus having a uniformly higher potency than I. balsamina. Their stabilising behaviour against hypotonicity-induced haemolysis, an indicator of membrane-stabilising and anti-inflammatory activities, was confirmed with the HRBC...
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Posted by admin on Feb 28, 2026 in |
High-Altitude Illness (HAI) refers to a spectrum of hypoxia-related syndromes occurring above 2,500 meters, ranging from mild acute mountain sickness (AMS) to life-threatening conditions like high-altitude cerebral edema (HACE) and pulmonary edema (HAPE). With the rise in trekking, tourism, and military operations in high-altitude regions, HAI has emerged as a significant public health concern. AMS typically develops within 6–12 hours of ascent, presenting with headache, dizziness, nausea, fatigue, and disturbed sleep. If untreated, AMS can progress to HACE, characterized by ataxia, altered mental status, and coma, or to HAPE, marked by dyspnea, cough, cyanosis, and pulmonary crackles. The underlying mechanisms include cerebral vasodilation, oxidative stress, and blood–brain barrier disruption in AMS/HACE, while HAPE results from abnormal hypoxic pulmonary vasoconstriction and alveolar-capillary leakage. Diagnosis is primarily clinical, with the Lake Louise Score being the most widely used tool despite field limitations. Prevention relies on gradual acclimatization, staged ascent, and avoidance of alcohol or sedatives, which improve ventilatory and hematologic adaptation. Pharmacologic options like acetazolamide, dexamethasone, and nifedipine may be useful...
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