Posted by admin on Jun 30, 2018 in |
Propranolol is beta-blocker and it is widely used in the management of hypertension. Propranolol is used to treat tremors angina, hypertension, heart rhythm disorder and other heart or circulatory conditions. The mucoadhesive buccal tablets of propranolol were papered by wet granulation method using natural polymer like Vigna mungo powder. The compatibility studies of drug and excipient were performed by FT- IR spectroscopy and DSC. After examining the flow properties of the powder blends the results were found to be within prescribed limits and indicated good flowing property, hence it was subjected to compression. The tablets were evaluated for post-compression parameters like weight variation, hardness, thickness, friability, drug content uniformity, surface pH, in-vitro studies like swelling, mucoadhesive strength, residence time and drug release. Formulation (F6) containing Vigna mungo showed good muco-adhesive strength (21.75g) and maximum drug release of 89.31% in 12 h and residence time (6.9 h). The drug content shown 92.19%, surface pH was found to be 6.9. All the evaluation parameters given the positive result and comply with...
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Posted by admin on Jun 30, 2018 in |
A diet rich in marine fishes and general seafood has long been recommended by several medical authorities as a long-term nutritional intervention to preserve overall health and wellbeing. An association between consumption of fish and seafood and beneficial effects on a variety of health outcomes has been reported in epidemiologic studies and clinical trials. These effects are mainly attributed to the omega-3 long-chain polyunsaturated fatty acids (n-3 PUFAs) abundant in fish and seafood, and in particular to eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Reports on health benefits have led to increased demand for products containing marine n-3 PUFAs. Since fish is a restricted resource, there is growing interest in exploiting alternative sources of marine n-3 PUFAs. Antarctic krill (Euphausia superba) is a rich source of n-3 PUFAs. Most of the health benefits provided by frequent seafood consumption come from adequate uptake of omega-3 and omega-6 polyunsaturated fatty acids, n-3/n-6 PUFAs, and antioxidants. Optimal n-3/n-6 PUFAs ratios allow efficient inflammatory responses that prevent the initiation and progression of many...
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Posted by admin on Jun 30, 2018 in |
Functionality of Ion Exchange Resin (IER) mainly depends on solubility and degree of ionization and molecular weight of drug. For this reason the application of IER is limited to only strong acidic and basic drugs or drug existing as salt; not for weak acidic and weak basic drugs due to their low ionization properties. If we increase the ionization of weak acid and bases, then application of IER will not only be limited to salts or strong acid or strong bases but also for weak acid and bases and hence almost all drugs will be complexed with IER and total exploitation of application of IER can be achieved. Solubility increasing approach such as cosolvent and 2 Hydroxypropyl betacyclodextrin and ionization increasing approach such as keeping the pH above drug ionization constant (pKa) were followed to evaluate their effect on loading of a weekly acidic drug, Repaglinide (taken as model drug) and found that keeping the pH of the complexation medium more than drug pKa had maximum percentage drug loading...
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Posted by admin on Jun 30, 2018 in |
Marine environment is a complex habitat defined by a wide fluctuation in conditions such as pH, temperature, nutrient availability, osmotic pressure and salinity. Because of these various extreme environmental conditions, it harbors varieties of biodiversity such as bacteria, algae, fungi, coral reefs and sea weeds, as compared to terrestrial environment. For adaptation in these conditions marine organisms developed new adaptative strategies like synthesis of secondary metabolites. Exopolysaccharides (EPSs) is one of the important secondary metabolites produced by marine organisms. The present study focuses on the isolation of marine bacteria from different sites of Bhavnagar coast Gujarat, India and screening for EPSs producing marine bacteria by various approaches viz., using fluorescent Calcofluor white dye, Congo-red and trypan-blue agar plate assay method. Quantification of EPSs was done by using phenol-sulphuric acid method for total carbohydrate content. In this work marine bacterial isolate Terribacillus saccharophilus strain PS – 47 gave copious amount of EPSs 1052 µg/ml. Isolate will be further selected for use in various biotechnological...
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Posted by admin on Jun 30, 2018 in |
The skin covers a total surface area of approximately 1.8 m2 and provides the contact between the human body and its external environment. Transdermal route of drug delivery has gained great interest in pharmaceutical research as it overcomes many problems associated with the oral route of administration. Although the skin, particularly the stratum corneum presents a barrier to most drug absorption, it provides a large (1.2 m2) and accessible surface area for drug diffusion. Recently, various strategies have been used to augment the transdermal delivery of bioactives. Mainly, they include iontophoresis, electrophoresis, sonophoresis, chemical permeation enhancers, magnetophoresis, microneedles, vesicular systems (liposomes, niosomes, elastic liposomes such as ethosomes, transfersomes and transethosomes). Among these transethosomes appear to be more promising as they possess both lipophilic and hydrophilic regions and can accommodate drug molecules with a wide range of solubility. Transethosomes can deform and pass through a narrow constriction that is 5 to 10 times less than its own diameter. This high deformability gives better penetration of intact vesicles. These vesicles can...
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