Posted by admin on Aug 1, 2010 in |
Filariasis is the name for a group of tropical diseases caused by various thread-like parasitic round worms (nematodes) and their larvae. The larvae transmit the disease to humans through a mosquito bite. Filariasis is characterized by fever, chills, headache, and skin lesions in the early stages and, if untreated, can progress to include gross enlargement of the limbs and genitalia in a condition called elephantiasis. While filariasis is rarely fatal, it is the second leading cause of permanent and long-term disability in the world. The World Health Organization (WHO) has named filariasis one of only six “potentially eradicable” infectious diseases and has embarked upon a 20-year campaign to eradicate the disease. These infections have a significant economic and psychosocial impact in endemic areas, disfiguring and/or incapacitating more than 40 million individuals. Studies from the Indian subcontinent have shown that infected patients lose significant time from work because of the disease costing the national treasury a minimum of $842 million per year. The treatment of filariasis consists of using medicines that kill the worms combined with...
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Posted by admin on Jul 1, 2010 in |
The prevalence of diabetes in India has been growing by leaps and bounds. The statistics in this regard are quite alarming. It is obvious that in a country like India, the rising prevalence of diabetes with its complications is likely to produce severe constraints on health care budgets in future. This explosion of diabetes in India has been viewed with serious concern by the WHO and the International Diabetes Federation (IDF). The two principal defects in type 2 diabetes are insulin deficiency and insulin resistance. Therefore, combining an insulin-providing agent with an insulin sensitizing agent will augment the efficacy of current anti- hyperglycaemic agents. This is the rational for the development and marketing of sulfonylurea/metformin combination tablets. The ultimate or primary goal of therapy for type 2 diabetes is to prevent the mortality and morbidity related to the microvascular and macrovascular complications. Since these disorders are life long, reduction in the number of tablets and daily doses is a very important consideration from the patient point of view. It...
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Posted by admin on Jul 1, 2010 in |
Ondansetron is a serotonin 5HT3 antagonist; anti emetic drug. Bitter taste of the ondansetron is a major problem in ensuring patient compliance. Resinates of ondansetron were prepared with Indion 234 and loading process was optimized. A 3² factorial design was used for formulation development of orodispersible tablet of these taste masked resinates. The amount of subliming agent (camphor) and superdisintegrants (sodium starch glycolate) were taken as formulation variables (factors) for optimizing disintegration time, drug release after 15 minutes and friability as dependent or response variables. A mathematical model was generated for each response parameter. The disintegration time was found to linearly increase with the increase in the amount of superdisintegrants. The percentage friability showed no definite relationship with either amount of subliming agent or superdisintegrants. The optimum formulations were chosen by grid search method and their predicted results were found to be in close agreement with experimental...
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Posted by admin on Jul 1, 2010 in |
This study involves synthesis of 3- [4- aryl substituted- 3 – yl] – thiazolidin- 4 – one – 5- acetic acid by microwave oven induced synthesis method. Synthesized compounds were screened for anti-microbial activity by MIC and zone inhibition tests against various gram positive organism and gram negative organisms respectively. The microbiological assay is based upon a comparison of the inhibition of growth of micro-organism by measured concentration of the antibiotics to be examined with that produced by known concentration of a standard preparation of the antibiotic having a known...
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Posted by admin on Jul 1, 2010 in |
The present work deals with development and standardization of phytochemical screening for quantification of methanolic extract of medicinal plant stem bark of Anthocephalus cadamba (Roxb.)Miq. The scientific parameter is necessary to identify the exact plant material and to find its quality and purity. The present study deals with various, physical evaluation and preliminary phytochemical screening of various successive extracts such as qualitative chemical analysis and different spectroscopic study were carried out and the parameters were reported. HPTLC of extract shows the seven different peaks confirming that the seven compounds present in methanolic extract of Anthocephalus cadamba. The alkaloidal content of stem bark of the title plant has been determined. These studies indicated the possible information for correct identification and standardization of this plant...
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