Posted by admin on Feb 28, 2017 in |
Introduction: Wrightia arborea (Apocynaceae) has been used in traditional medicine to treat ailments such as menstrual and renal complaints, snake-bites, tooth-ache and diarrhea. Objective: This study aimed to evaluate the phytochemical constituents, antioxidant, antimicrobial and antiproliferative activities of W. arborea leaf extracts. Materials and Methods: Total phenolic and flavonoid contents of the leaf extracts were determined. The antioxidant activity of the extracts were investigated using DPPH, ABTS, nitric oxide scavenging assays, phosphomolybdenum assay, reducing power and metal chelating assay. Antimicrobial activity was tested against MTCC strains and MDR clinical bacteria. The antiproliferative activity was determined using MTT assay against three cancer cell lines. Results: Extracts showed high total phenolic content ranging from 85.7± 1.15 to 40.3± 0.6 gallic acid equivalents and flavonoid content ranging from 750±5.5 to 140±3.6 quercetin equivalents per gram of dry extract. Ethyl acetate extract showed highest DPPH scavenging activity with an EC50 value of 330μg/ml. The antimicrobial effects of all the extracts were found to be genus specific – only against Klebsiella spp. The chloroform...
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Posted by admin on Feb 28, 2017 in |
Aim: The study was done to evaluate the antibacterial and antifungal activity of the leaves of Colocasia esculenta Linn. Materials and Methods: Fresh tender leaves of C.esculenta collected, air-dried at room temperature, grounded to a fine powder and extracted with ethanol. The antibacterial and antifungal activity of C.esculenta compared to standard antibiotics was assessed by disc diffusion method by measuring the zone of inhibition. The organisms used for the test were Staphylococcus aureus, Klebsiella, Escherichia coli and Pseudomonas aeruginosa and Candida albicans. The agar disc diffusion method described by Kirby-Bauer was used for testing the antibacterial and antifungal activity. Results: Zone of inhibitions produced by sensitive organisms were demarcated by a circular area of clearing around plant extract impregnated discs and measured in millimeter (mm). Mean ± SEM was calculated and the data was statistically analysed by one way ANOVA followed by Dunnets multiple comparison test. Conclusion: In our study, ethanolic extract of Colocasia esculenta showed antibacterial activity against S. aureus, P. aeruginosa, E.coli, Kleibsiella and antifungal activity against...
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Posted by admin on Feb 28, 2017 in |
Nanobiomaterials are very effective components for several biomedical and pharmaceutical studies. Among the metallic, organic, ceramic and polymeric nanomaterials, metallic nanomaterials have shown certain prominent biomedical applications. Enormous works have been done to synthesize, analyse and administer the metallic nanoparticles for various kinds of medical and therapeutic applications, during the last forty years. In these analyses, the prominent biomedical applications of ten metallic nanobiomaterials have been reviewed from various sources and works. It has been found that almost nine of them are used in a very wide spectrum of medical and theranostic...
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Posted by admin on Feb 28, 2017 in |
The human skin serves as an impediment, a thermo regulator and prevents excessive loss of water from the internal organs. Various ways of transferring the drugs have been developed by modifying the barrier properties of the skin. Enhancement in skin penetration by hydration of the stratum corneum, or by use of chemical enhancers acting on the lipids and keratinized structures in the stratum corneum, partitioning and solubility effects is a promising tool in potential clinical applications. Penetration enhancement is a new emerging technology which has the potential to increase the number of drugs taken trans-dermally. Also the drugs with short biological half-life could be easily administered. Among many advantages over other routes the three crucial ones are avoiding metabolism in liver, minimal negative effects and increased bioavailability. Also, the stratum corneum prevents the loss of physiologically essential substances and as a result provides penetration resistance by acting as a protective barrier. This is the rate limiting step in the absorption of the drug percutaneously. In this review article, we...
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Posted by admin on Feb 28, 2017 in |
The studies on tree biomass for assessing carbon density in tropical forest ecosystem of central India was undertaken during 2009-11 in forest area of eight districts [Jabalpur, Seoni, Balaghat, Narsinghpur, Mandla, Dindori, Shahdol and Umaria] at 30 adopted representative sites at varying latitudes and longitudes. The annual rainfall of their study area was 1000-1600 mm. The soils of the study sites were alluvial, light to medium black as well as red and yellow with pH value ranging from 5.5 to 80. The study was confined in three vegetation type viz., teak mixed, salmixed and mixed forest. In the study new approach was adopted by using ground data as well remote sensing data to get an accurate estimate of vegetation carbon pool in the region. Among the 30 selected site ID, Tectona grandis was dominated at 10 side. The basal area and volume of tree species in forest study sites ranged between 0.8 to 169.68 m2/ha and 0.11 to 2, 31299.82 m3/ha. The maximum tree biomass/ha recorded for Shorea roubsta...
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