Posted by admin on Aug 31, 2023 in |
Iriflophenone 3-C-β-D glucoside is a Benzophenone derivative which can be obtained from various plant sources like Aquilaria crassna, A. sinensis, A. malaccensis, Cyclopia genistoides, Mangifera indica, Dryopteris ramosa etc. It can act as an important herbal active constituent as it has various pharmacological actions, such as Antidiabetic, anti-inflammatory, antioxidant, and antimicrobial agent. Some scientists demonstrated the antioxidant activity of Iriflophenone 3-C-β-D glucoside and have seen that this compound has no radical scavenging ability against DPPH [2,2-diphenylpicrylhydrazyl] but scavenged ABTS [2,2’-azino-bis(3- ethylbenzothiazoline-6-sulphonic acid)] and peroxyl radicals. So, it can be used as an anti- oxidant agent. From A. sinensis 8 compounds were isolated among which Iriflophenone 3-C- β-D glucoside was present. It is proved that all the isolated compounds have α-glucosidase inhibition activity stronger than acarbose, that is taken as positive drug control. Aqueous fraction of D. ramosa is used for so long by the inhabitants of the Galliyat region of Pakistan to treat their GIT ailments caused by bacteria. Scientists showed that Iriflophenone 3-C-β-D glucoside that is obtained from...
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Posted by admin on Aug 31, 2023 in |
Fatty acids produced by plants protect themselves from pathogens, such as multidrug-resistant bacteria. In the present work, crude extracts, and fatty acid fractions of four pteridophyte species from Assam, Northeast India, were evaluated for their antimicrobial properties, and the bioactive compounds were identified using GC-MS analysis. The crude extract of Pteris semipinnata (Ps), Lygodium microphyllum (Lm), Lycodium flexuosum (Lf), and Lycopodiella cernua (Lc) was found to possess antibacterial and antifungal activities. The lowest MIC and MBC values were 0.25 mg/ml and 0.5 mg/ml for the fatty acid fractions against most of the microbial test strains. The GCMS analysis revealed 21 compounds in Ps, 35 in Lm, 33 in Lc, and 52 in Lf fractions. The present work supports the use of fern species in traditional medicine and...
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Posted by admin on Aug 31, 2023 in |
Topical medications are frequently used to treat skin conditions. Antibiotic-resistant bacteria have emerged. As a result, the man has looked to nature for healing. Traditional medicines work better because they are less likely to cause side effects and are more effective. The Cocculu shirsutus and Tridax procumbens leaves were authenticated, dried, and extracted. Phytochemical screening and physicochemical analysis of extracts were done. The antimicrobial studies and in-vitro anti-inflammatory activity of extracts were carried out. The polyherbal gel was formulated by varying the concentrations of the gelling agents. The formulation was evaluated for physical appearance, visual homogeneity, pH, viscosity, and accelerated stability studies. Six batches of polyherbal gel were formulated using different gelling agents and varying concentrations. The F4 formulation showed the best results. Six batches of polyherbal gel were formulated using different gelling agents and varying concentrations. The best results were shown by F4...
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Posted by admin on Aug 31, 2023 in |
Urinary tract infection (UTI) is one of the most common infections affecting humans and is one of the leading causes of both community-acquired and nosocomial infections. The study’s objective was to assess the rate of de-escalation and the impact of de-escalation on cost and length of stay, antibiotics utilization pattern, and adverse effects of antibiotics in bacteremic UTI. A prospective observational study was conducted on 218 UTI patients in a tertiary care hospital in Trivandrum for 6 months. The results showed that the incidence of UTI is higher in females. The most common symptom was identified as fever, followed by dysuria. Escherichia Coli was the causative organism in most of cases. Inj. Cefoperazone and Sulbactum was the most frequently prescribed antibiotic. Gastric irritation was experienced by 1.8% of patients followed by exanthema in 0.5% patients. The rate of successful de-escalation was 26.9% while 73.1% failed de-escalation. A significant association (p-value < 0.001) was found between de-escalation failure and length of stay. According to our study, the absence of de-escalation...
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Posted by admin on Aug 31, 2023 in |
Opsonisation is the process of coating infections with antibodies to make them more receptive to phagocyte ingestion. Opsonization is a crucial step in host defence that prepares particles or complexes for easy ingestion by phagocytic cells. It has been acknowledged that activated macrophages could proactively capture opsonized nanoparticles in the bloodstream and then accumulate in the reticuloendothelial system (RES) organs. Based on this fact, a trapping strategy is proposed, transforming a normal nanoparticle into an opsonized attractant to target and regulate macrophage polarization. Developing an effective therapeutic approach against systemic infections linked to chronic immunodeficiency illness presents a significant problem for medical practitioners. Long circulatory carrier systems provide a practical substitute for dealing with the problems caused by systemic infections. The pathophysiology of opsonization is when the process is not occurring. Opsonization fights off foreign invaders like bacteria and viruses, supports self-tolerance, and inhibits autoimmunity. Self-tolerance is the ability of the immune system to recognize its self-antigens without mounting a response. However, the extent to which the carrier system has obscured the...
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