Posted by admin on Jun 1, 2013 in |
The genus Viburnum punctatum Linn. Under the family Caprifoliaceae (formerly) and Adoxaceae (currently) consists of about 200 species throughout the world. Many of these species have been recognized for their medicinal properties from very early times of this century. The aerial parts of Viburnum punctatum was collected from Nilgiri hills, Tamilnadu, India and was authenticated by Dr. A. B. Rema Shree, Dy. Project Director, Kottakkal Arya Vaidyasala, Kottakkal, Kerala, India. Phytochemical screening of the aerial parts of Viburnum punctatum was carried out. Result indicated that the aqueous extract of the plant material contain carbohydrate, glycosides, phenolic compounds, saponins and flavonoids. Antioxidant activity of the aqueous extract of the aerial parts of the plant material was carried out by DPPH scavenging assay and Reducing Power method and it found to have a good antioxidant...
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Posted by admin on Jun 1, 2013 in |
Background: Most recently fertility issues in HIV positive men and women are becoming increasingly important. Because of ART access and its good life effect, it is expected that the need and desire to get married, to have children and to have sexual partners for PLWHA would change with the regard to reproductive health. In Ethiopia HIV positive individuals may or may not have desire to have children. And the extent of this desire and how it varies by individual, health and demographic characteristics is not well known. Objective: the aim of the study was to assess desire for fertility and associated factors among PLWHA in selected ART clinics of Horro Guduru Wollega Zone, Oromia National Regional State, Ethiopia Methods: A cross-sectional, institutional-based study that employed quantitative and qualitative in-depth interviews was conducted. Three hundred twenty one study subjects were selected using systematic random sampling technique and the data was collected using interviewer administered structured questionnaire. Data entry and analysis were performed using EPI Info version 3.5.1 and SPSS version...
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Posted by admin on Jun 1, 2013 in |
Pain perception begins with the activation of primary sensory nociceptors. Over the past decade, flourishing research has revealed that members of the Transient Receptor Potential (TRP) ion channel family are fundamental molecules that detect noxious stimuli and transduce a diverse range of physical and chemical energy into action potentials in somatosensory nociceptors. Here we highlight the roles of TRP ankyrin 1 (TRPA1), TRP melastatin 8 (TRPM8), TRP vanilloid 3 (TRPV3) and TRP vanilloid 4 (TRPV4) in the activation of nociceptors by heat and cold environmental stimuli, mechanical force and by chemicals including exogenous plant and environmental compounds as well as endogenous inflammatory molecules. The contribution of these channels to pain and somatosensation is discussed at levels ranging from whole animal behavior to molecular modulation by intracellular signaling proteins. An emerging theme is that TRP channels are not simple ion channel transducers of one or two stimuli, but instead serve as promising drug targets for the management of pain. As a result, major efforts are put into the development of...
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Posted by admin on Jun 1, 2013 in |
The quest for eternal health has made mankind to intensively research the nature itself. Nature has a rich source of medicinal plants, the proper use of which is necessary to maintain health. According to WHO, almost 80% of the population of developing countries has utmost faith in traditional medicines, of which plants are the important source. WHO recommends macroscopic and microscopic studies of the herb should be the first step in authentication, which is necessary to ensure the quality of any medicinal product. Cyperus rotundus (L.), a medicinal plant belonging to the family of the Cyperaceae, grows all over India. In the present study macroscopic and microscopic characterization of the rhizomes of Mustawas done to develop an atlas of diagnostic characters by the standard methodology of macro-microscopic characterization of herbal raw drugs. Macroscopical and organoleptic characters as well as the microscopic features of Musta rhizomes were documented. A self-explanatory atlas of photomicrographs was prepared to aid rapid identification of raw drug called Musta. The atlas will serve as standard...
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Posted by admin on Jun 1, 2013 in |
The present study was undertaken to investigate the hepatotoxic potential of rosiglitazone- an oral hypoglycemic thiazolidenedione class of drug. The hepatotoxic potential of rosiglitazone was assessed in-vitro on isolated rat hepatocytes before subjecting to in-vivo studies. The in-vitro activity was measured by trypan blue exclusion assay and determination of liver marker enzymes. The hepatotoxic potential of rosiglitazone was measured at 100 to 500 µg/ml concentration and maximum hepatotoxicity was produced at highest concentration tested. In-vivo hepatotoxic potential of rosiglitazone was assessed on hyperglycemic rats and protective effect of silymarin a known hepatoprotective agent was also tested. When rosiglitazone was administered at the dose of 2 mg/kg body weight for 21 successive days on rats, has produced marked hepatotoxicity when compared to normal animals. The hepatotoxic potential was evaluated by determination of serum biochemical markers and liver anti-oxidant enzyme studies. Hypoglycemic effect of rosiglitazone in presence of silymarin was also assessed in alloxan induced hyperglycemic rats to rule out any drug interaction. The rosiglitazone has produced significant elevation of serum...
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