Posted by admin on Dec 31, 2024 in |
Rosmarinic acid, a key component of Rosemary (Rosmarinus officinalis), holds significant promise as an adaptogen in herbal medicine, offering a natural remedy to counteract stress’s wide-ranging impacts on health. This abstract explores rosmarinic acid’s pharmacological activities, emphasizing its modulation of the hypothalamic-pituitary-adrenal (HPA) axis, regulation of neurotransmitters, antioxidant and anti-inflammatory effects, and enhancement of mitochondrial function. Integrating insights from traditional medicine like Ayurveda and Traditional Chinese Medicine (TCM), alongside modern scientific validation, highlights Rosemary’s evolution from culinary herb to medicinal powerhouse. Structurally, rosmarinic acid’s stability, facilitated by its ester-bonded dual phenolic rings, supports its therapeutic efficacy. Experimental studies underscore its ability to reduce cortisol levels, bolster stress resilience, stabilize mood, and enhance cognitive function by influencing neurotransmitter systems. Moreover, its robust antioxidant and anti-inflammatory properties, validated across in vitro, animal models, and clinical trials, suggest potential applications in preventing oxidative stress and inflammation-linked diseases. By promoting mitochondrial biogenesis and activating the AMPK pathway, rosmarinic acid enhances cellular energy production, further fortifying resilience to stressors. In summary, rosmarinic acid emerges...
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Posted by admin on Dec 31, 2024 in |
Hyperpigmentation is a skin complaint where black patches or spots appear on skin. It affects a large percentage of the human population. Cosmetics that naturally lighten the skin have been shown to be both safe and effective for treating hyperpigmentation. To achieve a lighter skin appearance, skin lightening goods are commercially accessible for cosmetic resolutions. They’re also utilised in the clinic to treat pigmentary disorders like melasma and post-inflammatory hyperpigmentation. Various stages of melanin content in the skin are affected by whitening agents. The finding demonstrates that numerous bioactive substances have anti-oxidant and anti-inflammatory properties in addition to tyrosinase inhibition, melanosome transfer inhibition, and other mechanisms that affect the melanin production pathway. Many of them have been identified as good inhibitors of tyrosinase, a central enzyme in the process of melanogenesis. Others stop this enzyme from maturing or from transporting pigment granules (melanosomes) from melanocytes to keratinocytes. We present an overview of whitening products obtained from natural sources that may reduce skin pigmentation by interfering with pigmentary processes in...
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Posted by admin on Dec 31, 2024 in |
Introduction: The goal of BTS (Blood Transfusion Service) is to provide safe and quality blood and blood products to needy patients. In developing and underdeveloped countries, there exists a gap between the demands and supply of blood products. Since 100% voluntary blood donation is not achieved, we rely on replacement donors also. Hence this study was attempted to assess the seroprevalence of TTI (transfusion-transmitted infection) in blood donors and to compare the seroreactivity rate between voluntary and replacement donors. Materials and Methods: This retrospective study was done on the blood donors over the period of 4 years from January 2020 to December 2023 in a tertiary care hospital. Donor samples were screened for the five mandatory TTIs, viz., HIV (human immunodeficiency virus), HBV (hepatitis B virus), HCV (hepatitis C virus), syphilis, and malaria. Results: A declining trend in HBV was evident from 2020 to 2023. Prevalence of syphilis was highest in 2022. No marked change noted with HIV and HCV. The TTI rate in non-remunerated voluntary blood donors (NRVBD)...
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Posted by admin on Dec 31, 2024 in |
The aim of this paper is to give a systematic overview on the morphology, ethnobotanical uses, phytochemistry and pharmacological activities of Anogeissus latifolia. It focuses to identify the research gap and further proceed to experimental studies. It may also help out the researcher for further detailed studies. A systematic search criterion of literature was carried out by computing Google scholar, Pub med, NCBI, open access peer reviewed journals and web of science including some unpublished sources. The plant is known to possess wide range of pharmacological activities like Anthelmintic, Thrombolytic, Antiasthmatic, Anticonvulsant, Anticancer, Antidiabetic, Antibacterial, Antipyretic, Antioxidant, Antiulcer, Analgesic, Anti-inflammatory, Hepatoprotective and Wound healing activity. Limited numbers of phytoconstituents were reported like tannins, triterpenoids, ellagic acid, monosaccharides, β- sitosterol from the plant that shows biological activities with diverse ethnobotanical uses. The present review also explores the traditional medicinal uses of the tree, highlighting its role in treating various ailments and wide use of its gum in pharmaceuticals, food processing and...
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Posted by admin on Dec 31, 2024 in |
Grafting polymerization is a process in which polymer chains are covalently bonded (grafted) onto a backbone polymer, leading to the formation of a new material with enhanced properties or functionalities. This process involves the attachment of polymer chains (known as “graft chains” or “grafts”) onto the surface or within the bulk of the substrate material. Polysaccharides have numerous applications in various industries, including food, pharmaceuticals, cosmetics, and biotechnology. They are used as thickeners, stabilizers, emulsifiers, gelling agents, and drug delivery systems due to their biocompatibility, biodegradability, and functional properties. Flavonoids are a group of polyphenolic secondary metabolites found in plants, fruits, and vegetables. They show a wide range of health benefits. They have gained interest recently due to their possible benefits for human health, especially their antioxidant, antiviral, antiallergic, anti-inflammatory, and anticancer characteristics. Flavonoid-grafted polysaccharide-form complexes generate synergistic effects, such as enhanced physical, chemical, and functional properties. Therefore, they show great potential for applications in food, cosmetics, and medicine. Structural characterization methods of the graft products, including FTIR, NMR,...
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