Posted by admin on Jun 30, 2018 in |
Osteoporosis is a debilitating disease that affects many older people. Characterized by low bone mass and microarchitectural deterioration (MAD) of bone tissue, Fragility fractures are the hallmark of osteoporosis. There are potentially numerous nutrients and a dietry component that can influence bone health. Bone mineral consists of calcium phosphate, and phosphorus is as important as calcium in supporting bone augmentation and maintenance. Although typical adult diets contain abundant phosphorus, 10% to 15% of older women have intakes of less than 70% of the recommended daily allowance. Patients at the highest risk for fractures benefit from many approved treatments which can be given orally {alendronic acid, risedronatesodium, zolendronic acid, denosumab, raloxifene, hormone replacement theory (HRT)} which results in increased bone mineral density and reduction of fracture risk. This article initially overviews osteoporosis, including its definition, etiology, and incidence, and then provides some information on possible dietry strategies for optimizing bone health and preventing osteoporosis. The potential benefits of calcium, Vitamin D, Vitamin K, phosphorous and Vitamin C are briefly discussed, along with the different...
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Posted by admin on Jun 30, 2018 in |
Present study includes the detailed pharmacognostic evaluation in terms of macroscopic and microscopic study along with physicochemical, phytochemical and fluorescence analysis of Capsicum annuum L., an annual spice and member of family Solanaceae, commonly known as red chili. The pharmacognostic studies provide comprehensive data not only in the identification but at the same time is an excellent tool for the evaluation of quality of spices. The Fourier Transform-Infrared spectrophotometer (FT-IR) analysis and elements detection by scanning electron microscope-energy dispersive x-ray spectroscopy (SEM-EDAX) was also performed and noted to be quite helpful in evaluation, authentication and judgement of quality of C. annuum. The scanning electron microscope-energy dispersive X-ray spectroscopy (SEM-EDAX) technique has been used in the present studies to detect the concentration of trace elements. Results of the present study indicated comprehensive information to check, evaluate and standardized commercial samples by the manufacturers and supplier with respect to purity, identity, safety, quality of red chili and other...
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Posted by admin on Jun 30, 2018 in |
Repaglinide is used in the treatment of type 2 Diabetes mellitus and has very short half life. The patient compliance can decrease when larger doses are administered two to three times a day. Sustained release formulation which maintains a plasma level of 8-10 h might be recommended for daily administration of repaglinide. The main objective of the present study was to develop sustained release formulation using hydrophilic release retardant natural and synthetic polymers i.e., Ocimum basilicum seed mucilage and HPMC K4M alone and in combinations respectively. Direct compression technique was used to prepare tablets which were evaluated for precompression and postcompression parameters. Nine formulations were prepared in which F1-F3 were prepared using Basil seed mucilage, F4-F6 by HPMC K4M and F7-F9 using both the polymers (Basil seed mucilage and HPMC) at 1:3, 1:6 and 1:9 to the drug and polymer ratios respectively. F8 was selected as the best formulation which sustained the drug release upto 98.61% in 10 h out of nine formulations (F1-F9). The selected formulation which was...
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Posted by admin on Jun 30, 2018 in |
A new, simple, sensitive, accurate and precise RP-HPLC method was developed for the estimation of quetiapine fumarate in human plasma. Full factorial design was used for the optimization of an extraction method. The main effect of volume of deproteinating agent, speed of centrifugation, time of centrifugation and temperature of centrifugation was found to be significant at P<0.0001 on all the responses. After deproteinization, the drug was analyzed on a C18 (150 × 4.6mm, 5 µm) column using UV detector. The mobile phase consisting acetonitrile and phosphate buffer (pH 3) in the ratio of 50:50 (v/v) at a flow rate of 1.0 ml/min. The standard calibration curve was constructed in the concentration range of 5 µg/ml to 30 µg/ml and linearity was found to be 0.999. Irbesartan was used as the internal standard. The retention time of quetiapine fumarate and the internal standard was found to be 5.42 and 2.89 min, respectively. No interference peak was perceived. The high performance liquid chromatography method was successfully demonstrated as rapid and sensitive...
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Posted by admin on Jun 30, 2018 in |
Neem has become valuable plant in the world which shows the solutions for hundreds to thousands problems. Neem has become important in the global context today because it offers answers to the major concerns facing mankind. Neem has been extensively used in Ayurveda, Unani and Homoeopathic medicine and has become a centre of attraction of modern medicine. Azadirachta indica (neem) is a rapidly growing evergreen well known tree found generally in various regions of world like America, Africa and India. The aim of this review article provides information mainly on various pharmacological activities like anti-inflammatory, antimalarial, anti-bacterial, anti-allergic, antidermatic, antiulcer, antifungal, insecticidal, larvicidal and other pharmacological activities of neem plant and medicinal...
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