Posted by admin on Aug 31, 2017 in |
Inflammation is an inflammatory process where histamine, kinin, prostaglandins and slow release substances are produced in the tissue of the body to cause irritation or injury. It consist three phases, dilation and increased permeability of small blood vessels resulting in oedema and swelling, emigration of leucocytes from venules, capillaries and cellular infiltration, proliferation of fibroblasts and synthesis of new connective tissue to repair the injury. Present study deals anti-inflammatory activity of extracts of Woodfordia fruticosa stems bark in animal models by mercury displacement volume method. Paw oedema was produced by injecting in a 0.1ml volume of formalin into the sub plantar tissue of the rat hind paw foot. The extracts of petroleum ether, chloroform, ethanol and aqueous extracts were administered orally to the albino rats in their respective groups. Test drugs were given at a dose of 200mg/kg according to their body weight. The results of aqueous extract of barks exhibited statistically significant (**P<0.01 and *P<0.05) anti-inflammatory activity in albino rats. Maximum percentage inhibition had been found in aqueous...
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Posted by admin on Aug 31, 2017 in |
The traditional health care system has been significantly used from ancient time. The rural people of Purba Medinipur, West Bengal still continue to depend on indigenous plants to cure their different types of primary health treatment. The present study explore 79 plant species belong to 41 families are systematically used in traditional health care system. Information was collected by the structures questionnaire, consultation and interviews with rural people, knowledgeable persons and women folk. The plants are principally used for the treatment of digestive disorder (24.4 %), respiratory trouble (25.64 %), dysentery (16.66 %), bleeding (12.8 %), snake and insect bite (11.53 %), skin infection (12.8 %) and sugar control (10.25 %). These wild medicinal plants are declining in number due to demolition and unscientific collection of plants. There is a requisite need to conserve the indigenous medicinal plants. This document will help to prepare a database of valuable indigenous plants and their issues for...
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Posted by admin on Aug 31, 2017 in |
A drug dosage form is very important in delivering the drug in proper dose in most appropriate form. The capsule shell is an excellent barrier to air, and it also has some other advantages such as being easy to swallow and tasteless, flexibility of formulation etc. The use of the hard gelatin capsule dosage form may perhaps be an alternative to overcome the problem, which the hygroscopicity of the extracts may pose. Present study was envisaged to develop a polyherbal formulation as capsule. The results obtained by the thermo analytical techniques showed no chemical incompatibility between capsule shell and herbal extract. The results were further confirmed by IR spectroscopy. The herbal capsule was stored at different temperatures viz., 25 0C, 40 0C and 50 0C for shelf life evaluation. The percentage alkaloid content for day zero was taken as 100% and accordingly, the percentages were calculated for all the other days. The organoleptic properties of the herbal capsule remain unchanged at tested temperatures throughout the stability study. Likewise, pH...
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Posted by admin on Aug 31, 2017 in |
Quality by Design [QbD] is a science based approach widely used in industry to continually monitor and improve the quality of product. It is a modern risk based strategic framework of all the aspects related to quality. ICH guidelines Q8 to Q11 summarizes all the different perspectives of quality by design system in required depth along with ways to implement it. This review in all focuses on the general terms of QbD its meanings and application along with different wide range applications of the QbD to pharmaceutical fields like Analysis, Formulation, Design and Technology development, Control Strategies etc. Also it includes a short view over the application of Various QbD tools like PAT, CAPA and HACCP in Pharmaceutical industry along with their importance in the Quality aspect of Pharmaceutical products. It also tries to cover the major aspects to be concerned while selecting the wide ranges of designs and statistical tools while employing QbD to a Particular aspect of Pharmaceutical...
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Posted by admin on Aug 31, 2017 in |
This paper describes a new, simple, precise, and accurate HPTLC method for simultaneous estimation of Oxyclozanide and Levamisole hydrochloride as the bulk drug and in tablet dosage forms. Chromatographic separation of the drugs was performed on aluminium plates pre-coated with silica gel 60 F254 as the stationary phase and the solvent system consisted of Toluene: acetone: ammonia (5:5:0.04 v/v/v). Densitometric evaluation of the separated zones was performed at 225 nm. The two drugs were satisfactorily resolved with R F values 0.28± 0.007 and 0.49 ± 0.009 for Oxyclozanide and Levamisole hydrochloride, respectively. The accuracy and reliability of the method was assessed by evaluation of linearity (400-1200 ng/band for Oxyclozanide) and (200-600 ng/band for Levamisole hydrochloride), precision (intra-day % RSD was 1.20 and inter-day % RSD was 1.51 for Oxyclozanide, and intra-day % RSD was 1.22 and inter-day % RSD was 1.52 for Levamisole hydrochloride), accuracy (0.556 for Oxyclozanide and 1.31 for Levamisole hydrochloride), and specificity in accordance with ICH...
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