Posted by admin on Dec 31, 2021 in |
Gene targeting has been a promising drug delivery system, thereby helping to improve the impaired functioning in various disorders. “Lipoplexes” and “Polyplexes” incorporates lipids and polymers combined with bioactive molecules, drugs, or genes are one of the newly developing systems. The need to protect genes from degradation, allowing them to reach their target site and to promote an efficient endosomal escape, to achieve this, the delivery system has been developed. Formulation studies and clinical trials are carried out on these systems, and they are found to be very useful in the treatment of various disorders such as Cancer, Parkinsonism, Cystic Fibrosis, Rheumatoid Arthritis, Antisense Therapy, and others. The major advantage of these systems over existing liposomal delivery is that they have gene silencing activity and are highly non-immunogenic & non-viral techniques of delivering genes to the target site. Encapsulating the drug within the lipids or the polymers and targeting them at the specific site reduces the non-specific reactions. The current review article focuses on the formation, mechanism of action,...
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Posted by admin on Dec 31, 2021 in |
The aim of this study is to evaluate metformin and insulin effects on metabolic disorders and oxydatif stress markers, in Algerian men with T2D, in order to recommend the best treatment, which can minimize diabetes complications and recommend/or not a combination between metformin and insulin. Patients and Methods: We made this study on 120 subjects men divided into four groups (30 healthy control, 30 T2D without treatment, 30 T2D with metformin, and 30 T2D with insulin). Blood samples are collected for the determination of biochemical parameters (glucose, triglycerides, and cholesterol, high and low-density lipoprotein cholesterol) and oxidative markers (superoxide anion, nitric oxide, malondialdehyde, carbonyl proteins, oxygen radical absorbance capacity, vitamin C, catalase, glutathione). Results: Compared with healthy subjects, diabetic patients had altered lipid levels (cholesterol, triglycerides, LDL cholesterol) and high levels of pro-oxidant intra-cellular markers (O2•-, CP and MDA) associated to low concentrations of anti-oxidants (Vitamin C, catalase, and GSH). Our results show that insulin reduces more lipid parameters than metformin, moreover, the oxidant/antioxidant status became normal in patients...
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Posted by admin on Dec 31, 2021 in |
For the last few centuries, the leaves of Stevia rebaudiana have been used as an efficient substitute for sugar due to its sweetness and almost negligible Glycemic effects. The study concentrates on the pharmacognostic aspects and other anatomical characteristics of the leaves. The study is performed on the plant leaves collected from the medicinal plant garden of Birla Institute of Technology, Mesra, Ranchi, India. The study is purely concentrated on finding various morphological characteristics and microscopic characteristics of the leaves. The microscopic characterization includes understanding the various anatomical characters of the leaves as well as the identification of the various diagnostic characteristics related to the leaves. Leaf constants, such as the Stomatal index, Stomatal number, Palisade ratio, vein-islet, and vein termination numbers, were also determined. The study also aims to determine various physicochemical parameters such as Moisture content, total ash, and extractive values. Preliminary phytochemical characterization of the aqueous extract of the leaves was also...
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Posted by admin on Dec 31, 2021 in |
Background: Cardiometabolic syndromes are the co-occurrence of metabolic abnormalities such as obesity, insulin resistance, atherogenic dyslipidemia, and hypertension. Cardiometabolic disorders includes type2 diabetes mellitus, metabolic syndrome, and cardiovascular diseases. The prevalence of cardiometabolic disorders are growing in epidemic proportions all over the world; hence cardiometabolic disorders are a major health problem in developing as well as in developed countries. It has been observed in the previously reported clinical studies that deficiency of vitamin D is a highly prevalent risk factor in the patients with cardiometabolic disorders and it has been suggested that deficiency of vitamin D has a crucial role in the pathogenesis of cardiometabolic disorders. Aim: To reveal the role of vitamin D deficiency in cardiometabolic disorders and the opportunity of vitamin D supplementation as vital therapy in cardiometabolic disorders. Methods: We performed a systematic review based on available literature of vitamin D deficiency in cardiometabolic disorders using PubMed, Google Scholar, Science Direct, and Willey online library databases up to November 2020. Conclusion: Vitamin D deficiency has a...
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Posted by admin on Dec 31, 2021 in |
Chronotherapeutic systems are meant for the treatment of most of the diseases that occurred and found till date, which are proved to be in association with the biological/circadian rhythms of our body with respect to disease symptoms and their severity. Such diseases use this treatment as it involves in-vivo drug availability with distinctive release patterns so as to match the rhythms of disease and achieve optimized therapeutic outcomes with minimized side effects. The specific time at which patients take their medications is taken into consideration as it is the main reason for the treatment success. There is a synchronization of pharmacodynamics and pharmacologic activity of drugs with that of the biological clock, so variations in disease state and plasma drug concentration are taken into consideration during the development of this drug delivery system. Various novel technologies are employed in developing Chronotherapeutic devices and dosage forms, some are available in the market already, and many others are yet to arrive. The main objective of this review is to explore the...
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