Posted by admin on Dec 1, 2010 in |
Transdermal drug delivery system (TDDS) established itself as an integral part of novel drug delivery systems which employ a structure as a reservoir for the drugs. A number of drugs have reached the market in transdermal delivery form that has become an increasingly acceptable mode for administration of prescription and nonprescription drugs. Transdermal drug delivery system possesses many advantages over conventional modes of drug administration. Ketorolac when combined with tromethamine forms a salt (‘ketorolac tromethamine’), which has a greater aqueous solubility than ketorolac. Ketorolac tromethamine is a Nonsteroidal anti-inflammatory drug useful for short-term management of moderate to severe pain. Ketorolac tromethamine has high analgesic and anti-inflammatory potency; administered orally. The focus of this review article is to bring out different aspect related with the administration and its future impacts on human body after administration of ketorolac in transdermal drug delivery...
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Posted by admin on Dec 1, 2010 in |
The convenience of administration and improved patient compliance are important in the design of oral drug delivery system which remains the preferred route of drug delivery inspite of various disadvantages. One such problem can be solved in the novel drug delivery system by formulating “mouth dissolving tablets” (MDTs) which disintegrates or dissolves rapidly without water with in few seconds in the mouth due to the action of superdisintegrant or maximizing pore structure in the formulation. Mouth dissolving tablets are advantageous particularly for pediatric, geriatric and mentally ill patients who have difficulty in swallowing conventional tablets and capsules. The review describes the various formulation aspects, superdisintegrants employed and technologies developed for MDTs, along with various excipients, evaluation tests, marketed formulation and drugs used in this research...
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Posted by admin on Dec 1, 2010 in |
Eucalyptus is a diverse genus of flowering trees and shrubs in the myrtle family, Myrtaceae. Different chemical constituents such as Sideroxylonal C, (+)-oleuropeic acid, cypellocarpins A, B and C, cypellogins A, B and C, Leptospermone, Isoleptospermone, grandinol, various essential oils and many others have been isolated from plants of eucalyptus genus. Various eucalyptus species have been reported to possess potent pharmacological actions against diabetes, hepatotoxicity, inflammation, cancer etc. This review article is presented to compile all the updated information on phytochemical and pharmacological activities of Eucalyptus species which have been performed by widely different...
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Posted by admin on Dec 1, 2010 in |
Antibiotics have a well-documented efficacy in the treatment of established infections and as prophylactic agents in medically compromised patients. Antibiotics use is suggested to be a major risk factor for development of antibiotic resistance. Resistance to antimicrobials is emerging at an alarming rate that has reduced treatment options for nearly every pathogen infecting humans. Many bacteria now display a variety of mechanisms that help protect them during antimicrobial exposure. These include production of β-lactamases and cephalosporinases, alterations in penicillin-binding proteins, multidrug efflux pumps, transferable resistance to vancomycin, and mutations in genes encoding DNA gyrase. This article gives information about how bacteria develop antibiotic resistance, new era of antimicrobial therapeutics and new strategies to eliminate antibiotic...
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Posted by admin on Nov 1, 2010 in |
Emerging nanomedicine technologies could dramatically transform medical science as we know it today with their potential to address unmet medical needs and provide targeted therapy. Nanomedicine technologies could find an increasing place in various areas and applications of the healthcare sector including drug delivery, drug discovery and development, diagnostics and medical devices. The advent of nanomedicine and techniques for the early diagnosis of diseases could usher in a new era of superior prophylactic or preventive medicine. By using preventive medicine, treatment for diseases could be initiated even before preliminary symptoms appear. Prophylactic interventions might help postpone or even avoid diseases altogether. Nanomedicine could therefore have a huge impact on people’s lives, substantially improving their physical health and quality of life. Nanocrystal technology, for instance, is being used in drug formulation and the new chemical entities screening in the discovery phase of drug development. Quantum dot particles are being applied in high-content drug screening and in the detection of breast cancer cells among others. However, as with other new technologies,...
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