Posted by admin on May 31, 2020 in |
Benzimidazoles are well known biologically active N-containing heterocycles, widely used as drugs such as antifungal, antibacterial, antiparasitic, and antihelmintic. In addition, N1 and C2-substituted benzimidazoles and their derivatives have been found to be potent biologically active compounds as well. Further, N1-substituted benzimidazoles have exhibited anti-microbial, antihelmintic activities and also antiviral activity against human cytomegalovirus and herpes simplex virus type-1. Specifically, N1-substituted benzimidazole like 5,6-dichloro-1-β-D-ribofuranosylbenzimidazole is known for inhibition of transcription elongation by RNA polymerase II. Another N1-substituted benzimidazole derivative called enviroxime [2-amino-1- (isopropyl-sulphonyl)-6-benzimidazole phenyl ketone oxime] was reported to be a potent inhibitor of rhinovirus replication in human embryonic nasal organ cultures. The biological activities of these compounds depend upon the substitution on the benzimidazole at the N-1 or C-2 position. Since the benzimidazole heterocyclic ring system mimics the purine bases like adenine and guanine of nucleic acids, the N1-substituted benzimidazole may incorporate into viral nucleic acid by enzymatic process and subsequently can alter the structure and/ or function of viral...
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Posted by admin on May 31, 2020 in |
The objectives were to observe the drug pattern of epileptic patients with their seizure type, to analyze the type of therapy received by the patients, to observe if epileptic patients are receiving an appropriate dose, to identify the side effects in epileptic patients associated with drug treatment and to observe the cost of conventional and newer antiepileptic drugs (AED’s). This was a cross-sectional observational study conducted in the Neurology department. A total of 150 patients were selected based on the inclusion and exclusion criteria. Demographic details and clinically relevant details such as therapy, dose of the drug, side effects experienced pertaining to the objectives of the study were collected using the self-prepared proforma. Symptomatic localization (64%) was the most commonly observed epilepsy syndrome. The commonly observed type of therapy among the patients was dual therapy. AED dose prescribed for most of the adult population was at a sub-optimal level, as explained by the daily defined dose/ prescribed daily dose (DDD/PDD) ratio (<1). Carbamazepine and oxcarbazepine were prescribed at a...
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Posted by admin on May 31, 2020 in |
Schiff bases from chitosan and 5-nitro salicylaldehyde-aniline complexes represented the important structural subject in excess of biologically active molecules, including synthetic. The introduction of 5-nitro salicylaldehyde at C-2 nitrogen position and aniline at C-6 oxygen position of chitosan. The structure-activity relationship (SAR) of the double Schiff based chitosan, synthesized from the condensation reaction of equimolar amounts of 5-nitrosalicyl-aldehyde, chitosan, and aniline in DMSO. The chitin and the phenyl rings deviate from co-planarity with an inter and intra-molecular bond (–C2-N=CH–), (–C6–C=N–). The title compound C69H118N11O43 is not a planner, with a dihedral angle among the planes of the three aryl rings. The structure is a heterocyclic derivative constituting a stimulating class of compounds with synthetic flexibility and productive biological activities. The synthesized compound structurally categorized by FT-IR, 1H-NMR, GC-Mass spectra, and TG/DTA studies. The 1H-NMR spectroscopy used to determine the degree of acetylation in chitosan. The synthesized compound primarily parted for their in-vitro growth constraining activity against a different strain of bacterial and fungal. The in-vitro antioxidant activity of the...
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Posted by admin on May 31, 2020 in |
Laccase belongs to polyphenol oxidases, which is a very wide family of copper-containing atoms in the center, which serves as the catalytic site. It is biochemically a glycoprotein with molecular mass being between 50kda to 130kda and 30% carbohydrate content, in addition to this it has three types of copper atoms. It is one of the most important enzymes due to its role in the food industry. It acts as a biosensor where it can detect morphine, codeine, catecholamine, and many other enzymes. In insects, it performs the function of cuticle sclerotization. Moreover, laccase is safe for human consumption. The most important factor which has prevented laccase from being insanely famous is the cost that is associated with using a very large quantity of laccase. Laccases can be extracted from almost all kinds of white-rot fungi as well as from various other fungi species such as Pycnoporus cinnabarinus, Gloeophyllum trabeum but not in any brown-rot species except Coniophora puteana as was recently discovered. Aspergillus niger, Aspergillus oryzae and Trichoderma...
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Posted by admin on May 31, 2020 in |
Moringa is one of the medicinally important genera and Moringa concanensis Nimmo is a threatened species of it. Clonal micropropagation has been used to produce true to type multiple copies and help to conserve a number of plants. A comprehensive micro-propagation protocol has been developed in the present study. It was found that Murashige and Skoog (1962) (MS) basal elements enriched with 0.05 mg/L of 1-naphthalene acetic acid (NAA) in combination with 0.3 mg/L of 6-benzyl amino purine (BAP) induced 93.3% shooting and maximum (5.5 ± 1.63) number of micro-shoots. Shoot elongation and multiplication were recorded to enhance by making use of 1.0 mg/L of Gibberellic acid (GA3). Maximum rooting (83.3%) was observed on half-strength MS basal media supplemented with 0.5 mg/L of Indole 3-Butyric Acid (IBA) in combination with 0.5 mg/L NAA. Even though the success of this protocol is varied according to genotype, it still has high applicability for the conservation of germplasm of...
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