Posted by admin on Aug 31, 2022 in |
As a source of medicine, plants have always been exceptional. Ayurveda and other Indian texts discuss the use of plants to treat a variety of human illnesses, including cancer and diabetes. Thousands of plant species in India, which number in the tens of thousands, are thought to have medicinal use. Recent studies on plants described in historical writings or used to treat sickness have been carried out. An Indian medicinal plant of the Bignoniaceae family is Stereospermum suaveolens DC. It has traditionally been used as an analgesic, liver stimulant, astringent, wound healer, and antiseptic. Dashamularishta has the roots of this plant as one of its components. More research into the plant’s medicinal properties has been done than the isolation of its active components. Stereospermum suaveolens have been used to treat fevers and brain disorders for their antibacterial, antiprotozoal, and anti-inflammatory properties. An in-depth look at the chemistry and pharmacology of Stereospermum suaveolens is presented in this...
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Posted by admin on Aug 31, 2022 in |
Neuropathic pain (NP) is a chronic debilitating condition that affects all dimensions of health. Though pharmacological therapy is the main treatment of varied neuropathic pain conditions, not all neuropathic pain conditions respond well to drug therapies. Therefore, under-utilized non-pharmacological strategies were tried and implemented in chronic neuropathic pain subjects to provide adequate pain relief and restore functionality. This study aimed to assess the awareness of non-pharmacological interventions in neuropathic pain and to determine the attitude and practice towards the actual implementation of non-pharmacological modalities in attenuating pain symptoms of NP subjects. It was a Prospective, Observational study conducted on 100 OPD subjects of either gender aged 18-65 years with newly diagnosed chronic neuropathic pain conditions who agreed to participate in the study from January 2019 to June 2020 in the Pain Super-specialty clinic at Kempegowda Institute of Medical Sciences, Bangalore. Data were collected using a purposive sampling method, using a Self-administered, 14-item Questionnaire. The mean age of the study subjects was 44.68 years. 60.0% were aware of the existing...
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Posted by admin on Aug 31, 2022 in |
Doravirine, Lamivudine, and Tenofovir Disoproxil Fumarate belong to the class of anti-viral drugs and have been widely used in the treatment of HIV-I infection. Doravirine is a novel non-nucleoside reverse transcriptase inhibitor used in the combination of Lamivudine and Tenofovir Disoproxil Fumarate to effectively treat HIV/AIDS by overcoming the common resistance mutations without any possible drug interactions when co-administered. A literature review has reported few methods for the simultaneous estimation of Doravirine, Lamivudine, and Tenofovir Disoproxil Fumarate in combination with other antiviral drugs. The present investigation aimed to develop a simple, rapid, economical and stable indicating RP-HPLC method for the simultaneous estimation of Doravirine, Lamivudine and Tenofovir Disoproxil Fumarate in the pharmaceutical dosage form. The chromatographic separation was achieved on Kromasil C18 column with the dimensions of 250 x 4.6 mm, 5µm particle size, and maintained at 30 ˚C at a wavelength of 260nm. A combination of buffer (0.1% OPA) and Acetonitrile as mobile phase has optimized the method for efficient separation of drugs. Doravirine, Lamivudine and Tenofovir Disoproxil...
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Posted by admin on Aug 31, 2022 in |
Covid-19 associated mucormycosis rose sharply during India’s 2nd wave of coronavirus infections. The administration of immunosuppressive drugs led to increased susceptibility of patients to oppurtunistic diseases like mucormycosis. One of the causative species of mucormycosis is Rhizopus microsporus. For this study, we choose two chalcones and examined their ability to act as potential anti-mucormycosis agents by inhibiting the R. microsporus endo β-1,4-Mannanase protein. We studied their possibility to inhibit the SARS-CoV-2 main protease and RNA dependent RNA polymerase. The chalcones were docked against the proteins of interest using Autodock 4.0 followed by Molecular dynamics simulation. Our study revealed that 2’, 4’-dihydroxychalcone had the best docking with the endo β-1,4-Mannanase protein with steady root mean square deviation values and showed favourable docking with the SARS-CoV-2 proteins while passing all the drug likeliness filters. Thus 2’, 4’-dihydroxychalcone can be put through further verification to test its efficacy against the causative agents of mucormycosis and the Covid-19...
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Posted by admin on Aug 31, 2022 in |
The objective of the present investigation was to develop an alginate-HPMC K4M microbead-based gastro-retentive drug delivery system incorporating Famotidine for the treatment of gastrointestinal ulcers. The 32 full factorial designs were used for the optimization of famotidine-loaded floating microbeads. Two factors were evaluated, each at 3 levels; experimental trials were performed for all nine possible combinations. The amount of HPMC K4M (X1) and rotations of stirring speed (X2) were selected as independent variables. The % entrapment efficiency, % drug release at 12 hr, and % buoyancy were selected as dependent variables. The morphological properties, mean particle size, drug entrapment efficiency, drug loading, in-vitro buoyancy studies, in-vitro drug release, and in-vivo antiulcer activity of microbeads were all investigated. The effect of formulation variables on the response variables was statically evaluated by applying ANOVA at a 0.05 level using the software Design Expert® 13 (Stat-Ease, USA). The average size of optimized alginate-HPMC K4M microbeads was 0.86±0.35mm, with estimated entrapment effectiveness of 71.43± 0.21%, cumulative drug release of 98.75± 0.50% and percent...
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