Posted by admin on May 31, 2016 in |
This research work aimed at developing and optimizing fast dissolving tablets of Promethazine Thecolate by direct compression technique. In the investigation, a 32 full factorial design was used to investigate the joint influence of two formulation variables (amount of superdisintegrants): amount of sodium starch glycolate and crospovidone. The tablets were evaluated for its percent friability and their disintegration time. The results of multiple linear regression analysis revealed that for obtaining a rapidly disintegrating dosage form, tablets should be prepared using an optimum concentration of sodium starch glycolate and a crospovidone. A contour plot was also presented to graphically represent the effect of the independent variables on the disintegration time 30 s and percent friability 0.5 %. A checkpoint batch was also prepared to prove the validity of the evolved mathematical model. The optimized tablet should be prepared with an optimum amount of Sodium starch Glycolate (2.75 mg), and Crospovidone (2.72 mg) which disintegrated in the 30 seconds, with friability of 0.5% and of drug release within 5 min. The...
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Posted by admin on May 31, 2016 in |
A transdermal patch is a medicated adhesive patch that is placed on the skin to deliver a specific dose of medication through the skin and into the bloodstream. Often, this promotes healing to an injured area of the body. An advantage of a transdermal drug delivery route over other types of medication delivery such as oral, topical, intravenous, intramuscular, etc. is that the patch provides a controlled release of the medication into the patient, usually through either a porous membrane covering a reservoir of medication or through body heat melting thin layers of medication embedded in the adhesive. Transdermal drug delivery offers controlled release of the drug into the patient, it enables a steady blood level profile, resulting in reduced systemic side effects and, sometimes, improved efficacy over other dosage forms. The main objective of transdermal drug delivery system is to deliver drugs into systemic circulation through skin at predetermined rate with minimal inter and intrapatient...
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Posted by admin on May 31, 2016 in |
The objective of this research was to develop and validate a simple, sensitive and specific Liquid Chromatography – Tandem Mass Spectrometry (LC–MS/MS) quantification of Varenicline in human plasma using Varenicline -D4 as Internal Standard (IS). The analyte was separated on a Zorbax SB-C18, 4.6 x 75 mm, 3.5 μm, 80 Å column with an isocratic mobile phase of 5mM ammonium formate: acetonitrile (10:90 v/v) at a flow rate of 0.8 mL/min. The protonated ions were formed by a turbo ionspray in a positive mode was used to detect analyte and internal standard (IS). The analytes were monitored by electrospray ionization in positive ion multiple reaction monitoring (MRM) mode was used to detect the Varenicline at m/z 212.1/169.0. This method is validated over a linear concentration range of 50.0–10000.0 pg/mL with a correlation coefficient (r) of ≥ 0.9997. Both drug and internal standards were stable in plasma samples. This method demonstrated intra and inter-day precision within 1.2–4.5 and 3.5–7.4 and accuracy within 91.70-105.5% and...
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Posted by admin on May 31, 2016 in |
Caralluma lasiantha is a succulent plant belongs to Ascalpedaceae family. The objective of this study was to evaluate and to compare the anti-hyperglycemic effect of Caralluma lasiantha with Chromium Picolinate on hyperglycemia induced by Cafeteria-Diet in Wistar albino rats. Hyperglycemia was induced in experimental rats by feeding Cafeteria-Diet for a study period of 90 days. Caralluma lasiantha (10, 20, and 40 mg/kg b.w.) & Chromium Picolinate (10 mg/kg b.w.) were administered orally once every day throughout the study and serum glucose levels were determined in different experimental days. Treatment with Caralluma lasiantha significantly reduced the serum glucose level in dose dependant manner. Data reveal an appreciated beneficial effect of Caralluma lasiantha on hyperglycemic rats. Caralluma lasiantha possesses anti-hyperglycemic effect, which promisingly support the use of Caralluma lasiantha as a food supplement or an adjunct treatment for...
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Posted by admin on May 31, 2016 in |
The effects of zingerone, on antidiabetic and hypolipidemic potential in streptozotocin-induced diabetic rats were investigated in the present study. Diabetes mellitus was induced by a single intraperitoneal administration of streptozotocin (40 mg/kg bwt). Five days after STZ administration, diabetic rats received zingerone (10 mg/kg bwt) orally for 30 days. Metformin (Met) was used as reference drug. Zingerone treatment significantly reduced blood glucose level, Lipid profiles of serum, liver and kidney showed higher reduction in the levels of phospholipids, triglycerides and free fatty acids of zingerone treated diabetic rats than STZ-induced diabetic rats and Met-treated diabetic rats. In addition, zingerone treatment of STZ-rats was found to be effective in preserving the normal histological appearance of pancreatic islets, liver, and kidney, whereas the untreated diabetic rats exhibited pathological features. Thus, zingerone may have the potential in managing the effects of diabetic complications in human...
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