Posted by admin on Aug 31, 2021 in |
Moringa oleifera and chywanprash are two main nutraceuticals used worldwide because of their large medicinal application. The quality of these nutraceutical products is in question, especially due to the inorganic contaminants like heavy metals. In the present study, six Moringa herbal powder and five chywanprash samples were collected in India and further analyzed for As, Cd, Hg, and Pb. All samples were microwave digested and analyzed by ICP-MS. In Moringa As, Cd, Hg and Pb were found in the range of 0.027-5.264 µg/mL, 0.014-0.039 µg/mL, 0.049-45.225 µg/mL and 0.323-12.487 µg/mL respectively. In chywanprash As, Cd, Hg and Pb were found in the range of 0.012-0.021 µg/mL, 0.004-0.029 µg/mL, 0.01-0.103 µg/mL and 0.06-0.171 µg/mL respectively. The concentration of these heavy metals were found to be more than the maximum permissible limit given by the WHO for herbal medicines. Hence strong regulatory guideline needs to be prepared to improve quality of...
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Posted by admin on Aug 31, 2021 in |
Aim: The present study was undertaken to screen the phytochemicals present in fruits of Grewia tiliaefolia and to evaluate the potential role of these fruits in the amelioration of cisplatin-induced nephrotoxicity in male Albino rats. Materials and methods: Ethanol extract of Fruits of Grewia tiliaefolia was prepared by hot extraction method. The prepared ethanol extract was subjected to preliminary phytochemical evaluation followed by TLC, HPTLC, HPLC and GC-MS analysis. The nephroprotective potential of the extract was screened at 200 and 400mg/kg b. w. in both curative and prophylactic regimens in male Albino rats. Nephrotoxicity was induced by single intraperitoneal injection of cisplatin at a dose of 5 mg/kg b.w. The nephroprotective activity was assessed by determining serum markers, urinary parameters, lipid peroxidation and antioxidant levels and his to pathological studies in renal tissue. Results: Upon preliminary phytochemical screening, the ethanol extract showed the presence of Proteins, flavonoids, Tannins, Terpenoids. HPTLC analysis resulted in a fingerprint of extract showing the presence of 14 compounds. TLC and HPLC revealed the presence...
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Posted by admin on Aug 31, 2021 in |
Background: Dolutegravir and Rilpivirine are two antiretroviral drugs that have been approved for the treatment of HIV Infection. An error-free, accurate, precise and valid reverse-phase liquid chromatography method was developed for the quantitation of Dolutegravir and Rilpivirine in its bulk form as well as in combined dosage form by forced degradation studies. Methods: Chromatographic separation of these two drugs Dolutegravir and Rilpivirine, was achieved with an INERTSIL ODS C18 (250 × 4.6 mm, 5 μm) reverse-phase analytical column with a 10 min analytical run time using a mixture of 0.1% OPA: Acetonitrile in the ratio of (60:40 v/v) as mobile phase. The mobile phase was streamed at a flow rate of 1.0 mL min-1 with a column temperature of 250 °C and detection wavelength was carried out at 230 nm. The retention time was found to be 3.4 min for Dolutegravir and 4.3 min for Rilpivirine. Results: The linearity limit of Dolutegravir and Rilpivirine was found to be in the range of 0.999 and 0.999. The method validation was...
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Posted by admin on Aug 31, 2021 in |
Excessive drug therapy, environmental pollutants, hepatic cancer and alcoholic intoxicants are the main causes of liver disorders. The hepatic disorders/toxicity can occur by several mechanisms like cytochrome P450 activation, lipid peroxidation, induction of nitric acid synthase, mitochondrial dysfunction, activation of pro-inflammatory mediators and bile acid-induced liver cell death. In spite of consistent human effort and drug discovery, the modern drug has very little to offer. (Prunus armeniaca) is commonly known as Khubani or moon of the faithful or Egg of the sun, which is used as folk medicine in traditional Indian medicinal system as well as worldwide medicinal system, belongs to the family Rosaceae. Prunus armeniaca fruit is the rich source of vitamin, carbohydrate, thiamine, niacin, iron, organic acids, phenols and volatile compounds viz. benzaldehyde, esters, norisoprenoids, terpenoids and minerals. The seed of Prunus armeniaca contain very small amount toxic hydrogen cyanide amygdalin, present in bitter prunus armeniaca kernels which are prescribed as anticancer drug, in asthma, cough and constipation. Prunus armeniaca is having some reported activities like anticancer,...
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Posted by admin on Aug 31, 2021 in |
Microsponges are novel drug delivery systems made up of cross-linked spongy, polymeric, porous, spherical microspheres particles which vary in size from 5-300 μm. This delivery system as the advantage of producing controlled release formulations of poorly soluble drugs. It increases drug stability, reduces side effects and modifies drug release profiles making it a versatile drug delivery vehicle. These active micro sponges can entrap a wide variety of substances and be incorporated into formulations, such as capsules, gels, liquids, creams and powders and share a broad package of benefits. This article presents a broad review of Micro sponges delivery system (MDS), discussing its characteristics, benefits, different preparation methods (Liquid-Liquid Suspension Polymerization, Quasi-Emulsion Solvent Diffusion) and release mechanisms. It also covers different characterization parameters like particle size, size distribution, morphology, surface topography, loading efficiency, production yield, compatibility studies, true density, in-vitro release studies and MDS systems applications in oral, topical cosmetics bone and...
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