Posted by admin on Aug 10, 2010 in |
Colocasia esculenta belonging to family araceae popularly knows as “taro”, is very useful medicinal plant described by Charaka as an anti-inflammatory plant. An experiment was carried out to study the antimicrobial activity of chloroform and methanol extract of Colocasia esculenta plant by agar diffusion method. Zone of inhibition produced by chloroform and methanol extract in dose of 20, 10, 5, 2.5, 1.25, 0.625, 0.3125 mg/ml against some selected strains was measured and compared with standard antibiotics tetracycline in dose of 5, 2.5, 0.625, 0.3125, 0.15625, 0.078072...
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Posted by admin on Aug 1, 2010 in |
Yoga and exercise are an efficient way of declining patients of hypertension in present and in future. However it has been shown that Non-pharmacological intervention prevent the rising blood pressure and reduce it up to maximum extent, near to the normal. This experiment was designed to determine effectiveness of Yoga and exercises therapies to control blood pressure of hypertension patients. The objective was to employ these Non pharmacological therapies to know it’s effectiveness in treatment of hypertension along with pharmacological therapies in conventional way. We tested the short-term efficacy and feasibility to the treatment of hypertension in a small South Gujarat’s industry employees who are living under modern life-style. This was follow-up by physician for 12 months. Of 1031 a small South Gujarat’s industry employees screened, 221 individuals (aged 35 to 60 years) were selected with hypertension. Mental and physical stress-reduction approaches (Meditation and progressive muscle relaxation) were compared with a life-style modification education control program and with each other. The primary outcome measures were changes in clinical diastolic...
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Posted by admin on Aug 1, 2010 in |
A series of 3- (5- substituted phenyl- 1, 3, 4- Oxadiazol- 2- yl) pyridines was designed, synthesized and characterized for evaluation of potential antibacterial activity against Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Klebsiella species and antifungal activity against Candida albicans. Structure-activity relationship led to the conculsion that compound IVb, and IVe exhibited good antibacterial activity against Bacillus subtilis and Staphylococcus aureus and comparatively poor activity against Klbesiella species and Escherichia coli. Compound C exhibited antibacterial activity against Staphylococcus aureus and very poor activity against rest of organism. Compounds IVa, IVb and IVe showed poor antifungal activity against Candida albicans and compounds IVc and IVd showed no significant antifungal activity. The interesting antimicrobial profile of compound IVb and IVe led us to select this derivative for further development. Present research our expected compounds were given below....
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Posted by admin on Aug 1, 2010 in |
AIM: The aim of this study was to analyze the efficacy and safety of concurrent chemotherapy with Cisplatin, Paclitaxel and radiotherapy on survival, functional and quality of life outcomes in locally advanced carcinoma of larynx. MATERIALS & METHODS: From June 2004 to Sep 2006, seventy four inoperable, previously untreated, histopathologically proven, locally advanced patients of carcinoma larynx were planned to be treated with radical EBRT- 56 Gy and concurrent weekly chemotherapy with Cisplatin 30 mg/m2 and 5FU 400 mg/m2 placed in Group A and Group B patients were given RT with concomitant chemotherapy Cisplatin30 mg/m2, Paclitaxel 60 mg/m2 IV weekly up to 4 weeks and after a gap of two weeks all patients were given 20 Gy by reduced field without chemotherapy in both groups . RESULTS: Follow up of patient was done up to September 2008. The duration of follow up was in the range of 16-18 months. Parameters studied were local control, complication, recurrence and mortality. Nearly 79% of patients of Group B had complete response after...
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Posted by admin on Aug 1, 2010 in |
Floating matrix tablets of metformin hydrochloride were developed and evaluated for increase bioavailability by increasing gastric residence time and sustained release of drug on the upper part of gastrointestinal tract thereby diminishing side effects and enhanced patient compliance. Metformin hydrochloride, an oral antidiabetic having narrow absorption window in the upper part of gastrointestinal tract, was formulated as floating matrix tablet using gas generating agent (potassium bicarbonate) and hydrophilic gelling polymer hydroxyl propyl methyl cellulose (hypromellose) by wet granulation technique. The prepared formulations were evaluated for floating time and in vitro drug release characteristics using modified dissolution method. All formulations possessed good floating properties with total floating time more than 12 hours. Optimization study included 22 factorial design with t50% and t80% as the kinetic parameters. Matrix characterization included photomicrograph, which showed definite entrapment of the drug in the matrix. Formulations with high amount of hypromellose were found to float for longer duration and provide more sustained release of drug. The formulated drug delivery system was found to be independent...
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