Posted by admin on May 1, 2013 in |
There are up to 25000 genes encoded by our genome however among them only some are being expressed on mass level. Some of these important genes are; ABO genes located at chromosome number 9, ALB genes located at chromosome number 4, BCL-2 genes located at chromosome number 18, CCR-5 genes located at chromosome number 3, CD4 genes located at chromosome number 12, CD8 genes located at chromosome number 2, IL10 genes located at chromosome number 1, IL2 genes located at chromosome number 4 and INS genes located at chromosome number 11. These above mentioned genes are important in the proper functioning of the body and any mutation in them could lead to different genetic...
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Posted by admin on Apr 1, 2013 in |
Camellia sinensis and Citrus sinensis are treasuries of medicinal properties. The compounds present in these plants can deliver potential therapeutic drug. Most of the drugs in clinical development fail to commercialize because of poor ADME and toxicity properties. The main aim of the study is pharmacokinetic investigation and toxicity property, the most causes of high attrition rates in drug development and it should be considered as early as possible in the drug discovery...
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Posted by admin on Apr 1, 2013 in |
Plants rich in antioxidants and phytochemicals especially phenolic groups play a protective role in health and disease conditions, like cancer, diabetes, heart disease hypertension etc. by counteracting reactive oxygen species and inhibiting the lipid oxidation. Morus indica is non-toxic natural therapeutic plant used as herbal medicine as hypoglycemic, hypotensive, and diuretic properties. In the present study proximate, phytochemical and antioxidant profile in dehydrated leaves powder of Morus indica varieties, M5, V1 and S36 were estimated. The 100% methanol, 80% methanol (methanol & water, 8: 2), dechlorophyllised, aqueous cold and hot extracts were prepared and their polyphenol content, antioxidant activity of inhibiting oxidation in oil emulsion and liver microsomes was evaluated at 300 to 500µg. There was no significant (P<0.05) difference in the moisture, fat and ash content. All the three samples were found to be good sources of major minerals viz. Iron, Calcium phosphorus and also of trace elements like manganese, zinc, copper, potassium.S36 found to be rich in phytochemicals and antioxidants. The polyphenol content was in the order...
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Posted by admin on Apr 1, 2013 in |
The aim of the present investigation is to formulate and evaluate Tizanidine hydrochloride sustained release pellets. Tizanidine hydrochloride is an immadazole α2-adrenergic agonist used in the management of increase in muscle tone associated with spasticity. It has short biological half-life of 2- 2.5 hrs and is rapidly eliminated from the body. Sustained release dosage form of Tizanidine hydrochloride was developed for reduction in total amount of dose administration, to improve patient compliance, and increase efficiency in the treatment. The pellets were prepared by pan coating and fluidized bed coating technique (Wurster type) using hydroxy propyl methyl cellulose E5 (HPMC E5), Ethyl cellulose N-50, Eudragit L-100 as polymers and Isopropyl alcohol, Methylene dichloride as solvents. The pellets are filled in capsules and evaluated for weight variation, content uniformity, moisture content, lock length, disintegration and in-vitro dissolution tests and the results were found to be within the limits. A comparative study of dissolution profile of different batches with marketed product was performed. The optimized batch showed good similarity with the marketed...
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Posted by admin on Apr 1, 2013 in |
A simple and sensitive spectrophotometric method has been developed for the determination of Clomipramine in bulk and tablet dosage forms. The method was based on the charge transfer reactions of Clomipramine with 2, 3-dichloro-5, 6-dicyano-1, 4-benzquinone. The absorbance of the highly intensive coloured solution was measured at 470 nm against reagent blank treated similarly. Beer’s law is obeyed in the concentration range of 50-250 μg/ml. Statistical analysis proves that the proposed method is reproducible and selective for the routine analysis of pharmaceutical formulations of...
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