Posted by admin on Jun 1, 2013 in |
From this article, we get the knowledge about the transdermal patch, transdermal drug delivery system and anatomy of the skin. Now-a-days transdermal drug delivery, system is widely used in much disease. So, this article gives the knowledge about pre transdermal system, post transdermal drug delivery system and future of transdermal drug delivery systems and examines the benefits and limitations of current transdermal drug delivery system. We also get information about different drugs’ transdermal patch which was approved by FDA in different years. There is a difference in design of transdermal patch in which mainly design of liquid reservoir system and adhesive matrix system and system how it works. Here in first generation, mainly reservoir system is used, while in second generation mainly iontophoresis and chemical penetration enhancers can be used however in third generation thermal ablation as a penetration enhancer can be used. These all designs include in different generation which shows what is the novel approach occurs as the time gone. So, these guide to basic and modified...
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Posted by admin on Jun 1, 2013 in |
Two simple, rapid, precise and accurate spectrophotometric methods have been developed for simultaneous estimation of Diclofenac Sodium (DIC) and Esomeprazole Magnesium Trihydrate in bulk drugs and synthetic mixture. Method A, Simultaneous equation method (Vierodt’s method) applies measurement of absorptivities at two wavelengths, 280.00 nm, (λmax of Diclofenac Sodium) and 301.00 nm,( (λmax of Esomeprazole Magnesium Trihydrate) in zero order spectra. The concentrations can be calculated from the derived equations. Method B, Absorbance ratio method (Q-method) involves formation of Q-absorbance equation at 302.80 nm (isoabsorptive point) and 280.00 nm (λmax of Diclofenac Sodium) in zero order spectra. Developed methods were validated according to ICH guidelines. The calibration graph follows Beer’s law in the range of 2.0 to 10.0 μg/ml for Esomerazole Magnesium Trihydrate and 5.0 to 25.0 μg/ml for Diclofenac Sodium with R2 value greater than 0.999. Accuracy of all methods was determined by recovery studies and showed % recovery between 98 to 102%. Intraday and inter day precision was checked for both methods and mean %RSD was found to...
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Posted by admin on Jun 1, 2013 in |
A research was conducted to design a directly compressible filler binder characterized with rapid release and mouth disintegrating. Acacia gum was obtained from local source and was purified using a standard method. Tapioca starch was also extracted from cassava tuber using a standard method. Both primary excipients were evaluated for power properties and coprocessed at varying concentration using mixture of isopropranol and water at ratio 2:1. The various coprocessed placebo composite filler-binders (TSAG) were evaluated for granules and tablets properties. The composite containing 85 % tapioca starch and 15 % acacia gum (TSAG-15) have excellent flow rate, angle of repose, compressibility index and Hausner’s ratio: 25 g/s, 30o, 17.3 %, and 1.2 respective. The placebo tablets of this composite was characterized with high functionality, when compressed at 6.5 KN, gave crushing strength of 102 N, friability of 1.12 %, disintegration time of 5-6 min. Ascorbic acid tablets compacted with the composite filler binder having 80 % TSAG-15 and 20 % ascorbic acid gave good compacts with average crushing strength...
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Posted by admin on Jun 1, 2013 in |
Background: β2- agonist drugs are frequently prescribed in asthmatics. Apart from bronchodilation they affect biochemical and physical parameters of the body. Method: Total 80 patients were divided into two groups. Group I (n=40) received Albuterol- 2.5mg./2.5ml. TDS and Group II (n=40) received Levalbuterol- 0.63mg./2.5ml, TDS via nebulizer for 4 weeks. Baseline and post-treatment estimation of biochemical parameters including, fasting and postprandial plasma glucose levels, serum Na+, serum K+ levels, lipid profile, Monitoring of systolic and diastolic BP and adverse drug effects evaluation were carried out. Results: Significantly changes were in serum lipid profile and blood glucose in both the groups but increase was more in group I. Serum K+ level was decreased significantly (p<0.05) in both groups but decrease was more in group I patients. The fasting and postprandial plasma glucose levels were significantly increased in both the groups but increase was more in group I. Systolic BP increases and diastolic BP decreases after administration of both drugs. There was no significant change observed in Serum Na+ level after...
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Posted by admin on Jun 1, 2013 in |
Carotenoids are accessory coloring pigments found occurring naturally in the plants and some photosynthetic organisms. Recently there has been an increased focus on the health benefits and food applications of these natural pigments. The stability and bioavailability of carotenoids vary significantly across a range of processing paradigms. The present study was planned to investigate stability of carotenoids (β-carotene, lutein and lycopene) subjected to different ranges of temperature and light. It concluded that most stable extract under light is marigold followed by tomato and least stable is carrot. Marigold extract (lutein) is most heat stable followed by tomato extract (lycopene) then carrot extract (β-...
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