Posted by admin on Jun 1, 2013 in |
Background: Glioblastoma Multiforme is the commonest of all astrocytomas. It accounts for 12-15% of all intracranial neoplasm and 50-60% of all astrocytic tumors. Most common site of occurrence is cerebrum and age incidence is highest in fifth and sixth decade. Gliosarcoma constitutes 2% of all brain tumors, 5% of all astrocytomas and 8% of anaplastic astrocytomas. The cell of origin of sarcomatous component has not been fully established. Aim: The purpose of our study is to evaluate histopathological features of GBM in detail, in relation to the age, sex and site of occurrence, in Ganga Ram Hospital, during a period of 10 years and also to find out the relative frequency of Gliosarcoma among glial tumors. Particular emphasis is on to evaluate the nature of glial as well as mesenchymal component and their relationship in Gliosarcoma with the help of immunohistochemistry. Materials: Total of 115 cases of Glioblastoma multiforme were studied histopathologically in detail, with some clinical corelation in Sir Ganga Ram hospital. 13 cases of Gliosarcomas, diagnosed morphologically...
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Posted by admin on Jun 1, 2013 in |
Tuberculosis (TB) is an ancient disease that has caused inestimable suffering and claimed millions of lives over the centuries. Resistant strains of Mycobacterium tuberculosis have slowly emerged especially in developing countries due to the lack of health care organisation in order to provide the long and costly treatment adapted to patients. In fact, 90% of all TB cases occur in the developing world. People with HIV/AIDS are especially susceptible to tuberculosis due to lack of immune system.Tuberculosis has been treated with combination therapy for over fifty years. Drugs are not used singly (except in latent TB or chemoprophylaxis), and regimens that use only single drug result in the rapid development of resistance and treatment...
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Posted by admin on Jun 1, 2013 in |
There has been a vast growth in the field of herbal medicine and these drugs popularly are increasing both in developing and developed countries because of their natural origin, more therapeutic effect and less side effects. Since ancient cultures, tribal people methodically collected information on herbs and developed well-defined herbal drugs for the treatment of many diseases. In cancer, cells divide and grow uncontrollably, forming malignant tumors, and invade nearby parts of the body. The cancer may also spread to more distant parts of the body through the lymphatic system or bloodstream. Cancer grows out of normal cells in the body. Normal cells multiply when the body needs them, and die when the body doesn’t need them. Mostly, cancer patients are gaining benefit from treatment with herbal medicine. This review article covers the possible mechanism of action of some of the herbal medicine and ayurvedic herbs used as anticancer...
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Posted by admin on Jun 1, 2013 in |
The usefulness of computational methods in drug design process is no longer a point of debate. The contributions from this evolving field have become apparent to both pharmaceutical scientists and academic biomedical researchers. As all the computational drug design are based on statistical and mathematical calculations there is strong evidences present for each and every step, thus research by chance is no longer exist. From statistical analysis of large data set, up to quantitative prediction, one can get simply by seating in front of graphical terminal and using this technique. Success stories from these endeavors are appearing in the literature at an impressive rate. Since the search for new antiviral drugs with reduced toxicity and lower side-effect is continues. Antiviral of class HIV reverse transcriptase are found to have wide range of activities but still this drugs are not very effective in curing HIV infected persons. So this drugs study is carried out and will show more biological and therapeutic activity by performing work of homology modeling and docking...
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Posted by admin on Jun 1, 2013 in |
Excitotoxicity refers to the pathological process by which nerve cells are damaged & killed by glutamate or related excitatory amino acid under conditions such as after intense exposure. This occurs when receptor for the excitatory neurotransmitter such as N-methyl-D-aspartate (NMDA) or AMPA are over activated. Such excitotoxic neuronal death may take part in the pathogenesis of brain or spinal cord injury associated with several human disease states. Various mechanisms involving excitotoxicity have been proposed to explain the neuronal cell death characteristic of neurodegenerative diseases, including elevation of intracellular calcium, accumulation of oxidizing free radicals, impairment of mitochondrial function and activation of apoptotic...
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