Posted by admin on Jun 30, 2024 in |
Aim: This study aims to explore the potential of transdermal drug administration as a viable alternative to conventional medication delivery systems. Specifically, the focus is on the development and evaluation of transdermal patches containing Lamivudine and Stavudine for the treatment of AIDS. The overarching objectives include extending drug release duration, reducing administration frequency, and enhancing patient compliance. Material & Methods: The formulations under investigation are meticulously designed using a combination of HPMCK15M, PVPK30, and EC in varying ratios. The patches are subjected to a thorough assessment, encompassing critical parameters such as film thickness, tensile strength, and drug content homogeneity. The incorporation of Tween 80 and dimethyl sulfoxide as plasticizer and penetration enhancer is a key methodological consideration for optimizing the transdermal patches. Additionally, the study explores the impact of natural permeation enhancers, such as oleic acid, eucalyptus oil, and clove oil, on drug permeation and release kinetics. Results: The outcomes of the study reveal promising findings, with the transdermal patches exhibiting favorable characteristics, including optimal film thickness, tensile strength,...
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Posted by admin on Jun 30, 2024 in |
Numerous genetic and epigenetic differences contribute to the complexity and multifaceted nature of the disease known as cancer. Artificial intelligence is opening up a lot of possibilities in the fight against cancer. AI-guided clinical care has the potential to significantly reduce health problems, particularly in low-resource countries. Numerous tools and applications of AI are being offered in the field of oncology. The most significant illness at the moment is cancer. AI played a significant influence at a time when treating cancer was extremely tough. AI has the potential to significantly advance cancer surveillance, speed drug discovery, and help characterize cancers’ genomes. Today, AI is utilized to treat tumors of the cornea, lungs, cervix, and other types. This article discusses all types of tumors, their effects, AI-assisted diagnosis, and treatment. In addition to highlighting the different ways artificial intelligence is exploding in oncology, this article also discusses the challenges that humans must face in overcoming AI’s...
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Posted by admin on Jun 30, 2024 in |
Proniosomes are provesicular dried or anhydrous formulations that are composed using non-ionic surfactants and solvents. The non-ionic surfactant’s hydrophilic portion orients outward to form a bilayer, while the hydrophobic portion moves inward. Medicines with hydrophilic properties are contained in vesicles, while hydrophobic drugs get embedded in proniosome bilayers. Proniosomes are physically stable while storage and handling when compared to liposomes and niosomes. They can be used to impart targeted drug action, enhance retention time, increase penetration of drug at target tissue, sustain/ control drug release and minimize side effects. These proniosomes can be rehydrated with hot aqueous solution and constant stirring and transformed to niosomes immediately when needed. Generally, proniosomes are either converted to niosomes or proniosomal gel for transdermal drug delivery to use of the benefits associated with proniosomes. This review article focuses on structure, mechanism of drug transport, composition, preparation, characterization methods of proniosomes and the research carried out in past in field of provesicular drug delivery...
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Posted by admin on Jun 30, 2024 in |
The present study aimed to evaluate the effect of hydroalcoholic extract of Sida spinosa L. (HYSS) in antigen induced rheumatoid arthritis in mice by intra articular administration of Bovine serum. Rheumatoid arthritis was induced by the mixture of antigen (Bovine serum albumin) and adjuvant (Imject alum) in 1:1 ratio on 1st, 7th and 21st day as an induction period. The mixture of antigen and adjuvant caused the joint destruction, chronic inflammation of synovium, pannus formation, erosion of bones and cartilage in mice. The HYSS administered at three different concentrations 100, 200 and 400 mg/kg,p.o. as test and Indomethacin (2 mg/kg, p.o) as reference standard for next 20 days as a treatment period in arthritis induced mice. The study was conducted for total 41 consecutive days as initial 21 days of induction and next 20 days as treatment period. Progression of arthritis in different group of animals was evaluated by biochemical parameters, histological changes, antioxidant activity and radiographic analysis in overall joint structure. HYSS at 200 and 400 mg/kg significantly...
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Posted by admin on Jun 30, 2024 in |
The pharmaceutical industry is undergoing a significant transformation due to technological advancements, scientific breakthroughs and evolving healthcare needs, paving the way for more effective treatments and improved patient outcomes. AI and ML are revolutionizing drug discovery and development by analysing vast datasets, predicting drug interactions and accelerating the identification of potential therapeutic compounds, reducing costs and improving clinical trial design and data analysis. Improvement of public health through revolutionizing the pharmaceutical industry is envisioned as multidirectional, encompassing utilization of AI and Data Analytics. The industry has strengthened in terms of drug discovery, personalized medication development and production enhancement through streamlined procedure adoption. Drug safety checks and data driven synthesis through streamlined processes offer substantial ground for future progressions in the industry. The present study explores various dynamics of the pharmaceutical industry from the perspective of developmental evolution both, on short term periods and over the period of decades. Incorporation of technology in aspects such as medication personalization, research and development as well as production capacity and precision has been...
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