Posted by admin on Mar 31, 2021 in |
The purpose of the present work was to prepare and evaluate olmesartan-loaded non-ionic surfactant vesicles (niosomes) to get sustained release by increasing the solubility and bioavailability. Ether injection and thin-film hydration methods were used for the preparation of all formulations as per the factorial design to study the effect of the three independent variables X1 (amounts of span 60), X2 (amount of cholesterol) and X3 (amount of chitosan/ PEG-6000) on two dependent variable Y1 (% DEE), and Y2 (% CDR), respectively. Prepared niosomes were characterized by % DEE, % CDR, FTIR, SEM, and zeta potential, etc. Statistical analysis was performed using ANOVA, and optimization was done by fitting experimental data. After 8 hours dissolution, the minimum and maximum cumulative drug release were observed to be 75.90% and 85.91%, and 77.32% and 88.74% for SPEIM-2 and SPEIM-1 and CHEIM-2 and CHEIM-1; 80.24% and 86.11% and 80.11% and 90.72% for SPTFH-2 and SPTFH-1, and CHTFH-7 and CHTFH-1, respectively. Data obtained from in-vitro dissolution tests were fitted to different kinetic models. FTIR...
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Posted by admin on Mar 31, 2021 in |
The present study was to estimate the total phenolic content, flavonoids content and evaluate the in vitro antioxidant activity of alcoholic and aqueous extract of the leaves of plant Mimusops elengi Linn. Total phenolic content was determined calorimetrically using Folin ciocalteu reagent, and Total flavonoid content was determined by aluminum chloride method. The total phenolic content of methanol, ethyl acetate soluble fraction, and aqueous extract was found 23.22, 22.44, and 15.88%w/w respectively. In the case of total flavonoid content was found 33, 31, and 24%w/w respectively. Antioxidant activity was measured based on the DPPH radical scavenging assay, Nitric oxide scavenging assay, and reducing power assay. A methanol extract of the leaves of the plant showed potent free radical scavenging activity with an IC50 value of 65.00 μg/ml. However, standard ascorbic acid activity was significantly higher than that of all extracts. The IC50 value of the standard (Ascorbic acid) was 7.779μg/ml. In the case of nitric oxide scavenging assay, the methanolic & aqueous extract of the leaves of the plant...
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Posted by admin on Mar 31, 2021 in |
India is renowned for its rich biodiversity and the Western Ghats, because of its varied topography and ecological conditions support a very rich flora including medicinally valuable aromatic and non-aromatic plant species. The Western Ghats are additionally documented for diversity within the ethnic communities; they have been utilizing the plant wealth for medicinal purposes and have proven successful for generations. Coleus, one of the largest genus of the family Lamiaceae, is well known for its aromatic medicinal plants of ethnomedicinal importance. Among the different species within the genus, Coleus amboinicus and Coleus barbatus are the most documented species with a wide variety of traditional medicinal uses in ayurvedic as well as folklore medicine. Even though the plants such as Coleus malabaricus, Coleus mollis, Coleus urticifolius, Coleus fruticosus, Coleus bishopianus, Coleus paniculatus and Coleus caninus of the Western ghats reported to possess enormous ethnomedicinal uses, very little is known regarding the chemical constituents and biological activities of these species. Numerous new species have additionally been recognized from this area. This...
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Posted by admin on Mar 31, 2021 in |
Herbal Medicinal Products are gaining acceptance among people across the world due to rising awareness of lifestyle diseases and improper food habits. During the latter part of the twentieth century, increasing interest in self-care resulted in enormous growth in the popularity of traditional healing modalities, including the use of Herbal remedies. Side effects caused by the use of modern medicines are driving consumers towards herbal medicines and their supplements and this is driving the growth of Herbal Medicines across the world. Herbal Medicines, when sold commercially, should comply with country-based regulations concerning safety, quality, and efficacy. At present regulations for herbal medicines differ country-wise. Due to this, herbal medicine companies cannot manufacture a standard product for the global market. Hence a concerted effort should be undertaken by global regulatory authorities and agencies like WHO to establish a uniform and harmonized regulation for herbal medicines. In this paper, we highlighted various challenges and constraints in manufacturing as well as the marketing of herbal medicinal products across the...
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Posted by admin on Mar 31, 2021 in |
By the HPTLC method, a mobile phase system comprising of Ethyl acetate: Toluene: Methanol (5:4:1v/v/v) was selected, and the detection was carried out at 280 nm. The Rf values were found to be 0.65 ± 0.03 and 0.27 ± 0.03 for Mebendazole and Atorvastatin, respectively, which showed a good separation. The method was validated as per ICH guidelines. The percentage RSD values of repeatability, intraday, and interday were found to be less than 2 prove the precision of the method. The correlation coefficient value from the calibration graph was found to be 0.9949 for Mebendazole and 0.9979 for Atorvastatin. The percentage protein binding of Mebendazole and Atorvastatin was estimated by the equilibrium dialysis method. The in-vitro displacement interaction study was carried out using standard solutions of a mixture containing 1.5×10-4 M Mebendazole and Atorvastatin along with 1.5×10-4 M BSA. The percentage protein binding of individual Mebendazole and Atorvastatin after 6hr was found to be 86.14% and 91.18%, respectively. While they were evaluated in the presence of each other, the...
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