Posted by admin on Jun 30, 2023 in |
Rheumatoid Arthritis (RA) is an autoimmune inflammatory illness characterized by persistent synovial inflammation. It’s the most common form of arthritis that causes inflammatory changes in the tissue of joints, destroys cartilage and bones, and affects the quality of life. This diverse disease has a wide range of disease progression and treatment responses. Because the precise origin of rheumatoid arthritis is still unknown, no medicine can ensure a full recovery. Biomarkers guide the clinical and pharmacological management of rheumatoid arthritis at all phases. This is because they can help in the monitoring of disease activity and progression, the prediction of illness beginning in at-risk patients, and the provision of predictive data. American College of Rheumatology (ACR) emphasized on initial investigation of clinical findings based on the physical data for the diagnosis of RA. Although Rheumatoid factor and anti-citrullinated protein antibodies are the two biomarkers that can be used to determine who is at risk for the condition and who has pre-clinical rheumatoid arthritis before symptoms develop, there are involvements of...
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Posted by admin on Jun 30, 2023 in |
The importance of flaxseeds in the food sector has been highly appreciated due to the presence of phytochemicals and antioxidants. The aim of the present study was to focus on the effect of different solvents used for the extraction of bioactive phytochemicals from raw, fermented, and germinated deoiled flaxseed flours and also evaluated their antioxidant activities. The phenolic content and flavonoid content of 80% ethanolic extract of germinated deoiled flaxseed flour were greater than the raw and fermented deoiled flaxseed flour. This study also focused on the identification of polyphenol compounds present in flaxseed flour extract which varies due to fermentation and germination processes and showed that germinated deoiled flaxseed flour extracts contained the highest number of polyphenol compounds. The germinated flaxseed flour extract was found to be exhibited at the highest zone of inhibition against S. aureus, B. substilis and E. coli. In our results, it was found that germinated deoiled flaxseed flour extract has higher antiarthritic activities. The study established that both the fermentation and germination processes...
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Posted by admin on Jun 30, 2023 in |
Kota district is situated in the south-eastern region of Rajasthan and is well known for its floral biodiversity. The present study has been done in the Nanta forest area located in the Sakatpura forest range in forest division Kota. This area is still unexplored in terms of ethnomedicinal plant diversity, which provides a new area for research in human wellbeing and biodiversity conservation. The Present study reveals ethnomedicinal diversity, their identification, and medicinal uses based on the knowledge gathered from rural folk, natives, and local traditional medicine practitioners (vaids). The data collected was validated with secondary sources. Due to high anthropogenic activities, there is a risk of losing the present diversity of ethnomedicinal plants in the study area. It is requisite to preserve the diversity of this region. Based on participatory observation and talk with local inhabitants, 60 species belonging to 26 families were identified, which were used as ethnomedicinal resources by local inhabitants. Stomach-related diseases, skin diseases, rheumatism, and asthma are the most diseases for which therapeutic values...
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Posted by admin on Jun 30, 2023 in |
The development of mucoadhesive buccal formulations has recently gained a great deal of attention. Despite several proposed solutions, drug permeability and regulated drug release via this mode of delivery remain concerns for successful therapy. Clinical uses for recent advances in nanotechnology have been examined. In addition to ensuring effective distribution, the use of nanoparticles in dosage forms for buccal administration also helps to minimize any negative effects on biological systems. To load and distribute drug-containing nanoparticles to the buccal mucosa for topical and systemic applications, several strategies have been proposed. In order to improve medication delivery or targeting, this study outlines contemporary cutting-edge approaches for using nanoparticles in dosage forms. Of give a general overview of current approaches to implementing controlled drug delivery, these technologies are categorized and discussed. All of these noteworthy results will promote novel nanoparticle-delivered dose formulations for buccal distribution in clinical settings. Overall, the buccal mucosa provides a lot of advantages for controlled pharmaceutical delivery over an extended period of...
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Posted by admin on Jun 30, 2023 in |
A series of flavones derivatives 11(a-j) have been synthesized and evaluated for their in-vitro antibacterial and antifungal activities. The antibacterial screening data showed that compounds with 4-methoxyphenyl (11c), 4-fluorophenyl (11d), and 2, 5-fluorophenyl (11h) substituent’s on tetrazole ring, showed the maximum activity against the organisms used. The antifungal screening revealed that a compound with 4-nitropheny (11g) on tetrazole ring exhibited the highest activity against A. niger and a compound with 4-methoxyphenyl (11c) group exhibited good activity against C....
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