Posted by admin on Aug 31, 2020 in |
The present paper reveals the socio-economic benefits for the peoples of the Uttarakhand state. The demand for medicinal and aromatic plants of Uttarakhand is quite inflated, and many of these plants grow only in the Himalayan states. The State has diverse agro-geo climate conditions, which is most suitable for Medicinal and aromatic plant cultivation. Uttarakhand is blessed with a variety of soils and agro-climatic conditions, ranging from Sub-Tropical to Alpine, which is a mega biodiversity hotspot for a wide range of wild and cultivated Medicinal and aromatic plants. Due to the low point of agricultural production, lack of industrial development, poverty, and unemployment, peoples migrate to exploit biodiversity to improve their socio-economy. There is a socio-economic pressure to migrate on the plain districts for better livelihood...
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Posted by admin on Aug 31, 2020 in |
The L-Glutaminase enzyme is a therapeutic agent that can be employed for the treatment of human cancer, specifically lymphocytic leukemia. Microbes are exploited commercially to produce L-Glutaminase on a large scale. The L-Glutaminase is an economic anti-cancer drug and can be easily administered into patients. The L-Glutaminase is also employed in food industries in the processing of fermented foods. In the present paper, the L-Glutaminase enzyme structure was developed and validated using web-based computational tools. The sequence (FASTA format) of the L-Glutaminase enzyme was obtained from UniProt Knowledgebase. The FASTA format sequence of the L-Glutaminase enzyme was used as input data in the SWISS MODEL workspace to develop the structural model of L-Glutaminase by automated mode. The quality of the modeled structure of the L-Glutaminase enzyme was checked in PROCHECK server and SPDBV (Swiss PDB Viewer) and validated. Further, L-Glutaminase activity can be enhanced using advanced bioinformatics tools. Such L-Glutaminase with improved activity can be produced by...
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Posted by admin on Aug 31, 2020 in |
Notable progress has been made in methods that encourage the use of PCR as a rapid and accurate tool in quality evaluation of pharmaceuticals. In this study, monoplex and multiplex PCR based assays were developed and compared with standard conventional methods for rapid detection of three specified topical indicator pathogens, Pseudomonas aeruginosa, Staphylococcus aureus, and Candida albicans, in nonsterile pharmaceutical preparations. The detection limit of monoplex PCR assays for the microbial targets was achieved at 100 fg purified DNA and 10 CFU/ml for Pseudomonas aeruginosa, and 1fg purified DNA and 10 CFU/ml for each of Staphylococcus aureus and Candida albicans. No change in the detection limit for CFU/ml of the three tested indicator pathogens was obtained upon using mPCR assays. The results of applying both conventional and PCR detection methods for different cream and lotion preparations revealed a 100% correlation between both methods. The PCR based detection method can be completed in 8 h versus 5-6 days in case of conventional methods, but the former can’t differentiate between viable...
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Posted by admin on Aug 31, 2020 in |
Background: Self-Nanoemulsifying Drug Delivery System (SNEDDS) has been employed extensively by the formulation of scientists to tackle the low solubility issues of various drugs and lift the bioavailability profile. But the potential of SNEDDS is not limited to augment the dissolution profile only. Objective: The objective of the study was to develop, optimization, and characterization of SNEDDS of anti-lipase inhibitors. Method: Orlistat was added in an accurately weighed amount of oil into a screw-capped glass vial and heated in a water bath at 40 ºC. The surfactant and co-surfactant were added to the oily mixture using positive displacement pipette and stirred with a magnetic bar. The formulation was further sonicated for 15 min and stored at room temperature until its use in subsequent studies. A 23 full factorial design was selected because an experiment may be designed to focus attention on a single independent variable or factor. Results: The drug loading efficiency for all Orlistat SNEDDS formulae was found in the range of 92.37% ± 0.75% (PF1) to 99.09%...
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Posted by admin on Aug 31, 2020 in |
Innovation in technology is required to change the world. Bioelectronic medicine is the consolidation of molecular medicine, neuroscience, engineering, and computing to develop a device to diagnose and treat diseases. The mechanisms of Bioelectronic medicine for neural control of a biological process that underlie disease and the development of devices to modulate these specific neural circuits as therapy using electrons instead of drugs. Bioelectronic medicine has emerged at a convergent epicenter in health care, technology, and science. Bioelectronic medicine is a new way to treat disease. Today patients are treated by either drug, which can lead to a side effect or drive up costs, which can mask pain signals but they usually can’t mask the central cause of disease. With the rapid rise in technology for the precision detection & modulation of electrical signaling patterns in the nervous system is a new class of treatment known as bioelectronic medicines. Specifically, the peripheral nervous system will be at the center of this advance, as the functions it controls in chronic...
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