Posted by admin on Aug 31, 2018 in |
The macro and micro nutrients content estimation was carried out for leaves of indigenous medicinal plant Murraya koenigii (L.) Sprenge collected from different places of North Karnataka region viz. Bidar, Kalaburagi, Shahapur, Sandur and Kappathgudda. About few kg of leaves of Murraya koenigii (L.) Sprenge plant material was collected and then they were washed in deionized water to eliminate contamination due to dust and environmental pollution. The washed leaves were air-dried under shade for more than a monthand then grinded to get fine powder. The powdered sample was heated at higher temperature to get ash. The obtained ash was digested with conc. HCl, deionized water and ash (25:25:1:950). The contents of macro, micro nutrients and harmful heavy meats such as K, Ca, Mg, Fe, Mo, Cu, Mn, Zn, Al, V, Cd and Ti were estimated by an analytical atomic absorption spectrometry technique. The experimental results confirmed the presences of mineral nutrients which are beneficial to the human body and are within the limit. The heavy metal which are harmful...
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Posted by admin on Aug 31, 2018 in |
The dry emulsion formulation aims to improve the solubility and dissolution of mefenamic acid. Dry emulsions are attractive because they are physically and micro biologically stable formulations. They represent a potential oral drug delivery system for lipophilic and low soluble drug substances. Dry emulsions can be prepared by spray drying, lyophilisation and rotary evaporation. Dry emulsion prepared here was by lyophilisation using capryol as the lipid phase and HPMC as the carrier. Mefenamic acid is the drug of choice which belongs to non-steroidal anti-inflammatory drug category. It is used as anti-pyretic, analgesic and anti-rheumatic and is used in the treatment of mild to moderate pain, including menstrual pain. The dry emulsion is formed by freeze drying method and incorporated in HPMC (hydroxyl propyl methyl cellulose) capsules, which provides a vegetarian environment and is a good alternative to gelatin. The formed dry emulsion formulation has been evaluated for the respective parameters in comparison with the marketed variant and the results are...
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Posted by admin on Aug 31, 2018 in |
This manuscript presents the application of a detailed set of analytical technologies to the content of assorted micronutrient supplement and mineral supplement products on the market in the city of Concepcion, Chile. We applied TXRF as a screening technique for the evaluation of 1) The vitamin B-12 content in multivitamins and 2) the elemental composition (P, K, Ca, Mn, Cr, Fe, Cu and Zn) in mineral supplements. The analyzed 16 products (10 sold as pills, 3 as syrups, and 3 as solutions for intramuscular injections), were acquired directly from drugstores without medical prescription. They were processed in 3 different laboratories in order to avoid systematic errors. In the samples we evaluated: 1) The presence of the specified elements, 2) The correlation between the labelled contents and our evaluations; and 3) The possible presence of harmful elements for human health. In this study few anomalies were found: 1) in some products there are significant differences between the concentrations labelled and our evaluations. 2) The absence of cobalt in four of...
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Posted by admin on Aug 31, 2018 in |
Ionotropic gelation, a characteristic property, has become one of the easy, simple and mild ways of encapsulating variety of drugs, enzymes and proteins, prepared by various polysaccharides. The externally cross linked beads with calcium chloride and zinc chloride were suitable for water soluble and low molecular weight drugs. Insulin, encapsulated in a calcium pectinate gel beads by dispersing the insulin and core cross linking agent in a Solution of pectin, beads are prepared by dropping the dispersion in calcium chloride by inotropic gelation. The purpose of study was to improve the entrapment efficiency of high molecular weight drugs like insulin with internally cross-linking agents like calcium carbonate. Calcium pectinate beads containing insulin was prepared by surface cross linking with 1% and 5% w/v calcium chloride solution using calcium carbonate as internal gelling agent. Beads obtained using 1% w/v calcium chloride solution showed more drug entrapment than 5% calcium chloride solution. The core and surface cross linking of pectin beads improves drug loading by about 10 – 20% compared to...
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Posted by admin on Aug 31, 2018 in |
This research aimed to determine the antibacterial activity of methanolic, aqueous, chloroformic and petroleum ether extracts of Rubia tinctorum roots against two gram positive and two gram negative bacteria using agar well-diffusion method. The minimum inhibitory concentration (MIC) was determined using microdilution method. Extracts were dissolved in DMSO to obtain a concentration of 10% (w/v), and the density of bacterial suspension was 1.5 × 108 cfu/ml. Results showed that methanolic extract showed antibacterial activity against both gram negative and gram positive bacteria with minimum inhibitory concentration ranging from 0.1562 to 0.3125 mg/ml, while aqueous extract showed no activity against the tested bacteria. However, chloroformic extract showed antibacterial activity only against Escherichia coli with minimum inhibitory concentration value of 2.5 mg/ml. But petroleum ether extract showed antibacterial activity against Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus with minimum inhibitory concentration ranging from 0.3125 to 1.25 mg/ml. But in conclusion, methanolic extract was the most effective against all tested bacteria. Further studies are needed for pharmaceutical...
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