Posted by admin on Nov 1, 2010 in |
The study was undertaken to investigate the hypolipidemic and hepatoprotective effects of the different fractions (Petroleum ether, ethyl acetate and chloroform) of ethanolic extract of immature leaves of Mangifera indica. The different fractions of extract were administered intraperitonially as a single dose of 150 mg/kg body weight to alloxan induced diabetic rats and found to reduce blood lipid level (Total cholesterol and Triglycerides) significantly (p<0.05). The plant fractions also exhibited correction of altered biochemical parameters viz., SGOT and SGPT levels in diabetic rats. The effects of plant extracts were compared with standard drug metformin. The phytochemical screening tests indicated that the different constituents such as saponins, tannins, Triterpenes, alkaloids and flavonoids etc. were present in the plant which has hypolipidemic and hepatoprotective properties. Thus, this study indicates that various fractions (Petroleum ether, ethyl acetate and chloroform) of the ethanolic extract of immature leaves of Mangifera indica have favorable effect in hypolipidemic and hepatoprotective...
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Posted by admin on Nov 1, 2010 in |
Myrica esculenta (Myricaceae), commonly known as ‘Katphala’, is an evergreen, sun-temperate tree. Phytochemical constituents reported in the bark are tannins mainly epigallocatechin-3-o-gallate, gallic acid, myricanone, myricanol and a yellow dye. The edible portion of the fruit is its pulp which contains reducing sugars, tannins and vit C. Myrica esculenta (M. esculenta) is known traditionally in Ayurveda to possess various medicinal activities. In the present study antihelmintic activity of aqueous ethanolic extract of the bark of myrica esculenta was evaluated on adult Indian earthworm Pheritima posthuma, which resembles anatomically and physiologically with the intestinal round worm parasite of human being using piperazine citrate as reference standard. The extract was prepared using soxhlet apparatus and concentrated. This extract was used for the evaluation of antihelmintic activity, which caused the death of the worms at the tested dose level and it was found to be more potent than the reference control piperazine citrate. Aqueous ethanolic extract at the concentration of 12.5 mg/ml showed both paralysis and death in 20.11 & 41.25 min...
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Posted by admin on Nov 1, 2010 in |
A study was undertaken to evaluate the antioxidant potential of two species of Tinospora viz Tinospora cordifolia and Tinospora sinensis on a comparative basis. Aqueous and ethanolic extracts of both the species were subjected to in vitro antioxidant activity screening models such as DPPH, ABTS, nitric oxide and superoxide radical scavenging activity, inhibition of lipid peroxidation, reduction of ferric ions and total antioxidant capacity. Ascorbic acid was used as the standard. In all the models studied, both the plants showed nearly equal activities thereby justifying the claims of Tinospora sinensis which has not been studied extensively, and augmenting it into the present day system of...
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Posted by admin on Nov 1, 2010 in |
Methanolic extracts of the tuber of Amorphophallus paeoniifolius were investigated for its antihelmintic activity against Pheretima posthuma and Tubifex tubifex. The extract with the concentrations of 25, 50 and 100 mg/ml were tested in the bioassay, which involved determination of time of paralysis and time of death of the worms. The extract exhibited significant antihelmintic activity at highest concentration of 100 mg/ml. Piperazine citrate (10 mg/ml) was included as standard reference and distilled water as control. The extracts were found not only to paralyze (Vermifuge) but also to kill the earthworms...
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Posted by admin on Nov 1, 2010 in |
Cleome rutidosperma is traditionally used in the treatment of paralysis, epilepsy, convulsions, spasm, pain and skin disease. Extraction of the aerial parts of the plant Cleome rutidosperma using water and ethanol and evaluation of their antioxidant activity has been envisaged in this present research work. Both the extracts exhibits significant antioxidant activity in DPPH, Nitric oxide and hydroxyl radical induced In-vitro assay methods. The DPPH radical inhibition (%) was 53.13, 57.13 and 79.12 for CRA, CRE and ascorbic acid respectively. The Cleome rutidosperma extracts (CRA and CRE) showed significant free radical scavenging action against nitric oxide (NO) induced release of free radicals at the concentrations 250μg/ml, showing 29.22% and 63.32% of NO inhibition, respectively. The CRA and CRE extracts (25-400μg/ml) significantly scavenged the hydroxyl radical generated by the EDTA/H2O2 system, when compared to that of ascorbic...
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