Posted by admin on Dec 31, 2024 in |
Despite being hard to define, stem cells have a lot of potential as therapeutic agents and as tools for understanding development. Like any new field, though, blind excitement can sometimes eclipse reality. Nine widespread misunderstandings that we feel have an impact on how we assess stem cells as therapeutic possibilities are outlined in this review. We propose that each of these factors should be carefully observed and taken into account when assessing a specific cell for use in therapy. The unquestionable promise of stem cell biology must be assessed using rigorous scientific techniques, and data from both positive and negative trials must be gathered and presented. Stem cell treatments are at show demonstrated for a run of clinical conditions past conventional beginnings to treat hereditary blood illnesses and have seen considerable victory. In this respect, developing utilize for stem cells is their potential to treat torment states and neurodegenerative infections such as Parkinson’s and Alzheimer’s malady. Stem cells offer trust in neurodegeneration to supplant neurons harmed amid certain infection...
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Posted by admin on Dec 31, 2024 in |
Alcohol-related liver diseases and their associated damage pose significant health concerns globally. Among potential remedies, esculetin, a saturated dicarboxylic acid known for its anti-inflammatory and antioxidant attributes, stands out. This study aims to explore the hepatoprotective effects of esculetin in rat models afflicted by liver damage induced by ethanol+ lipopolysaccharide (LPS). To emulate alcoholic liver damage, adult Wistar rats were subjected to 10 days of ethanol (5 mL/kg b.w) and a single dose of LPS (5 mL/kg b.w) orally on the 11th day. Esculetin was administered orally to rats for the same 11 days duration, at doses of 50 mg/kg b.w, with a one-hour interval before inducer administration. The results revealed a remarkable reduction in the elevated levels of serum enzymes AST, ALT, ALP, and GGT following esculetin treatment, effectively restoring them to normal levels. Moreover, esculetin exhibited a substantial decrease in liver lipid peroxidation levels compared to the ethanol and ethanol+LPS group, indicating its potent management of severe oxidative stress. The addition of esculetin to the ethanol and...
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Posted by admin on Dec 31, 2024 in |
Traditional herbal remedies predate all other medicinal systems for thousands of years. The physicochemical and phytochemical analysis of Impatiens balsamina flowers reveals valuable insights into its composition, emphasizing its potential in herbal medicine and food science. The total ash content was 7.45 g/100 g, with significant portions of acid-insoluble (2.67 g/100 g) and water-soluble ash (3.28 g/100 g), indicating mineral richness. The extract was more soluble in water (18.32 g/100 g) than in alcohol (12.45 g/100 g), suggesting the predominance of water-soluble bioactive compounds. The low moisture content (8.67 g/100 g) ensures good storage stability. Organoleptic analysis highlighted its pale pink color, soft texture, astringent taste, and floral aroma. Phytochemical screening confirmed the presence of essential bioactive compounds such as flavonoids, alkaloids, terpenoids, phenols, and saponins across various solvent extracts. These results underscore the therapeutic and nutritional potential of Impatiens balsamina flowers for diverse applications in pharmaceuticals, nutraceuticals, and...
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Posted by admin on Dec 31, 2024 in |
The co-occurrence of Type 2 Diabetes Mellitus (T2DM) and hypertension is a growing public health concern in India. Effective management requires careful consideration of prescribing indicators, pharmacoeconomic implications, and therapeutic adherence. This review aims to explore the current landscape of prescribing practices, economic burden, and adherence patterns among Indian patients suffering from both T2DM and hypertension. A thorough understanding of these factors can guide policymakers, healthcare professionals, and researchers toward more efficient and cost-effective treatment...
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Posted by admin on Dec 31, 2024 in |
Medicinal plants are presently viewed as being of great value because of their unique qualities as a significant source of medicinal phytochemicals that might result in the creation of new medications. Oldenlandia pumila (L.f.) DC. belong to Rubiaceae family and found as a weed throughout India. Oldenlandia pumila (L.f.) DC. has antibacterial, antiviral, antioxidant, anticancer, anti-inflammatory, and antiplasmodial activities. The effects of three different solvents were investigated in the current study to determine the presence of phytochemicals, total phenolic content, total flavonoid content, and antioxidant assay. The preliminary phytochemical analysis revealed the presence of carbohydrates, flavonoids, tannins, and alkaloids whereas finding the absence of proteins and glycosides in the various extracts. Phytochemical analysis showed that Oldenlandia pumila (L.f.) DC. contained TPC ranging from (82.235 ± 0.005 mg to 424 ± 0.005 mg GAE /g) while TFC ranging from (38 ± 0.006 mg to 336 ± 0.006 mg GAE /g). The TAC ranges from (18.285 ± 0.007 to 89 ± 0.006 mg AE/g) and the TAC ranging from (64.8 ±...
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