Posted by admin on Nov 1, 2013 in |
Arterial thrombus formation are due to mainly platelet activation and aggregation which are considered to be central to pathological changes occurring in the vessel leading to the various complications and mortality . Antiplatelet drugs are used to prevent and help in the reversal of platelet aggregation in arterial thrombosis which was the major culprit in the pathology of myocardial infarction and ischaemic stroke. The most widely used antiplatelet agent namely Aspirin inhibits platelet cyclo-oxygenase which helps in conversion of arachidonic acid to platelet agonist thromboxane A2 but does not prevent platelet activation occurring via various signalling pathways that are independent of thromboxane A2 release. So apart from aspirin, a number of other compounds have been developed to overcome the deficiency by aspirin. Another major concern regarding the antiplatelet theraphy was the resistance by these drugs in preventing the troublesome complications. Bleeding is the most dreadful complication of most of the antiplatelet drugs. In general, in clinical practice, antiplatelet theraphy is instituted in patients whose thrombotic risk clearly overweighs their...
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Posted by admin on Nov 1, 2013 in |
Fungal infections in critically ill or immunosuppressed patients were increasing in incidence in the human population over the last 1-2 decades. There were few advances in antifungal therapy and, until recently, there were few choices from which to select a treatment for systemic mycoses. However, in the past decade, there have been several developments in this area. Antifungal agents are sufficiently diverse in activity, toxicity, and drug interaction potential. Azoles are synthetic and semi-synthetic compounds. They have a broad spectrum of activity. Triazole antifungals are active to treat an array of fungal pathogens, whereas imidazoles are used almost exclusively in the treatment of superficial mycoses and vaginal candidiasis. Despite the advances, serious fungal infections remain difficult to treat, and resistance to the available drugs is emerging. Use of the currently available azoles in combination with other antifungal agents with different mechanisms of action is likely to provide enhanced efficacy.The present review aims to explore the pharmacology, pharmacokinetics, spectrum of activity, safety, toxicity and potential for drug–drug interactions of the...
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Posted by admin on Nov 1, 2013 in |
Aim: The aim of the present study was to evaluate lead toxicity on the male reproductive system during developing period of neonates. Methods: Histopathological alterations were observed in testis of neonates on PND 1 and PND 21. Lead acetate was administered via oral gavaging at 320 mg/kg BW to pregnant Swiss mice from 10th day of gestation upto 21st day of lactation. OralExposure of 160 mg/kg BW vitamin C (ascorbic acid) and 130 mg/kg BW vitamin E (tocopherol acetate) was given from 10th day of gestation upto 21st day of lactation. Result: Oral supplementation of antioxidants vitamin C and E with lead slightly recovered these adverse effects and retained normal function but independently they also induced obstruction in development of testis. Conclusion: We can conclude from our findings that lead acetate administrated during gestation and lactation adversely affects developing testis. Supplementation of high doses of vitamins during gestation and lactation are not beneficial because they also generate some alterations in developing...
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Posted by admin on Nov 1, 2013 in |
A Simple, Rapid, Precise, Accurate, Robust and Stability indicating Reverse Phase HPLC method has been developed to estimate Capecitabine in tablet dosage form using mobile phase mixture consisting of Phosphate buffer : Acetonitrile (80:20) v/v at the flow rate of 1.2ml/min. The Hypersil BDS C8 column (250mm x 4.6mm x 5mm) was used as the stationary phase. The mobile phase was run for 15 min at the wavelength of 240 nm. The mean recovery was found to be 99.91%. The linearity range was 50% to 150% and was found to be successful under 0.999. The proposed method has fulfilled all the validation parameters such as linearity, Robustness, Accuracy, System Precision, intermediate precision, method precision, solution...
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Posted by admin on Nov 1, 2013 in |
Gold nanoparticles (AuNPs) have appeared as an attractive candidate for delivery of various drug molecules or considered as extraordinary molecular carriers for the targeting, intracellular trafficking and delivery of a huge array of biomolecules including DNA, RNA, proteins, peptides, drugs, genes and other molecules of therapeutic significance. Particularly gold nanoparticles have attracted intensive interest, because they are easily prepared, have low toxicity and can be readily attached to molecules of biological interest. More and more research shows that AuNPs-based technologies are becoming promising approaches in drug and gene delivery, liver targeting, brain targeting, cancer research and AIDS treatment. The present review focuses on synthesis and functionalization methods of GNPs, the past researchs and reviews about GNPs, their emerging applications and uses and their future...
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