Posted by admin on Mar 31, 2017 in |
N-mannich bases of benzimidazole derivatives can work against convulsions. Docking used for virtual screening of database and for the prediction of the strongest binders based on various scoring functions. Docking studies were carried out on different benzimidazole derivaties for better anticonvulsant activity which is important for the development of new class of inhibitors. Protein–ligand interaction plays an important role in structural based drug design. In our research we selected different receptors. The receptors were docked with different imidazole derivatives and the energy values were obtained. Our study reveals that highest minimal energy values were observed with receptors like 4NF8, 4JWY, 4JWX, 3QEK, 3OEK, 3OEL, 3OEM, 3OEN. The results suggests that N-mannich bases of benzimidazole derivatives might be a potential targets of NMDA receptors for effective anticonvulsant...
Read More
Posted by admin on Mar 31, 2017 in |
Aloe vera has been used since ages to manage a number of diseases causing pain, inflammation and fever. However, its effectiveness has not been scientifically certified. NSAIDs & Opioid are used continuously for the pain management. Alternative analgesics are needed to escape from the serious adverse effects of NSAIDs. Our study demonstrated significant analgesic activity of Aloe vera at doses of 200 mg/kg and 500 mg/kg. Materials and Methods: The study was carried out using Wistar Albino rats (150-200gm). Soxhlets apparatus was used to prepare the aqueous extract of Aloe vera [AEAV]. The animals were divided into 4 groups (n=6) receiving different treatments. Hot plate method, acetic acid induced writhing method and tail flick tests were used. The results were subjected to statistical analysis by using one way ANOVA followed by Dunnett’s test. Results Analgesic effect of high dose of AEAV at 500 mg/kg was similar with the standard drug indomethacin. The extract (200 & 500 mg/kg) exhibited a dose-dependent inhibition of writhing and also showed a significant (P...
Read More
Posted by admin on Mar 31, 2017 in |
The aim of present study is to improve the aqueous solubility of valsartan by utilizing hot melt extrusion technique (HME). Hot melt extrudates were prepared by novel polymeric matrices such as HPMCAS and Plasdone S630 copovidone at different ratios. The solubility studies of extrudates, showed a significant improvement in aqueous solubility. Gastroretentive floating tablets of valsartan using its extrusion complex with plasdone S630 copovidone were formulated by, direct compression method. The tablets comprised of HPMC K4M, HPMC K15M, as release retarding polymers to control the drug release. Preliminary trials applied to optimize the drug release profile. A 10.5 fold increase in the solubility of valsartan was observed with valsartan: plasdone S630 copovidone complex in the ratio of 1:2. Trial batches of tablets showed best results for formulation F3 (20% HPMC K15M and pregelatinized starch 12%) released 99.41% of valsartan in 20 h, with desired floating lag time (18 sec) and constantly floated on dissolution medium for more than 24 h. Accelerated stability studies were conducted at 40±2 ºC temperature...
Read More
Posted by admin on Mar 31, 2017 in |
Antianaphylactic activity of Withania somnifera was investigated by using rat peritoneal mast cells. The investigation was carried out by presensitization of the rat by using sheep serum and tripple antigen. Sensitization induces mast cell degranulation. The rats which were pretreated with standard drug, prednisolone (10 mg) and different extracts (petroleum ether, methanol and aqueous extract) of Withania somnifera at a dose of 250 mg, 500 mg and 750 mg were observed for the degranulation of mast cells, during the anaphylactic reactions. Treatment with methanolic extract of Withania somnifera at a dose of 500 mg shows beneficial effect on mast cell degranulation in sensitized rats. The activity was comparable with that of standard drug Prednisolone. Antianaphylactic activity of methanolic extract of Withania somnifera on the rat mesenteric mast cells may be possibly due to the membrane stabilizing...
Read More
Posted by admin on Mar 31, 2017 in |
The regulatory expectations are changing day by day on the cleaning validation in Pharmaceutical industries, considering the patient safety and drug efficacy. Manufacturing of an Intermediate and Active Ingredient Pharmaceuticals involves many chemical syntheses and same equipment is being using for manufacturing of different product in multi-production facility. Equipment cleaning plays a key role in controlling the contamination, to control the potential carryover of the product, cleaning methods shall be designed effectively to reduce the previous product residue. The current good manufacturing practice regulations state that cleaning is a critical issue to ensure the product quality. Improper cleaning results the carryover of the previous product residue and leads to failure of the product, so adequate cleaning procedures should be in place to clean the equipment to provide the documented evidence. The established cleaning procedures and cleaning methods shall be validated, life cycle approach is considered for the cleaning validation process. The article discussed about the outlines of the life cycle approach for the cleaning...
Read More
