Posted by admin on Jul 31, 2025 in |
Introduction: The use of traditional herbal medicines in conjunction with modern pharmaceuticals is a growing trend. However, the concurrent use of these therapies can lead to significant pharmacological interactions affecting drug metabolism, efficacy and safety. Objective: This systematic review aims to provide a comprehensive overview of pharmacological interactions between traditional herbal medicines and modern pharmaceuticals, highlighting common interactions, elucidating underlying mechanisms and offering clinical recommendations. Methods: A systematic search was conducted in databases including PubMed, MEDLINE and the Cochrane Library for studies published up to July 2024. The review included clinical trials, observational studies, and reviews that examined interactions between herbal medicines and pharmaceuticals. Data were extracted and assessed for quality using the Cochrane risk-of-bias tool and the Newcastle-Ottawa Scale. Results: Out of 3,245 records identified, 50 studies were included in the qualitative synthesis and 20 studies were included in the quantitative synthesis. Common herb-drug interactions were identified, such as St. John’s Wort with antidepressants and anticoagulants, Ginkgo Biloba with anticoagulants and anticonvulsants, and Ginseng with antidiabetic drugs and...
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Posted by admin on Jul 31, 2025 in |
The use of topical drug delivery systems is becoming increasingly popular due to their convenience and effectiveness. However, the potential of proniosomal gel for delivering econazole nitrate topically has not been widely studied. This study focuses on designing and optimizing a proniosomal gel formulation of econazole nitrate to improve antifungal therapy. The proniosomal gel was prepared using the coacervation phase separation method, incorporating Span 60, cholesterol, and other ingredients. The ratio of non-ionic surfactants to cholesterol significantly affects drug entrapment efficiency and release characteristics. The formulated proniosomes were evaluated for parameters such as entrapment efficiency, vesicle size, and in vitro drug release. Optimization using a central composite design examined the impact of varying Span 60 and cholesterol ratios on these properties. The optimized formulation showed a sustained drug release of 12 hours and a high entrapment efficiency of 95.41% at an optimal Span 60-to-cholesterol ratio of 6.65:1. The vesicles were found to be discrete and spherical. Additionally, the optimized formulation demonstrated superior antifungal activity, showing a larger zone of...
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Posted by admin on Jul 31, 2025 in |
Green Nanotechnology techniques have emerged in response to the growing need for sustainable and eco-friendly approaches to synthesize nanoparticles. The present study provides an endurable procedure for the green-mediated synthesis of silver nanoparticles (AgNPs) from Albizia amara leaf extract and its antibacterial potential. Various techniques like UV-Vis spectroscopy, FT-IR, XRD and FE-SEM were employed to characterize the properties of the silver nanoparticles. The UV-Vis spectra exhibited a maximum peak for AgNPs at 425nm, confirming their absorption capability. The presence of OH and COOH functional groups was evident from the FT-IR analysis which contributes to the stability of nanoparticles. The XRD patterns displayed distinct diffraction peaks. The morphology of AgNPs was determined by FE-SEM and the elemental composition of synthesized nanoparticles was exhibited in EDS mapping. When the silver nanoparticle was tested against the clinical pathogens, the results demonstrated a considerable inhibition of bacterial growth. The magnitude of the zone of inhibition exhibited by silver nanoparticles showed high antibacterial activity with zones measuring 19mm against Enterococcus faecalis strain. The results...
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Posted by admin on Jul 31, 2025 in |
In the search for novel anticancer drugs, coumarin derived chalcones were analysed using in-silico tools like chemdraw, chemsketch, molinspiration, CASTp, Argus lab etc. Epidermal growth factor receptor protein is involved in cell signaling pathways that control cell division and survival. Molecular docking studies of test compounds with the EGFR tyrosine kinase domain (PDB ID: 6LUD) protein provided the significant docking scores for each test compound (-8.38163 to -11.2691 kcal/mol). In this study, we synthesized and evaluated a novel anticancer compound using MTT assay which measures cell viability by detecting mitochondrial activity. Compound 3M was synthesized through condensation of 6 -acetyl-7-hydroxy-4-methylcoumarin with aromatic aldehyde. The purity was done by recrystallization and structure of compound 3M were confirmed via IR spectroscopy, which provided detailed information on functional groups and structural features. Results demonstrated that 3M exhibited significant cytotoxicity against MCF-7 cell line indicating its potential as a therapeutic agent with a significant inhibition of cell growth with an LC50 value of 68.1549µg/mL. The compound’s efficacy was assessed using a series of...
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Posted by admin on Jul 31, 2025 in |
Alzheimer’s Disease is considered as the most common form of dementia, contributing to about 70% of the cases. The FDA approved Acetyl cholinesterase inhibitors and NMDA receptor antagonists only produce a symptomatic relief and raises the need for novel potential drug candidates for AD management. The various hypotheses on Alzheimer’s Disease reveal its multifactorial nature and thus these multiple targets can be considered for the development of new drug molecules. In this study we focus on designing new carbamate- heterocycle molecules with different heterocycles indole, isoquinoline, thiazole, oxazole and 1,2,4- triazines and identifying their multitarget potential through computer aided drug design. The proposed conjugates were docked with the targets Acetyl cholinesterase (AChE), N-methyl- D- Aspartate Receptor (NMDA), and Tyrosinase enzyme. The results indicated that the compound ISO-10 exhibits a high binding affinity for three targets. The target 1FSS demonstrated the highest binding affinity of the three and is suitable for molecular...
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