Posted by admin on Aug 31, 2015 in |
One of the major advances in vesicle research was the finding that some modified vesicles possessed properties that allowed them to successfully deliver drugs in deeper layers of skin. Transdermal delivery is important because it is a noninvasive procedure for drug delivery. Further, problem of drug degradation by digestive enzymes after oral administration and discomfort associated with parenteral drug administration can be avoided. An alternative approach to overcome the low oral bioavailability is to administer the drug by non oral routes such as buccal, nasal, vaginal, transdermal and parenteral. Among the above routes the transdermal delivery of ethosome is advantageous. Because it has good penetrability, ease of administration, rapid termination of the therapy and administrating to unconscious patients. Ethosome mainly contain phospholipids with higher concentration of ethanol. It can be used for systemic delivery of drug. It is beneficial to overcome the problem of frequent dosing due to shorter half-life of drugs. Prolonged release of the drug and increased bioavailability leads to significant reduction in the dose and hence...
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Posted by admin on Aug 31, 2015 in |
Objectives: To study the anti-convulsant potential of leaves of Psidium guajava Linn. in MES and PTZ induced convulsion in experimental animals. Materials and methods: The anticonvulsant potential of the ethanolic extracts of Psidium guajava Linn. (EEPG) were tested in the mice model of Maximal electroshock (MES) and Pentylenetetrazole (PTZ). In the MES model, seizures were induced by delivering electroshock of 50 mA for 0.2 seconds via a pair of transauricular electrodes using an electro-convulsiometer. In the PTZ model, seizures were induced by injecting 80 mg/kg i.p Pentylenetetrazole (PTZ). For MES model, parameters measured were – duration of hind limb tonic extension, total recovery time and percentage protection. For the PTZ model, parameters measured were –duration of onset of clonic convulsions, duration of clonic convulsions, percentage reduction of clonic phase, mortality percentage and seizure score. Results and Observation: The EEPG (200 mg/kg and 400 mg/kg) produced dose dependent anticonvulsant effect on MES induced seizures in albino mice, as suggested by reduction in the HLTE and total recovery time, and increase...
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Posted by admin on Aug 31, 2015 in |
Seasonal fluctuations are periodical series, and have impact on availability of active principles in medicinal plants hence, therapeutic efficacy also get influenced. The survey of several scientific studies published in scientific journals of international repute indicates this fact. The studies reported that essential oil component shows a rhythmic increase in oil production throughout the growing season and then a steady decline towards the winter hence, recommended late summer as the best collection time. In contrast other researchers concluded the winter as a best season for harvesting of essential oils containing plant parts. It is not only essential oil that influenced by the season but other important constituents like polyphenol, flavonoids, glycosides, alkaloids etc are also influenced significantly by seasons. There is no general rule for the harvesting time for better yield of specific secondary metabolites. Although several studies have been published indicating the effect of seasons on secondary metabolites but there is no compiled information representing the optimized season for the collection of pharmaceutically important constituents from different plant...
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Posted by admin on Aug 31, 2015 in |
Pulsatile drug delivery systems are developed to deliver drug according to circadian behavior of diseases. The product follow a sigmoidal drug release profile characterized by a time period of no release (lag time) followed by a rapid and complete drug release. Thus drug can be delivered at right time, in right amount and at right site of action by use of such approach. The potential benefits of chronotherapeutics have been investigated and established for number of diseases like asthma, arthritis, cancer, diabetes, epilepsy, hypertension, ulcer, hypercholesterolemia etc. Various capsular, osmotic, single and multiple unit systems that are modulated by soluble or erodible polymer coatings, rupturable membranes are available in market. These systems are beneficial for diseases showing chronopharmacological behavior where night time dosing is required or for the drugs having high first pass effect or having site specific absorption in GIT, or for drugs with high risk of toxicity or tolerance. These systems also improve patient compliance by decreasing dosing...
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Posted by admin on Aug 31, 2015 in |
The present study outlines a systematic approach for Formulation and Evaluation of Immediate release Tablets of Abacavir and Zidovudine tablet. Combination of anti retiro-viral creates multiple obstacles to HIV replication to keep the number of off springs low, reduce the possibility of superior mutations, decrease viral load and potentiate synergistic activity with one another, combining two drugs into one tablet reduces the number of individual medications1. To achieve this goal various prototype formulation trials were taken with varying compositions of diluents and disintegrant and evaluated with respect to their various quality control tests such as Thickness, hardness, weight variation, dissolution, disintegration, hardness and assay. The formula was finalized by comparing the In-vitro dissolution profile of all formulations with the respective individual marketed products. The in vitro release study was performed in 0.1N Hcl upto 60 min. Among all the formulations, formulation F6 release profile was good as compared to the other formulations. Forced degradation studies at 550C & Stability studies at 40±2ºC/75±5%RH (accelerated condition) for 1& 3 months indicated...
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