Posted by admin on Jul 31, 2025 in |
Patients with diagnosed BPH, suffer very frequently from lower urinary tract symptoms (LUTS). It is very crucial to find the types, prevalence, and impact of LUTS in association with age, glycaemic index, and modifiable risk factors for developing targeted management strategies. The research seeks to determine types of LUTS present in BPH patients across various age groups and their impact on QoL; and impact of glycaemic levels, as well as the sociodemographic factors like smoking and alcohol use on the severity of the LUTS/BPH. This is a prospective observational study conducted from September 2023 to February 2024 at Narayana Medical College and Hospital of Nellore district, Andhra Pradesh. 200 male patients above 45 years old with LUTS/BPH were selected by the random sampling technique. Data was collected using an IPSS questionnaire, and therefore analysed using qualitative and quantitative approaches, as well as multiple regression analysis and ANOVA. This study captures the multifactorial impacts of LUTS in BPH patients and underscores the importance of addressing modifiable risk factors and co-existing...
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Posted by admin on Jul 31, 2025 in |
Kinetics of oxidation of L-cysteine and DL- Methionine by potassium permanganate in alkaline medium was studied spectro-photometrically at room temperatue. The reaction was found to be of first order with respect to amino acid, zero order with respect to oxidant and fractional order dependence on Alkali. It was found that the rate of the reaction increases with increase in concentration of [OH-]. There is a good agreement between observed and calculated rate constant under experimental conditions. The activation parameters are computed with respect to the slow step of the reaction. Cysteine exhibits relatively consistent kinetic behavior than Methionine. The oxidation product of the reaction was found to be cysteine and Methionine sulfoxide. A plausible reaction mechanism has been proposed for the experimental...
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Posted by admin on Jun 30, 2025 in |
Background: Cognitive impairment is a serious problem, especially for the elderly. Cognitive impairment is often associated with neurological disorders and congenital diseases. The impact of central nervous system depressants (CNSDs) on cognition needs to be further investigated. Objective: This study aims to evaluate the relationship between CNSD use and cognitive impairment with neurological disorders and comorbidities, along with the severity of cognitive dysfunction. Materials and Methods: A prospective cross-sectional study was conducted over a 6-month period in a tertiary care hospital, including 129 patients aged 18 years and older. Cognitive function was assessed using a structured questionnaire and severity scales. Data on demographics, neurological disorders, medications, and comorbidities were collected from patient records and statistically analyzed. Results: Cognitive decline increased with age, particularly in patients aged 61+ years. Benzodiazepines were significantly associated with mild cognitive impairment. (22%, p = 0.02), while anti-convulsant and anti-Parkinsonian drugs had minimal impact. Stroke patients with comorbidities showed the highest rates of cognitive decline (25.3%, p = 0.01). Conclusion: The Results indicate that while...
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Posted by admin on Jun 30, 2025 in |
Circadian clock is an impressive timing system responsible for the control of several metabolic, physiological and behavioral processes. Chronotherapeutic is an approach that aligns the timing of drug delivery with the rhythms of diseases or disorders to optimize therapeutic responses and minimize side effects. This method ensures the purposeful and controlled release of medications in varying amounts over a 24-hour period. Chronotherapeutic drug delivery systems are becoming increasingly important in pharmaceutical technology, as they reduce dosing frequency and toxicity while delivering drugs in sync with the circadian rhythm (CR) of specific diseases, ensuring optimal treatment when symptoms are at their peak. Eventually, the benefit goes to the patient due the compliance and convenience of the dosage form. Chronotherapy is the conveying drugs in the body at the target site by maintaining perfect synchronicity with circadian rhythms. Chronotherapy refers to the use of circadian, ultradian, in radian& seasonal or other rhythmic cycles in the application of therapy. Some of the conditions, which may be significantly benefited, are hypertension, myocardial infarction,...
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Posted by admin on Jun 30, 2025 in |
Hydrogels are three-dimensional polymeric network structures having high water content. Stimuli-responsive or smart polymers are macromolecules that show a significant physiochemical change in response to small changes in their environment. These smart hydrogels with chemical and structurally responsive moieties show excellent characteristics of reacting under different environmental conditions such as temperature, pH, light, magnetic field, ionic factors, etc. These polymers have the ability to observe a change (stimulus) in their environment, respond to it immediately, and then return to their original shape/state when the stimulus is removed. Due to the high-water content of hydrogels and more similarity with biological tissues, hydrogels provide an ideal environment for cell survival, and structure which mimics the biological tissues. More water content, soft consistency and low interfacial tension with biological fluids makes them biocompatible. Due to their superior biocompatibility and low toxicity hydrogels have a significant role in the biomedical fields. In biomedical field, these super intelligent hydrogels have gained a significant interest in tissue engineering, drug delivery, diagnostics, imaging and optics. The...
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