Posted by admin on Jun 30, 2024 in |
Background: Natural bioactive compounds of plant origin have attracted comprehensive attention due to their multiple biological effects, including antioxidant and immunomodulatory activities. However, scientific underpinnings of these health benefits are inadequate. Objective: Present investigation was undertaken to evaluate the bioavailability, antioxidant, and Immunomodulatory activity of the herbal formulation Lemon Peel extract (Storg-FA), which contains Lemon Peel extract standardized for 5% Folic Acid, along with co-nutrients including various water-soluble natural folates. Methods: The invitro antioxidant activity of Storg-FA was evaluated using the DPPH radical scavenging assay whereas cyclophosphamide induced immunosuppressed rat model was established to investigate the immunomodulatory activity of Storg-FA in Sprague-Dawley (SD) rats. Haemagglutination test was used to assess their effects on humoral response. After 14 and 21st days of drug administration, the extent of protection against immunosuppression caused by Cyclophosphamide was assessed by estimating hematological parameters. The invivo bioavailability study of Storg FA was conducted using LC-MS/MS analysis. Results: Storg-FA showed pronounced invitro antioxidant activity against DPPH radical. IC50 of Storg FA was found to be 109.35µg/ml,...
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Posted by admin on Jun 30, 2024 in |
Background: Venous thromboembolism is the most common preventable cause of in-hospital mortality. Despite this, thromboprophylaxis practices vary related to order sets and special populations. Aim: To describe thromboprophylaxis strategies and awareness of institutional policies. Methods: Electronic survey of pharmacists having general medicine institutional practices within Alberta, Saskatchewan and Manitoba in 2017. Results: Amongst 88 (24.2%) respondents, the majority (60.2%) had practiced >5 years, and were working full time (81.8%) as staff pharmacists (94.3%). The majority (80.7%) used institutional order sets. In patients with normal weight and renal function, agents used were: dalteparin (36.4%), enoxaparin (31.1%), unfractionated heparin (UFH) (15.4%) and tinzaparin (11.3%), while for those with CrCl<30mL/min or hemodialysis, UFH (55.7% and 65.2%) and enoxaparin (23.5% and 26.3%) were used. Escalating doses for obesity were used by 86.7%, with upper weight extremes, defined in kilograms by 50.0% (median 100kg [range 100-150]), and BMI by 29.5% (median 40 [30-40]). Reduced doses were used for emaciation by 72.3%, with lower weight extremes defined in kilograms by 63.6% (median 40kg [30-50]). Prophylaxis...
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Posted by admin on Jun 30, 2024 in |
This study aims to enhance the therapeutic effectiveness of reserpine, an essential anti-hypertensive agent, by addressing its poor solubility and dissolution properties. Employing a Quality by Design (QbD) methodology, the research systematically optimized the formulation using solid dispersion technology and fast-dissolving films. Characterization of reserpine included its physical properties, such as melting point and partition coefficient, along with the establishment of a validated UV method for accurate quantification. The optimized solid dispersion (DRPSD14) achieved a theoretical solubility of 14.94% and dissolution of 96.88% at 20 minutes. Subsequently, a fast-dissolving film was developed from the optimized solid dispersion. Among twelve formulations, DRPSD14FDF11 exhibited promising characteristics, with 98.977±0.253% reserpine content. In-vitro dissolution studies demonstrated rapid dissolution for all formulations, with DRPSD14FDF11 displaying the highest dissolution rate. Release kinetics modeling and Fourier-transform infrared spectroscopy (FTIR) confirmed uniform drug distribution in the film, which also exhibited stability under various storage conditions. Guided by QbD principles, this comprehensive approach successfully optimized reserpine’s pharmaceutical properties, offering a promising formulation for hypertension treatment. The study provides...
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Posted by admin on Jun 30, 2024 in |
In today’s dynamic industrial landscape, the transformative potential of pellets and pelletizing technology stands as a beacon of innovation. Pellets, compacted forms of raw materials, have emerged as versatile solutions across diverse sectors, from agriculture to pharmaceuticals, offering enhanced efficiency and sustainability. The advent of advanced pelletizing technologies has further elevated their impact, enabling precise control over size, shape, and composition. This abstract explores the profound implications of pellets and pelletizing technology, delving into their role in optimizing processes, minimizing waste, and unlocking new avenues for resource utilization. Through a blend of engineering ingenuity and ecological consciousness, this paradigm shift underscores a promising future where pellets redefine the boundaries of production efficiency and environmental...
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Posted by admin on Jun 30, 2024 in |
More attention on natural antimicrobials and antioxidants have increased. The medicinal plants production has high in Mediterranean region. WHO says many drugs can be obtained by using medicinal plants. Medicinal plants have many compounds of bioactive that gives more metabolic action on the human body. The congestive heart failure treatment and cardiac arrhythmia treatment can be treated by glycosides drugs. The glycosides have potent in curing many problems like cardiac insufficiency, coughs and circulatory problems. Glycosides acts as good sedatives and good antispasmodic properties. Saponins were found in Ligustrum sinense shows tendency for treating infections of fungal and yeast. The Ethyl acetate leaf mixed extract showed more effective of in phytochemical screening and against the tested microorganisms, Compare chloroform leaf...
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