Posted by admin on May 31, 2016 in |
We planned to clarify the association between the Vitamin D supplementation and predisposition of metabolic syndrome including obesity, diabetes mellitus, hypertension and dyslipidemia in arthritic patient with pre diabetic condition and to assess prediabetes interfere in the disease progression. Retrospective observational study was conducted on 236 patients. Of these, Arthritis patients with no co-morbid condition and not supplemented with Vitamin D (47), Arthritis patients supplementing with Vitamin D (63), Arthritis patients with prediabetic condition (68), Arthritic prediabetic patients supplementing with Vitamin D (58) were recruited based on inclusion and exclusion criteria. All anthropometric parameters and clinical findings were recorded the predominance of women with RA was observed in this study and the body weight was increased substantially in entire study group irrespective of gender. A significant increase in metabolic parameters was observed in patients with arthritis who were off of Vitamin D supplementation (p<0.05). On the other hand no such significant increase was observed in vitamin D supplemented group (p>0.05. In the group of arthritic patients with prediabetes condition...
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Posted by admin on May 31, 2016 in |
Heterocyclic compounds are well known for their different biological activities like anti-inflammatory, antibacterial, antifungal, anticancer, insecticidal, pecticidal, antibiotic, etc. the versatile applications of oxygen, nitrogen and sulphur containing heterocyclic compounds have made this area of extensive research. The present study deals with the synthesis of some new 3-(2′-hydroxy-3′-nitro-5′-methylphenyl)-5-(aryl/heteryl) pyrazoles synthesis from 1-(2′-hydroxy-3′-nitro-5′-methylphenyl) – 3 – aryl/heteryl – 2-propen-ones i.e. chalcone by reaction with hydrazine hydrate in ethanol and synthesized compounds screening for antimicrobial...
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Posted by admin on May 31, 2016 in |
Diazonium salt of 2-(p-aminophenyl)-1,8-naphthyridine (I) was coupled with active methylene compounds to afford the hydrazono-1,8-napthyridinyl (III-V) and azo(VI) derivatives. Hydrazono ethyl acetoacetate (III) and ethyl cyanoacetate (IV) derivatives on treatment with hydrazine and substituted hydrazine’s were later reacted with hydroxylamine HCl in the presence of ethanol followed by cyclization to afford pyrazolinone (IIIa-e) & (IVa-e) and isoxazolinones (VII&IX). Hydrazono acetyl acetone (V) and azo dibenzoyl methane (VI) derivatives on treatment with hydrazine and substituted hydrazines, hydroxylamine HCl and with urea in the presence of ethanol followed by cylization resulted in the formation of pyrazoles (Va-e) & (VIa-e), isoxazole (IX&XI) and substituted pyrimidine-2-ones (X&XII). All the newly synthesized compounds were screened for their in-vitro antibacterial activity & antifungal activity by Agar cup-plate method and Serial dilution methods. In Agar cup plate method the Compounds IIId, IVd, VId showed Impressive antibacterial and antifungal activity. In Serial dilution method the compounds Vd & VId showed excellent antibacterial activity against B.Subtilis with an MIC of 7.8 µg/ml where as the compounds IVd, Vd...
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Posted by admin on May 31, 2016 in |
This review article investigates the prevalent existence of suicide along with its risk factors and contributing factors leading to the culmination of them all, in an attempt to look behind the black curtain. Suicide is the result of an unbalanced scale between the good and bad. Every year 300,000 teenagers attempt and succeed at suicide worldwide. A set of emotions and unpleasant thoughts develop in a person’s mind. The consequences of such ideas resulted in suicide becoming one of the leading causes of death in adolescents worldwide. Suicide is multi factorial in nature and is still under study, but this review explores mainly the etiological factors, including social, economical, psychological, biological and physical factors. Increasing the awareness campaign to educate people on suicide would return as a decreased suicidal number. It is our job as humans to help to decrease these heart shaking losses by suicide. This can be done through offering help and support, and seeking out professional help. This is an integral step toward the recovery of...
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Posted by admin on May 31, 2016 in |
Introduction: Non Steroidal Anti Inflammatory drugs are widely used drugs worldwide for various inflammatory conditions and acute as well as chronic pain conditions. In India large number of NSAIDs preparations are available in the market. Therefore choosing a NSAID becomes very difficult task for the prescribing physician. Objective: To evaluate the price variation of the different NSAIDs preparation available in the Indian market. Material And Methods: Cost of a particular drug in the same strength and dosage forms being manufactured by different companies was obtained from “Current Index of Medical Specialties” (CIMS) Jan-Apr, 2015 and “Indian Drug Review” (IDR) Issue 1,2015. Difference between the maximum and minimum cost of the same drug manufactured by different pharmaceutical companies was calculated and percentage cost variation was calculated. Spearman correlation analysis and regression coefficient was done to observe the correlation between no. of manufacturing companies and their percentage price variation with the help of IBM Statistical Package for Social Sciences (SPSS v.21). Result: NSAIDs combination were commonly found as Oral and Topical...
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