Posted by admin on Jun 1, 2010 in |
Castor (Ricinus communis L, Euphorbiaceous) is needed in the United States to supply caster oil for the hundred of products using this versatile chemurgical raw material. 40-45 thousand tons of castor oil and derivatives are imported each year. Ricinus communis is a common medicinal plant in Ayurveda and is used several part of country for various medicinal properties like the oil of leaf and root are used against various ailments. The oil is useful for skin diseases. Castor oil seeds have tonic effect. The oil is emollient, laxative and it can be used in cases of inflammation of the intestine or dysentery. The present work attempts to summarize the Pharmacognostical characters of the Ricinus communis stem. Ash and extractive values, chemical test, HPTLC, Histological color reactions and fluorescence analysis were also carried out....
Read More
Posted by admin on Jun 1, 2010 in |
PURPOSE OF STUDY: In the present study, an attempt was made to increase therapeutic effectiveness, reduction in dosing frequency and thus improving patient compliance, by developing sustained release matrix tablets of Diclofenac sodium using guar gum as release modifier. METHOD: Six batches of sustained release matrix tablets of Diclofenac sodium was prepared by using different drug: polymer ratios viz. 1:1, 1:1.5, 1:2, 1:2.5, 1:3, and 1:3.5 for guar gum. Guar gum was used as matrix forming material, while microcrystalline cellulose as filler to maintain the tablet weight. The tablets were analyzed to determine their hardness, friability, weight variation, and an In-vitro release of drug was performed in phosphate buffer saline pH 7.4 for twenty four hours. Swelling study was also carried out to study dispersibility of gums at different concentrations. RESULTS: All the physical characters of fabricated tablets were within acceptable limits. Results show that as the concentration of gum increases, swelling index also increased proportionally. Batch G6 shows maximum drug release with sustained rate. CONCLUSIONS: It is clear...
Read More
Posted by admin on Jun 1, 2010 in |
A simple reverse phase HPLC method was developed for the determination of Esomeprazole magnesium present in bulk and pharmaceutical dosage forms. Efficient chromatographic separation was achieved on Kromasil100-C18 stationary phase (250 X 4.6 mm i.d., 5µ particle size) with simple mobile phase combination of acetonitrile: phosphate buffer 55: 45 (V/V) in an isocratic mode at a flow rate of 1.0 mLmin-1 at 301 nm. The retention time was 4.09 min (±0.5). The proposed method has been applied successfully for the analysis of Esomeprazole magnesium either in bulk or pharmaceutical dosage form with good accuracy and precision. The method herein described can be employed for quality control and routine analysis of Esomeprazole magnesium in pharmaceutical dosage...
Read More
Posted by admin on Jun 1, 2010 in |
The objective of this study was to design and develop o/w microemulsion for transdermal delivery of poorly water soluble acyclovir by aqueous titration method. Oleic acid: castor oil (3:1), tween 80, and ethanol were selected as oily phase, surfactant and cosurfactant respectively. The Pseudoternary phase diagrams were constructed by aqueous titration method. The cosurfactant affect the shape and extant of microemulsion regions. Ethanol (cosurfactant) is expected to disorder the interfacial film gave extended microemulsion zones by destabilizing the liquid crystalline phase. Largest Microemulsion single phase region was found at Smix (2:1) than the system at other Smix. Characterization of microemulsion were done for droplet Shape and size, refractive index, pH, Viscosity, drug loading capacity. The mean droplet size of microemulsion was found below 50 nm. The maximum solubility of ACV in microemulsion system was found to be 47.4 mg/ml. The ex-vivo skin permeation studies were done using skin of Wistar albino rat by Franz diffusion cell, and microemulsion formulation MEC1 exhibited highest flux, was found to be 238.1±4.87 µg/cm2/hr,...
Read More
Posted by admin on Jun 1, 2010 in |
Reaction of 1- (1- benzyl- 1H- benzo [d] imidazol- 2- yl) hydrazine (1) with 3-aryl-1-phenyl-1H-pyrazole-4-carbaldehydes (2a-f) in ethanol yielded the corresponding Schiff bases (3a-f). Further, cyclization of compounds 3a- f with thioglycollic acid in benzene in presence of anhydrous ZnCl2 furnished desired novel compounds 3- (1 – Benzyl – 1h – Benzo [D] Imidazol – 2 – L Amino) – 2 – (3 – Aryl – 1- Phenyl – 1h – Pyrazol – 4 – Yl) Thiazolidin – 4- Ones (4a- f) in 41-65% yield. All the synthesized compounds were screened for antibacterial and antifungal activities. Among the synthesized compounds 3b, 3d, 4a and 4f have shown good activity against bacteria P. aeruginosa, S. aureus and P. vulgaris, where as other compounds have shown moderate to poor activity against all the organisms. The compounds 3a and 3c exhibited good activity against fungal strains A. niger and A. flavus. All remaining synthesized compounds exhibited moderate to poor activity against all the organisms. The structures of synthesized compounds have been established...
Read More