Posted by admin on May 1, 2013 in |
The present study was carried out to determine the presence of phytocomponents in the aerial parts of Cleome burmanni using Gas Chromatography- Mass Spectrometry (GC-MS) analysis. The mass spectrum of the crude chloroform extract was compared with the available library sources (NIST08 LIB, WILEY8 LIB). Sixteen components were identified. Sterols, terpenoids and hydrocarbons were the most prominent. The major components detected were 24(s)- Ethyl-3- alpha, 5-alpha-cyclocholest-22 (E)-en-6-one (19.29%), Delta-4-Sitosterol-3-one (14.75%), Cholest-4-en-3-one (12.35%), Stigmasta-5, 23-Dien-3-ol, (3-beta) (12.17%), Neophytadiene (6.83%), Hexatriacontane (6.22%), 1-alanine, N-(3-fluorobenzoyl) – undec-10-enyl ester (5.96%), phytol (5.67%), tetracontane (4.30%), 1,2- benzenedicarboxylic acid (3.25%). The other components were present in minute...
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Posted by admin on May 1, 2013 in |
Escalating social evil and global problem for pharmaceutical scientist world-wide is counterfeiting of drugs. Fraudulent representation of medication with an intention to deceptively represent its origin, authenticity and effectiveness is a counterfeited faked drug which is a potential massacre. The prominent role of drug is patient life-saving, but a drug being counterfeit encounters additive danger to patient. Global scenario indicates India accounts for one third of counterfeit drugs world-wide, being existence since 1982. It is spreading its roots in top most selling drugs like steroids, anticancer etc. This review provides an insight into the planning of counterfeit-free world by implementation of WHO guidelines, updating training programs for pharmacist, adapting innovating methods. The counterfeiters use sophisticated technology for huge profit and less trade risking for counterfeiting of drugs. This difficult task can be overcome by different diagnostic patterns like digital imaging, radio frequency identification (RFID), holographic labels, infra-red inks, supply chain tracking, chemical fingerprints. Inspite of increasing globalization and cross border trading, pharmacists play a major role in curbing the...
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Posted by admin on May 1, 2013 in |
Background: Maternal mortality is one of the indicators in the millennium development goal that is raising concern in achieving the set target of reducing the rate by three-fourth by 2015. Women who die due to pregnancy-related causes are in the prime of their lives and are responsible for the health and well-being of their families. Objective: To assess patterns of maternal mortality and associated factors: at public hospitals in Tigray region, Ethiopia, 2010-2012. Methods: A hospital based case control study was done from May 2012 to December 2012 at public hospitals found in Tigray regional state. Cases were mothes who died in hospital between July, 2010 to June, 2012 and controls were mothers who gave birth in the same hospital during same period. Simple random sampling method was used to select the case and controls. A ratio of four controls to one case was considered to assure sufficient sample size. Data were entered, cleared and analyzed using SPSS window 16. Bivariate analysis was used to determine an association between...
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Posted by admin on May 1, 2013 in |
In the present study an attempt has been made to prepare fast dissolving tablets of Sumatriptan Succinate to improve dissolution rate of the drug in oral cavity & hence better patient’s compliance & effective therapy. Sumatriptan Succinate is a 5-HT1D (5-hydroxy tryptamine 1D) receptor agonist, used in the treatment of migraine and cluster headache. It has low bioavailability due to its first pass metabolism. Hence the main objective of the study was to formulate fast dissolving tablets of Sumatriptan succinate to achieve a better dissolution rate and further improving the bioavailability of the drug. Fast dissolving Sumatriptan succinate was prepared using superdisintegrants Crospovidone, Croscarmellose Sodium, and Preglatinised Starch using the direct compression method. The tablets prepared were evaluated for Thickness, Uniformity of weight, Drug content, Hardness, Friability, Wetting time, in vitro and in vivo disintegration time, in vitro drug release. The formulation F3 containing Crospovidone (8%) was found to give the best result since it showed enhanced dissolution, which leads to improved bioavailability, improved effectiveness and hence better patient...
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Posted by admin on May 1, 2013 in |
Appropriate technology transfer is both integral and critical to drug discovery and development for new medicinal products and is also important to upgrade drug quality designed during research and development and to final product during manufacturing as well as to assure stable quality transferred. Successful development and commercialization of innovative technologies is always fraught with difficulties, multifaceted endeavour, and a variety of development tools exist to promote this activity, by far the most popular approach to directly promoting successful innovation is through technology transfer. To successfully and simultaneously develop appropriate clinical good manufacturing practice facilities, specify and design specialized process equipment, finalize process details, and correctly determine scale-up parameters requires the integrated efforts of a highly skilled technology transfer team. Successful technology transfer requires carefully studying numerous situations like careful evaluation of ultimate manufacturing requirements early in research and development and the consequent development of robust processes that withstand large-scale operation, the assembly of a detailed technology transfer document that provides manufacturing with both “know how” and “know why,”...
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