Posted by admin on Aug 31, 2017 in |
Sintering technique, a relatively new, convenient, economic process for making polymeric matrices for controlled release is described here. The objective of the present investigation was to prepare thermally sintered matrix tablets of Atenolol using Eudragit RS 100 as sintering polymer and to study the effect of thermal treatment on drug release; physiochemical properties of the prepared tablets. The tablets are prepared by direct compression method. The compressed fluffy matrices were subjected to thermal treatment at three different constant temperatures like 60 °C, 70°C and 80°C for two different periods like 1.5 hr and 3 hr in hot air oven. The sintering condition markedly affected the drug release characteristics of prepared matrix tablets. Drug release rate was found to be inversely related with the sintering temperature and sintering duration. Hardness of tablets was found to be increased with increasing sintering time and temperature; whereas friability was decreased with sintering. Both percent water uptake and percent erosion of sintered tablets decreased with increase in sintering condition. Based on the evaluation tests...
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Posted by admin on Aug 31, 2017 in |
In recent decades, advances in nanoscience have resulted the rapid development of many novel technological applications for nanoparticles (NPs) in various in Biomedical Sciences. Iron is essential for eukaryotic biochemistry and is an important element in several metabolic processes such as, carrier for oxygen transportation, cell respiration, synthesis of genetic material and protein synthesis. The nematodes Caenorhabditis elegans (C.elegans) represent an excellent organism to investigate the phenotypic effect of different type of nanomaterials on the molecular, cells and entire organism level. C.elegans is widely used in studies of homeostasis, neurolagenerative and metal toxicity. The size of iron oxide and other nanoparticles plays a major role in target cell uptake and elimination from the body. The excess iron damage nucleotides (DNA/RNA) and Protein due to catalyzes the generation of Reactive Oxygen Species (ROS) , while cellular iron deficiency causes cell cycle arrest and cellular death of an organism. Systematic storage and trafficking is required to regulate supply of iron while preventing it from catalyzing unwanted reactions. We have used 36...
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Posted by admin on Aug 31, 2017 in |
The present study elucidates the secondary metabolite profile of leaves of Pseudarthria viscida, one of the main ingredient of dasamula in Ayurveda. Alkaloids, phenolic compounds and flavonoids were estimated in different solvent-extracts. Acetone extract of leaves showed highest content of phenols and flavonoids. The leaves are quite rich in alkaloids and is found to be 1.9 mg g-1. GC-MS analyses revealed the presence of 20 major volatile organic compounds and were identified by their mass fragmentation pattern in comparison with NIST library. Most of the compounds have antioxidant, anti-inflammatory, antimicrobial and anticancer properties. The present study has identified a major compound Neophytadiene which is a well-known enzyme...
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Posted by admin on Aug 31, 2017 in |
Bacterial pathogens are known to pester Mankind from times immemorial; even though significant efforts in getting rid of these harmful microbes have been made the results are very faint with only few organisms that have been eradicated, such as Small pox virus. But the efforts to eradicate bacterial diseases have shown no passable results as in case of viruses. This is due to the exceptional adaptation and transformation abilities of bacteria to varying environmental Conditions. Though a large number of antibiotics are being used from decades now, there are no affirmative solutions available due to resistance developed towards antibiotics by these bacteria. This resistance developed by the bacteria calls for dire necessity to discover new drugs which can at least reduce the hazards posed by these microbes if not eradication. Hence in this study we have focused on bio prospecting of Clerodendrum paniculatum and Saraca asoka against the highly virulent and extremely adaptable organisms E. coli and K. pneumoniae which currently pose a severe threat to humans due to...
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Posted by admin on Aug 31, 2017 in |
A series of novel 2-Benzamido-3-(4-nitrophenyl)-N’-(substituted) benzylidene-acrylohydrazide (4a-l) analogues were designed by incorporating the few pharmacophoric fragments to enhance the activity profile of molecules. Title compounds were synthesized by the microwave irradiation of α-Benzamido-(4-nitro)-cinnamahydrazide (3) reveals with aromatic/ heteroaromatic aldehydes under acidic conditions, characterized by IR, 1H & 13C NMR, Mass and evaluated for antimicrobial activity by using Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Bacillus subtilis and Candida albicans strains. Compounds 4e and 4k exhibited significant protection against bacterial strains (MIC: 3.12-50µg/ml; 3.12-100µg/ml respectively) and compound 4h showed better activity (MIC: 12.5 µg/ml) against fungal strain. And also molecular docking interactions with FAB protein for evaluating the antimicrobial activity was done by using XP GLIDE module of Schrodinger suite and this study highlights, all the analogues exhibited significant affinity towards the 5BNM (FAB Protein) have good docking scores (-4.51 to -8.78) than standard drug ciprofloxacin (-4.74). Of the 12 new analogues, compound 4e was identified as most active ligand with good activity profile against bacterial strains and also have higher...
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