Posted by admin on Jul 31, 2025 in |
A topical drug delivery system involves applying medication to the skin for therapeutic effects or to treat skin disorders. Traditional gels often struggle to deliver hydrophobic drugs effectively, a challenge that can be overcome with emulgels. Emulgels, which combine emulsions and gels, create a dual-release control system that enhances medication efficacy. This innovation is essential in topical delivery systems, significantly improving bioavailability and patient compliance. Emulgel are widely utilized in numerous cosmetic products and for medical applications such as analgesic, antifungals, anti- inflammatory and anti-acne therapies. These topical administration systems have the major benefit of being able to avoid first-pass metabolism, which increases the active compounds’ bioavailability. Emulgels are non-greasy, thixotropic, and easily spreadable, having beneficial qualities for dermatological uses. They also have a longer shelf life because they are water-soluble, emollient and simple to remove. Emulgels are a noteworthy advancement in the field of topical drug administration because of their translucent and visually pleasant look, which also improve user experience. It is a very productive area of research...
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Posted by admin on Jul 31, 2025 in |
The aim of this study is to assess the antibacterial efficacy of the Datura stramonium seeds and leaves extracts against Mycobacterium kansasii. The antimicrobial experiments were performed using five doses (0.25µg/ml, 0.50µg/ml, 1µg/ml, 2µg/ml, 4µg/ml) of seeds and leaves extracts. The results showed notable inhibitory effects on Mycobacterium kansasii. The results indicated that the extract of D. stramonium exhibited action against all the tested bacterial isolates, with the level of activity varying depending upon the concentration. The hexane extract of seeds DSS-1H exhibited antibacterial activity, with mean zones of inhibition measuring 98.94±50.25.%, 120.98±56.92%, 120.499±69.60%, 125.752±133.18% and 89.494±180.63%, at the doses of 0.25, 0.50, 1, 2, and 4 µg/ml and while treating with DSS-2A the percent cell viability of the microbial cell was found to be 128.02±25.64%, 86.79±14.95%, 34.61±16.33%, 26.29±29.76% and 32.56±19.48% at the doses of 0.25, 0.50, 1, 2 and 4µg/ml, respectively, with incubation period of 48 hours. Similarly, the microbial cells were treated (0.25, 0.50,1,2,4 µg/ml) with DSS-3ET with incubation period of 48 hours, indicating a more substantial...
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Posted by admin on Jul 31, 2025 in |
Aquasomes are a highly advanced nanoparticulate transport system in nanotechnology. It is mostly utilized for medication delivery. These carriers are differentiated by their three-layered structure, which includes a solid nanocrystalline core (often calcium phosphate or ceramic diamond), a polyhydroxyoligomeric film, and functional properties. The core is solid mechanical strength and stability, but the carbohydrate covering protects the bioactive compounds from dehydration and denaturation. Aquasomes are typically ranging from 60 to 300nm, making them appropriate for a variety of biomedical applications. One of the key benefits of aquasomes in their capacity to deliver medicines, proteins, peptides and genes to particular locations in the body with high precision. This tailored delivery technology increases medicinal efficacy while minimizing negative effects. Additionally, aquasomes provides delayed and prolonged release of the encapsulated compounds, which improves overall treatment outcomes. Aquasomes have demonstrated great potential for delivering insulin, vaccinations and other medicinal substances. Their biocompatibility and capacity to maintain the stability of sensitive molecules make them an adaptable tool in creation of improved drug delivery...
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Posted by admin on Jul 31, 2025 in |
Background: Capsaicin, a bioactive compound derived from the dried fruit of the Solanaceae family, is widely recognized for its therapeutic potential. Its mechanism of action involves interaction with TRPV1 receptors, leading to analgesic effects and modulation of neurogenic inflammation. Objective: This review explores the therapeutic applications of capsaicin, particularly its role in treating non-allergic rhinitis, neuropathic pain, and inflammatory conditions. It also highlights its potential in preventing pneumonia and cluster headaches. Methods: A comprehensive review of existing clinical studies and randomized controlled trials (RCTs) observational studies, and systematic reviews, Randomised placebo- controlled, double blind study, Clinical case series with pre-post outcome assessment was conducted to evaluate capsaicin’s efficacy, and mechanisms of action. Special emphasis was placed on intranasal formulations and their impact on nasal sensory nerve Fibers. Results: Capsaicin has demonstrated significant benefits in reducing nasal symptoms, improving nasal airflow, and alleviating neuropathic pain. Repeated nasal applications have been shown to provide prolonged relief for idiopathic rhinitis, while intranasal capsaicin has been effective in cluster headache prevention. Studies indicate...
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Posted by admin on Jul 31, 2025 in |
A sensitive, specific and precise HPTLC method for simultaneous estimation of Fenofibrate and Rosuvastatin has been developed and validated. The method employed aluminium plates pre-coated with silica gel 60 F254 as the stationary phase. The solvent system consisted of n-Hexane: Acetone: Ethyl acetate: Glacial acetic acid (4: 5: 0.9: 0.1, v/v/v/v) which was found to give compact and dense spots for Fenofibrate and Rosuvastatin (RF value 0.83 ± 0.05 and 0.35 ± 0.05 respectively). Densitometric analysis of both drugs was carried out at 300 nm. Linear relationship was found with calibration curve for linearity in concentration range of 25-75 mg/spot and 167-501 mg/spot for Rosuvastatin and Fenofibrate with Correlation coefficient value 0.992 and 0.991 respectively. This method was found to be good percentage recovery for Rosuvastatin and Fenofibrate in between 98% to 102%. All parameters of validation of the formulations were found within the limit as per ICH...
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