Posted by admin on Jun 30, 2024 in |
A simple, precise yet novel UV spectrophotometric method has been developed for the simultaneous estimation of luliconazole and eugenol. Two methods, namely the simultaneous equation method and the absorbance ratio method were tried for simultaneous analysis. Since the simultaneous equation method gave the best recovery; the simultaneous method was developed for the estimation of both drugs. The wavelength of interest is the wavelength maxima of both drugs; λmax of luliconazole 296 nm and λmax of eugenol 282 nm. The correlation coefficient value (r2) was found to be 0.99 for linearity studies both in methanol and phosphate buffer. Validation studies of the developed method were conducted as per ICH guidelines. The method was precise since the percent relative standard deviation was less than 2 and accurate since the percent recovery was between 99.42% and 105.16%. The developed method can be further used for simultaneous analysis of the drugs in bulk and formulation by UV spectroscopy. The development of a suitable analytical method for quantitative estimation is essential for assay and...
Read More
Posted by admin on Jun 30, 2024 in |
Diabetic Peripheral Neuropathy (DPN) is a prevalent and debilitating complication of diabetes mellitus, impacting the global well-being of millions. This review provides a concise overview of the key aspects related to DPN, including its pathophysiology, diagnostic approaches, and current pharmacotherapeutic interventions. The pathophysiology involves intricate mechanisms driven by hyperglycemia-induced oxidative stress, inflammation, and metabolic dysfunction, resulting in peripheral nerve damage. Diagnosis relies on a combination of clinical and electrophysiological assessments. Pharmacotherapy, a pivotal component in DPN management, encompasses analgesics, anticonvulsants, and neurotrophic agents, aiming to alleviate symptoms and impede disease progression. The abstract underscores the need for a multidisciplinary approach and ongoing research to enhance the understanding and treatment of DPN, ultimately improving the quality of life for individuals affected by this...
Read More
Posted by admin on Jun 30, 2024 in |
Fungal infections represent a significant global challenge within the realm of dermatology. The prevalence of fungal infections is notably high, affecting approximately 40 million individuals in developing and underdeveloped countries. Considering this, our study proposes a novel approach: transdermal drug delivery utilizing herbal formulations to enhance efficacy & minimize side effects in the treatment of fungal infections. Seven Ayurveda plants extracts were selected & formulated in a 1:1 ratio. These herbal formulations were incorporated into dermal patches composed of HPMC& PEG. Subsequently, the herbal transdermal patch was subjected to characterization like UV spectrometry, folding endurance, thickness measurement, & surface pH determination. The antifungal property of these patches was evaluated against Candida albicans by determining MIC and Agar Well method. The prepared patches exhibited distinctive UV-visible spectra within the 200-800 nm range for the HPMC-based, displayed a thickness of 0.063 ± 0.01, a weight of 206 ± 5.1 mg, and a surface pH of 5.7. The transdermal drug delivery system demonstrated potent fungal inhibition at a concentration of 2.5 mg/ml,...
Read More
Posted by admin on Jun 30, 2024 in |
Celiac disease is a multisystem immune based disorder that is triggered by the ingestion of gluten in genetically susceptible individuals. Our study was limited to a survey of the prevalence of Celiac disease in adult in two Syrian governorates (Homs and Tartous), Statistics were collected from hospitals and clinics of gastroenterologists and nutritionists, during the period of 2014-2022. 4000 cases of Celiac disease were recorded in these two Syrian governorates with a population of about 5 million people with ages ranging from 20-33, that is 0.08% in these cases. The presence of HLA class II antigens was observed in all people with Celiac disease as HLA DQ2 was found in 82% of celiac disease patients, and HLA DQ8 was found in the rest. It is very important that follow-up showed that the results of antibody tests (Transglutaminase IgA) in patients adhering to the gluten-free diet decreased from 200 to 100 “during a year of treatment” and to 20 “during two years of treatment” in all patients. The decrease in...
Read More
Posted by admin on Jun 30, 2024 in |
The increasing demand for natural polymers has fuelled substantial investment in research and development within the pharmaceutical and biotech sectors. Natural polymers, lauded for their biocompatibility, biodegradability, and safety, offer versatile advantages and among these, polysaccharides and proteins stand out. One class of natural polymers, gums, obtained primarily from plants, is gaining prominence in pharmaceuticals, biotechnology, and food industries. Notable examples include Xanthan gum, Guar gum, Locust bean gum (LBG), and Tara gum, all sharing the galactomannan compound at their core. LBG exhibits a range of physical and chemical properties that make it a valuable candidate for drug delivery systems. This natural biopolymer, with its unique characteristics, presents a compelling case for incorporation into oral drug delivery systems. The chemical composition of LBG makes it well-suited for interaction with other natural polymers. This interaction can lead to the development of novel drug delivery systems with controlled-release, improved solubility, and enhanced bioavailability. LBG’s compatibility with various natural polymers offers a wide array of possibilities for formulation enhancement. Pharmaceutical applications of...
Read More
