In this article, an attempt has been made to explore a positive correlation between obesity and type 2 diabetes mellitus. The possible role of several important agents in causing both has been discussed in detail. From the discussion, it seems that obesity is definitely and intimately linked to type 2...
Read MoreNeonatal sepsis is associated with increased mortality and morbidity including neurodevelopmental impairment and prolongation of hospital stay. Clinical features of sepsis are non-specific in neonates and a high index of suspicion is required for timely diagnosis. Antibiotics are a very important group of drugs for the sick neonate and have undoubtedly played a role in their improved survival. But they come with a set of risks like other drugs used in critical care which must be carefully considered and weighed against the benefits in any decision to commence antibiotics. Prophylactic antibiotics are not indicated in almost all situations in neonatology. There is high level of evidence to show that they are not useful for the prevention of infection following umbilical vessel or central venous catheterization. Traditionally, the selection of antibiotics for empirical therapy is based on the local policy, and the duration of therapy is decided by the treating physician based on clinical symptoms and blood culture results. In this paper, we discuss briefly about the causative organisms of...
Read MoreChalcones are 1, 3-diphenyl-2-propene-1-one, consist of two aromatic rings linked by a three carbon α, β-unsaturated carbonyl system. The chemistry of chalcones has generated intensive scientific studies throughout the world. Especially interest has been focused on the synthesis and biodynamic activities of chalcones. These are considered to be precursors of flavonoids and isoflavonoids. The aim of this review is to summarize chalcones and their diverse pharmacological activities like anticancer, antimicrobial, analgesic and antiviral activities...
Read MoreBackground: Type 2 Diabetes is a metabolic disorder, characterized by chronic hyperglycemia. It results from insulin resistance, a condition in which the body cells fail to use insulin properly. In Ayurveda Sesamum alatum L. (Pedaliaceae) has been used for the treatment of Diabetes. In this study, the antidiabetic activity of the Methanolic leaf extract of S. alatum was investigated, and the renal protective activity of the extract was also evaluated in diabetic rats. Materials & Methods: Antidiabetic activity of the Methanolic Leaf Extract of Sesamum alatum (MESA) was evaluated in the Streptozotocin (65mg/kg) induced Male albino rats. Blood was collected from the Retro orbital plexus of rats’ before and after the administration of MESA. Activity of 300 and 500 mg/kg doses of MESA were evaluated for a period of 30days. Urine samples were collected and analyzed for Albumin, BUN, Creatinine and Lipid parameters. In addition, Kidney MDA levels, Antioxidant enzymes (SOD, CAT) and Non-Enzymatic (GSH) levels were measured. Results: Dose-dependent reduction in blood glucose levels were observed in treated...
Read MoreA reverse phase high performance liquid chromatography (RP-HPLC) method for the simultaneous estimation of amlodipine and lisinopril in marketed formulation is developed. The determination was carried out on a Phenomenex C18 (250 x 4.6 mm, 5 µm) column using a mobile phase of 0.02 M phosphate buffer solution: methanol (75:25v/v, pH 7.0). The flow rate was 1.0ml/min with detection at 212 nm. The retention time for amlodipine was 4.11 min and for lisiopril 7.29 min. Amlodipine and Lisinopril showed a linear response in the concentration range of 10-110 µg/ml. The correlation co-efficient (‘ r ‘ value) for amlodipine and lisinopril was 0.9991 and 0.9992, respectively. The results of analysis have been validated statistically and by recovery studies. The percentage recoveries obtained for amlodipine and lisinopril ranges from 100.04 to...
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