Posted by admin on Apr 1, 2010 in |
Over the past decade, herbal and ayurvedic drugs have become a subject of world importance, with both medicinal and economical implications. A regular and widespread use of herbs throughout the world has increased serious concerns over their quality, safety and efficacy. Thus, a proper scientific evidence or assessment has become the criteria for acceptance of herbal health claims. In the present study we examined the antioxidant effects of ethanolic extract of leaves of Clerodendrum infortunatum Linn at various concentrations in the DPPH radical scavenging assay, FRAP assay (Ferric Reducing Antioxidant Power) and the Hydrogen peroxide radical scavenging assay. The results of the present study revealed that the plant extract has significant antioxidant activity and are encouraging for further assessment to elucidate the mechanism of action and to identify the bioactive compounds implicated in the antioxidant effect and the membrane-stability....
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Posted by admin on Apr 1, 2010 in |
Metoprolol tartrate which is used in the present study is widely used as antianginal properties. Oral bioavailability of metoprolol tartrate is around 40%. In the present work fast dissolving tablets of metoprolol tartrate have been prepared by direct compression method. Formulations were evaluated for precompressional parameters such as angle of repose, % compressibility and Hausner’s ratio. The prepared tablets were evaluated for post compressional parameters such as hardness, friability, thickness, in-vitro dispersion time, wetting time, and water absorption ratio. The prepared tablets were characterized by DSC and FTIR studies. Stability studies were carried out as per ICH guidelines for three months. Effect of superdisintegrants [such as croscarmellose sodium, sodium starch glycolate, crospovidone, and Indion 414] on wetting time, in-vitro dispersion time and stability parameter has been studied. In-vitro dispersion time decreases with increase in concentration of indion 414 upto 9% then increases. Where as in-vitro dispersion time decreases with increase in the concentration of croscarmellose sodium and in-vitro dispersion time increases with increase in concentration of sodium starch glycolate....
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Posted by admin on Apr 1, 2010 in |
Mentha piperita, a commercially important medicinal plant, yields essential oils. The oil extracted by steam distillation, gives two types of waste products viz. high boiling hydrosol and bottom pitch, which sell at a very low price. Some constituents of the waste products are useful in perfumery industry and they also exhibit medicinal activities such as anti-inflammatory. The aim of present study is to characterize the value adding constituents from the target products by saponification followed by hydro- distillation....
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Posted by admin on Apr 1, 2010 in |
Dendrimers are a new class of polymeric materials. They are highly branched, monodisperse macromolecules. Structural Advantages allow dendrimers to play an important role in the fields of nanotechnology, pharmaceutical and medicinal chemistry. As a result of their unique behaviour dendrimers are suitable for a wide range of biomedical and industrial applications. The paper gives a brief review of dendrimers’ physico-chemical properties and their possible use in various areas of research, technology and...
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Posted by admin on Apr 1, 2010 in |
More than 50% of pharmaceutical products are orally administered for several Reasons and undesirable taste is one of the important formulation problems that is Encountered with such oral products. Taste of a pharmaceutical product is an important parameter governing compliance. Hence taste masking of oral Pharmaceuticals has become important tool to improve patient compliance and the Quality of treatment especially in paediatrics. Different methods have been suggested for Masking of taste of bitter drugs, which includes, coating of drug particles with inert agents, taste masking by formation of inclusion complexes, molecular complexes of drug with other chemicals, solid dispersion system, microencapsulation, multiple emulsions, using liposome’s, Prodrugs and mass extrusion method but ion exchange resin is one of most extensively Used method to overcome this problem. Ion-exchange resins (IER) have received considerable attention from pharmaceutical scientists because of their versatile properties as drug-delivery vehicles. In the past few years, IER have been extensively studied in the development of novel drug-delivery systems (DDSs) and other biomedical applications. Also Recently the New...
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