Posted by admin on Apr 1, 2014 in |
AIDS, a pandemic disease caused by HIV has a high mortality rate. Therapeutic failures have risen due to the emergence of resistant viral strains and adverse side-effects of Anti-HIV drugs. Thus, there arises a need to develop novel and promising anti-HIV drugs. BMS-378806 (BMS-806) inhibits the initial stages of HIV-1 infection by blocking the binding of viral gp120 protein to host-cell CD4 receptor. Protein- Ligand interaction plays a major role in structure-based drug designing. In this study, analogs of BMS-378806 drug for HIV target protein gp120 were virtually designed using Marvin Sketch 4.1.10 and molecular docking studies were carried out using HEX 4.1 docking software. From the results, it was observed that, analog-6 showed better binding affinity to gp120 with Etotal = -102.67 than the original BMS-378806 drug, thus indicating that this compound might be considered as a potential drug candidate against gp120 for controlling HIV-1 infection. Further studies need to be carried out to evaluate the pharmacological efficacy of these...
Read More
Posted by admin on Apr 1, 2014 in |
Solid lipid nanoparticles (SLN) have been reported to be an alternative system to emulsions, liposomes, microparticles and their polymeric counterparts for various application routes since the early 1990s due to their advantages. Solid lipid nanoparticles colloidal drug carrier system gained a lot of popularity among researcher as colloidal drug carriers for incorporating hydrophilic or lipophilic drugs. Solid lipid nanoparticles are the rapidly developing field of nanotechnology with several potential applications in drug delivery, clinical medicine and research, as well as in other varied sciences. Due to their unique size-dependent properties, lipid nanoparticles offer the possibility to develop new therapeutics. The present review focuses on the utility of SLN in terms of their introduction, advantages, disadvantages, general ingredients used, production methodology, characterization and current...
Read More
Posted by admin on Apr 1, 2014 in |
Spondias pinnata is a well-known plant indigenous to South East Asian countries. The plant has been used intensively in many traditional herbal medicines across the globe. This plant has been known to possess antimicrobial, anti-diabetic, ulcer-protective, anti-cancerous, anti-diarrhoeal, anthelmintic, cytotoxic and hepatoprotective activity. It has also been reported that different parts of the plant is used as anti-thirst, anti-emetic and as an anti-tubercular agent. It owes its different pharmacological activities to the wide range of phytoconstituents that are present in the plant. The plant is found to contain sterols, flavonoids, polysaccharides and gums. β-amyrin, oleanolic acid and amino acids—glycine, cystine, serine, alanine and leucine, daucosterol, cycloartanone 24-methylene and lignoceric acid, ellagitannins, galloylgeranin, lignoseric acid and β –carotein are the other constituents that are found to be present in the plant. An attempt has been made to compile these phytoconstituents studies and the different ethnomedicinal and pharmacological properties of Spondias pinnata and provide a full-fledged review in a single document. This review emphasizes the need for more extensive research and...
Read More
Posted by admin on Apr 1, 2014 in |
Niosomes, an emerging class of novel vesicular systems, are non-ionic surfactant vesicles which can entrap both hydrophilic and lipophilic drugs. Niosomes are incorporated into in situ gels for sustained release of drug and to prolong the residence time. The aim of present study is to formulate and evaluate ocular niosomal in situ gels of Linezolid. Linezolid is a potent synthetic oxazolidinone derivative active against a broad range of gram positive and gram-negative aerobic and anaerobic bacteria. Niosomes were prepared using various surfactants (span 20, span 40, span 60 and span 80) in different ratios using thin film hydration technique. They were evaluated for particle size, entrapment efficiency and in vitro drug release. Niosomes prepared using cholesterol and span 60 in the ratio 1:2 showed higher entrapment efficiency and better in vitro drug release. The optimized formulation was formulated as in situ gels using Carbopol 971P and HPMC K4M in different ratios and evaluated for gelling capacity, pH, viscosity, in vitro drug release, drug content, antimicrobial activity and ocular irritation...
Read More
Posted by admin on Apr 1, 2014 in |
Cutaneous leishmaniasis (CL) is a public health problem in Syria call for this parasite’s epidemiological and evolutionary investigation. Evaluation of its population structure by multilocus enzyme electrophoresis (MLEE), current gold standard for classification, has some drawbacks ,such as the lack of discriminatory power below species level, it is labour intensive and time-consuming. In this study , MLEE has been replaced by applying PCR-RFLP of the internal transcribed spacer 1 (ITS1) for identification of leishmania at species level, on 37 samples were obtained from patients with suspected CL referred to Damascus Dermatology Hospital, 19 of them from Damascus and 18 from Aleppo. Intraspecific variation could be detected by the use of 9 hypervariable microsatellite markers. Our results showed that all samples were L. tropica. 26 genotype were detected, of wich 20 were unique to individual strains and 6 were shared by more than sample. Results also showed that there was amoderate genetic differentiation and a clear genetic flow between Aleppo and Damascus. In conclusion, in the present study, the first...
Read More
