Posted by admin on Mar 31, 2023 in |
The current study aims to develop a reversed-phase HPLC method for quantifying the active substances of Fenticonazole Nitrate (FENTI), Tinidazole (TINI) and Lidocaine base (LIDO) simultaneously and to validate the proposed method for the intended analytical application in the bulk and pharmaceutical dosage form by ICH guidelines. In this work, the behaviour of f FENTI, TINI and LIDO was studied under various degradative conditions, and a stability-indicating LC method was developed to separate the degradation products and quantify the drug in their presence. The mobile phase Phosphate buffering agent: Methanol: Acetonitrile (60:30:10; v: v: v), Hypersil Phenyl type silica column, with flow rate 1.0ml, detection wavelength 210nm, column temperature at 40ºC and Methanolis used as diluents. System Suitability, Specificity, Precision, Linearity, Accuracy, and Robustness parameters were all validated. The system suitability parameters were investigated by injecting the standard six times, and the results were well below the acceptance threshold. Linearity parameter was investigated at levels ranging from 80% to 120%, with a r2 value of 0.999 discovered. The formulation...
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Posted by admin on Mar 31, 2023 in |
The preparation of metal-based Indian traditional drugs involves the conversion of pure metal into its therapeutically effective form. “Tamra Bhasma” (calcined copper) is one such herbometallic preparation used for various medical conditions like anaemia, obesity, and skin disease, disorders of the liver and spleen, hyper-acidity, rhinitis, hemorrhoids. A detailed evaluation of the changes occurring during each step of pharmaceutical processing, factors affecting the type of Puta and its physicochemical characterization has been examined in the present work. The pharmaceutical preparation of “Tamra Bhasma” (TB) includes quenching in liquid media, then boiling in liquid, followed by calcination and finally to remove the leftover blemishes, potentiation is carried out. Traditional Puta (the process of controlled heating and cooling) system has been used for its calcinations and Kajjali and Gandhaka have been used as media for calcinations of Tamra. TB has been subjected to different physicochemical characterization using XRD and SEM-EDXA. The result suggests that Bhasma Parikshas (confirmatory tests) are the most reliable criteria to authenticate the formation of a good quality...
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Posted by admin on Mar 31, 2023 in |
Herbal medicine (also herbalism) is the study of pharmacognosy and the use of medicinal plants, which are the basis of traditional medicine. Any damage or break in the surface of the skin is a wound. In Soxhlet extraction, solvent extraction involves extraction with solvents of increasing polarity from a nonpolar to a more polar solvent to ensure that a wide polarity range of compounds can be extracted. 1 % of the extract was incorporated in the preparation of gel formulation using Carbomer 940 polymer as gelling agent. Three formulae 1, 2 and 3 of gel containing varying concentrations of Carbomer 940(0.5, 1 and 1.5%) were prepared. Carbomer 940 was soaked in distilled water overnight. Selected extracts were dissolved in ethanol. Standard methods and results examined different Physicochemical evaluation parameters of formulated ointments were found within the acceptable limits. Cissampelos Pareira Vein-islet number/mm2 was 3.6 and it ranges from 3.5 to 3.9. the Palisade ratio was 3, and it ranges from 2.75 to 3.75. The Stomata length (µm) was found...
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Posted by admin on Mar 31, 2023 in |
Cosmetic products are produced by the most inventive and technically driven methods to reach more consumers in the developing world. Cosmetic products are also regulated, similar to pharmaceutical products. BRICS countries are emerging markets with a partial regulatory system similar to well-regulated countries. BRICS countries have a registration or notification process for cosmetics based on their classification. A systematic review was carried out. We searched the databases and reviewed assessment agency websites, among other sources. Qualitative studies, official regulations, and systematic reviews aimed to identify a general framework of regulatory activity in BRICS were included. A critical analysis is made of all the aspects that may be useful for any public body that intends to register cosmetics in any of the BRICS countries. BRICS nations are organized to promote, stabilize and consistently regulate cosmetic products among them. The cosmetic regulatory system, registration process, and procedures of South Africa are at their last position, as Russia precedes South Africa. Cosmetic products are very well regulated and the registration process is...
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Posted by admin on Mar 31, 2023 in |
Omega-3 fatty acids are essential fatty acids present in regular animal and plant food diets. They play a key role in different body functions. Omega-3 fatty acids help to prevent central nervous system diseases. In this paper, we have shown the molecular basis of this effect. There isa number of studies showing the role of omega-3 fatty acids in the prevention of different central nervous system disorders. Omega-3 fatty acid plays a key role in brain development even during embryogenesis. It mainly shows a preventive effect against CNS disorders due to its anti-inflammatory action. Parkinson’s disease, migraine, schizophrenia, dementia and psychosis are some of the most abundant CNS disorders which are difficult to cure completely, especially in advanced stages. Omega-3 fatty acids, which can be obtained from a regular diet plan, have the potential to prevent and sometimes cure these disorders. Although in some cases the appropriate database is not available, all in all, it can be said that omega-3 fatty is plays a preventive role in most CNS...
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