Posted by admin on Aug 31, 2017 in |
Context: Ziziphus mistol (mistol) fruits and their derivate product (arrope) have been traditionally used as food and in folk medicine for the treatment of a wide variety of diseases including bronchopulmonary disorder. Objective: The objective of this study is to evaluate the antitussive and expectorant effects of Z. mistol ethanol extract (EE), aqueous extract (AE) and arrope (Ar). Materials and Methods: The antitussive activity was evaluated using two models against ammonia and citric acid induced cough in rats. The expectorant activity was evaluated by volume of phenol red secretion in rats’ tracheas. The tested doses of extracts were of 250, 500 and 1000 mg/kg, (p.o.). Results: The aqueous extract and arrope showed the highest activity in all tested models. The arrope, at 1000 mg / kg, proved to be more effective with inhibitions of 79.69% and 93.75% in the number of coughs induced by ammonium liqueur and citric acid, respectively, while it was similar to codeine. Expectorant activity showed an 87.73% increase in red phenol secretion at the same dose,...
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Posted by admin on Aug 31, 2017 in |
NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival. Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases and improper immune development. The main objective of the present research work was the synthesis of N-(4-{[5-(substituted phenyl)-1,3,4-oxadiazol-2-yl] methoxy}phenyl) acetamide derivatives and to evaluate the hepatocytes regenerator potentiality by molecular docking with 2V2T-NF-KB and as well as In vivo methods and the synthesized compounds were characterized by IR, NMR, and Mass spectroscopy. The in-vivo Hepatoprotective activity was carried out by using albino rats where CCl4 was used as a hepatotoxin. Molecular docking is performed to find out the binding affinity or molecular interaction energy (kcal/mol) of docked compounds. In silico molecular docking studies displayed the binding energies: -5.17, -5.52, -5.40, -4.60, -4.60, -4.87, -3.42, -3.85 k.cal/mol, of the synthesized compounds (AB1-AB8) which indicated that the compound had the high binding affinity towards the 2V2T-NF-KB protein and inhibit the NF-KB protein function in comparison with...
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Posted by admin on Aug 31, 2017 in |
Aging is among the phenomena more commonly discussed in world health in recent years. Disability is a good indicator to measure health status in the aging population. Accordingly, the primary objective of this study was to determine the prevalence of disability and its relationship with demographic characteristics of the elderly in Zahedan city in Iran in 2016. This is a cross-sectional descriptive-analytic study. Using two-stage random sampling, 400 seniors were selected in Zahedan and were studied. A researcher made questionnaire was used to collect demographic information and disability study instruments included WHODAS – 36 items without time code. Collected data were analyzed using the SPSS version 16 software using the chi-square test. Of 400, 218 individuals were female and182ones were male and the mean age of the participant’s was 73.21 ± 6.82 years old. The overall prevalence of disability among the elderly in Zahedan was 62.3%. The prevalence of disability had a significant relationship with age, education, occupation and income level (p < 0.05), whereas no relationship was observed...
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Posted by admin on Aug 31, 2017 in |
Murrels are very often affected by Epizootic Ulcerative Syndrome (EUS) and it causes huge loss to the capture and culture sector. The principal infectious agent of this infestation is a fungal species, Aphanomyces invadans. Different fungal species were isolated from EUS infected Channa punctatus fish from Hasanparthy Lake of Warangal, Telangana, India. Aspergillus flavus, Fusarium solani, Rhizophus stolenifer, Aspergillus fumigatus, Penicillium chrysogenum, Aspergillus niger and Trichoderma viridae were most isolated groups. Isolates have been obtained and ability to induce dermal lesions in infectivity studies make fungi is one of the likely primary aetiological agents that could be triggering the initiation to EUS. Fungi was observed as persistent infections in fishes evidenced by their presence in cell culture also require further investigations for their role in predisposing the freshwater fish of C. punctatus. The environmental conditions were also found in fluctuation during the winter season. In the present study isolation of fungal pathogens from infected fish like Aspergillus flavus, Fusarium solani, Rhizophus stolenifer, Aspergillus fumigatus, Penicillium chrysogenum, Aspergillus niger and...
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Posted by admin on Aug 31, 2017 in |
It is well known ionizing radiations produce deleterious effects on humans. In spite of research efforts for the past several years, today we do not have a radio protective agent that meets all the prerequisites like produces no cumulative and irreversible toxicity, offers effective long term protection, possess a shelf life of 2-5 years and can be easily administered. In recent years, attention has been turned to phytochemicals due to their antioxidant properties. This review focuses on the radio protective potential of resveratrol [trans-3, 5, 4’- trihydroxystilbene], a phytoconstituent, mainly found in Vitis vinifera. In particular, it aims to highlight the detailed studies, both in vitro and in vivo, that have been carried out on the radio protective capability of resveratrol. It also focuses on the different possible mechanisms through which resveratrol acts in response to ionizing radiations. Previous studies show both positive and negative aspects of resveratrol on radioprotection. But a thorough analysis including earlier studies and our own preliminary studies clearly support that resveratrol is an attractive...
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