Posted by admin on Jul 31, 2020 in |
Effective delivery of drugs can be made through various routes of administration, and the oral route is considered to be the most convenient for the administration of drugs to patients. Poor aqueous solubility was acknowledged as the main reason for the poor oral absorption of chemical entities. Apart from the conventional solubilization approaches like co-solvency, salt formation, solid dispersion, more recently self-emulsifying drug delivery systems (SEDDS) have been studied in improving the solubility and dissolution rate of poorly water-soluble and lipophilic drugs. SEDDS can be administered orally in soft or hard gelatin capsules or by converting them into tablets using different techniques like adsorption, melt granulation/extrusion and spray drying for improved stability and ease of...
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Posted by admin on Jul 31, 2020 in |
To investigate the possible protective effects of satwa from three Tinospora species against acetaminophen and alcohol-induced hepatotoxicity in rats. Male albino wistar rats were divided into six groups (n=6); healthy control, negative control (Acetaminophen 1000mg/kg b.w./day, p.o. or 30%; alcohol 1ml/100g b.w./day, p.o.), positive control (Silymarin; 100mg/kg b.w./day, p.o.), Treatment 1 (Tinospora cordifolia satwa; 200mg/kg b.w/day p.o.), Treatment 2 (Tinospora sinensis satwa; 200mg/kg b.w/day, p.o.) and Treatment 3 (Neem-giloe satwa; 200mg/kg b.w/day., p.o.). Liver injury in the rats was induced by repeated dosing of acetaminophen or alcohol for 15 days. Expression analysis of fatty acid-binding protein 1 (FABP1), peroxisome proliferator-activated receptor-gamma (PPARγ), sterolregulatory element-binding protein 1 (SREBP1), nuclear factor-kappa β (NF-κβ) and tumor necrosis factor-alpha (TNF-α) genes from liver were assayed by a semi-quantitative polymerase chain reaction. Expressions of FABP1, PPARγ were downregulated while SREBP1, NF-κβ and TNF-α were upregulated in negative control. Treatment with Neem-giloe satwa upregulated the expression of FABP1 and down-regulated the expression of NF-κβ, SREBP1, TNF-α as compared to acetaminophen treated rats. Treatment with T. sinensis...
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Posted by admin on Jul 31, 2020 in |
Solubility is the rate-limiting step for bioavailability of poorly water-soluble drugs. The solubility of poorly water-soluble drugs can be enhanced by incorporating active pharmaceutical ingredients into oral lipid-based drug delivery systems. Self micro emulsifying drug delivery system (SMEDDS) is a researcher’s choice amongst other oral lipid drug delivery systems because it offers advantages like simplicity to manufacture, convenience in scale-up, less interference of food on the dosage form and has the capability to deliver peptides. SMEDDS acts as a drug delivery carrier in which a broad range of different drug moieties can be incorporated. The bioavailability of lipophilic drugs can be significantly increased by formulating in the SMEDDS form. The present review provides a comprehensive summary for types of SMEDDS, manufacturing process, formulations aspects, evaluation characteristics, and patents registered on account of oral lipid drug delivery...
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Posted by admin on Jul 31, 2020 in |
The experiment was carried out to investigate the phytochemicals constituents of the red seaweed Hypnea flagelliformis (Greville ex J. Agardh. 1851) from Tuticorin coastal waters, Gulf of Mannar, southeast coast of India; by using HPLC, FTIR, and Gas Chromatography-Mass Spectrometry. The selected seaweed was extracted with ethyl acetate (by soxhlet extraction method), furthermore subjected to HPLC, FTIR, and GC-MS analysis to reveal the phytochemical constituents. Totally five peak values were found in HPLC analysis. Among the five, three are a prominent peak at 2.243, 2.447, and 30.787 min, and the area percentages were 23.0, 45.4, and 30.6, respectively. The IR spectrum of ethyl acetate extract shows nine peaks corresponding to the wavenumber 3403.16, 2923.88, 2853.49, 2361.67, 1717.49, 1460.98, 1378.04, 1248.82, and 1042.45 cm‑1. In the GC-MS analysis, a total of nineteen peaks were obtained, and the chromatograph showed 19 individual compounds. From all the nineteen compounds, three major compounds identified based on area percentage, which includes 1,4-eicosadiene (29.01%), n-tetracosanol-1(14.06%), and tetradecyl trichloro-acetic acid (7.90%). Further, these novel bioactive structures...
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Posted by admin on Jul 31, 2020 in |
Objective: The present study was carried out to evaluate the pharmacological evaluation of SDDCT as nephroprotective potential in rats. Material and Methods: The current study was designed to evaluate the pharmacological potential of SDDCT in Gentamicin induced nephrotoxicity in rats. The SDDCT found to be useful in suppression of nephrotoxicity. The pharmacological potential was evaluated in gentamicin 100 mg/kg induced nephrotoxicity in rats for seven days through i.p. administration, the effect of SDDCT at a different dose level that is a higher dose (100 mg/kg b.w. p.o.) and lower dose (50 mg/kg b.w. p.o.). Various physical, biochemical, and antioxidant parameters were studied. Gentamicin induced glomerular destruction, accumulation of inflammatory cells, epithelial desquamation and necrosis in parts of medulla was found to reduce in the groups receiving SDDCT along with Gentamicin. SDDCT also normalized Gentamicin induced increase in serum creatinine (0.40 ± 0.15), serum urea (30.33 ± 2.21), serum uric acid (1.80 ± 0.27) and blood urea nitrogen (16.06 ± 1.50) levels. This is also evidenced by histopathological studies. Result...
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