Posted by admin on Aug 31, 2017 in |
Objective: To study prescribing pattern for acute respiratory infections in children attending outpatient department of Paediatrics, J.L.N. Hospital, Ajmer, Rajasthan. Material and Method: The study was carried out retrospectively by analyzing the copies of prescriptions of patients who had visited the O.P.D. of the paediatrics department of J.L.N. Hospital Ajmer. A total of 350 prescriptions having written diagnosis ARI/URTI/common cold were selected for study. Information on demographic profile and treatment were spread over three different age groups (i.e. Neonates: up to one month of age, Infants: 1 month to 1year and Children: 1-14 years). Each prescription then was analyzed as per objectives of study. Results: Male patients were more as compared to females and most of the patients were in the age group of 1-14 years. Antihistaminics were the most frequently prescribed class of drugs (28.52%) followed by antimicrobials (26.35%). Antihistaminics constituted 63.08% of respiratory drugs prescribed. Antimicrobials were prescribed in 86.57% of the prescriptions and Cefpodoxime was the most frequently prescribed antimicrobial agent followed by Amoxicillin-clavulinic acid combination....
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Posted by admin on Aug 31, 2017 in |
Microspheres containing Repaglinide was prepared by emulsion solvent evaporation technique using two types of surfactants Tween 80 (polysorbate 80) and Span 80 (Sorbitanmonooleate 80). The effect of change in the type and surfactant amount on the size and drug release from the microspheres was investigated. The release of Repaglinide from the microspheres exhibit diffusional characteristics and closely follows Higuchi Model and also highly correlated with first-order release model. The in-vitro release study was performed in pH 6.8, phosphate buffer Solution and 0.1N HCl. Scanning electron microscopy study revealed that the microspheres were spherical and porous in nature. In vivo testing of the microspheres in diabetic albino rats demonstrated significant antidiabetic effect of Repaglinide. Repaglinide loaded microspheres expected to give new choice for safe, economical formulation for effective management of NIDDM. A clear correlation between the types of surfactant on mean diameter of the microspheres was found. When Span 80 was used, the microspheres were smaller in size as compared to those obtained using Tween 80, while there was a...
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Posted by admin on Aug 31, 2017 in |
Self nano-emulsifying system drug delivery system (SNEDDS) is promising for drugs of BCS class II. The objective of present study to develop self nano-emulsifying drug delivery system for Lipophillic drug Telmisartan (antihypertensive drug), labrafil 1944, Kolliphor ELP: Span 80 (1:1) and PEG 400: Ethanol (1:1) was chosen as oil, Surfactant and Co-surfactant as they show higher solubility for Telmisartan. Screening of Surfactant, Co-surfactant done by percent transmittance and were also observed for turbidity or phase separation visually. Pseudo ternary phase diagram were constructed to identify the self emulsifying regions and also to establish the optimum concentration of oil, surfactant and co-surfactant. Box bhenken desine applied for optimization of formulation. Prepared formulation further Characterization done. Percent Drug Content found 99.71, thermodynamic stability studies show homogenous and no phase separation, Emulsifying Study performed transparent appearance after 24 hr, for robustness Dilutability in water and 0.1N HCl give Percentage Transmittance 99.5 and 100, conducting in vitro dissolution test compared with marketed preparation in stimulated gastric (S.G.F) pH 1.2 showed Percent Drug Release...
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Posted by admin on Aug 31, 2017 in |
Coleus forskohlii is an herb historically used in Ayurvedic medicine. Nowadays Coleus forskohlii is used as a fat burning supplement in various formulations and available in the Indian market. Forskolin the main constituent of this plant is used to treat allergies, skin conditions such as eczema and psoriasis, painful menstrual periods, irritable bowel syndrome (IBS), urinary tract infection (UTI), bladder infections, advanced cancer, blood clots, sexual problem in men, insomnia, and convulsions. Healthcare providers sometimes give forskolin intravenously (by IV) for heart failure. Some people breathe in (inhale) forskolin powder for asthma. Forskolin drops are used in the eyes to treat glaucoma. Because of its wide use, this plant some time been adulterated with its species and other varieties. The standardisation parameters are important for this plant in every herbal formulation. With the developments in modern instrumental methods it is high time for the herbal drug manufacturers to come out with the standard level of this drug to be included in the formulation. An extensive study of phytochemical constituents...
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Posted by admin on Aug 31, 2017 in |
2, 6-dithiol-4-methylphenol (DTMP) is proposed as an analytical reagent for the extractive spectrophotometric determination of molybdenum (V). DTMP in the presence 2, 6- bis (N, N-dimethylaminomethyl)-4-methylphenol (AP) forms red colored complex with molybdenum (V) in the pH range 4.8 – 5.8. The Beer’s law was applicable in the range 0.4-22μg mL−1. The dark red Mo-DTMP-AP complex shows a maximum absorbance at 525 nm, with molar absorptivity of 5.21× 104 dm3 mol−1 cm−1 and Sandell’s sensitivity of the complex obtained from Beer’s data is 1.84 ng cm-2. The composition of the Mo (V)-DTMP-AP complex is found to be 1:2:1 (Mo: DTMP: AP). The interference of various cations and anions in the method were studied. The results of the prescribed procedure applied for the determination of the micro amounts of Mo (V) in plant, water and soil samples are...
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