PATHOPHYSIOLOGICAL STATUS OF SERUM ANTIOXIDANT, MACRO-MINERALS AND TRACE ELEMENTS IN PATIENTS WITH METABOLIC SYNDROME IN BANGLADESH
This study was undertaken to elucidate the serum antioxidant (Vitamin C), macro - minerals (Ca, Na, and K) and trace elements (Zn, Fe) concentration of in patients with metabolic syndromes. Metabolic syndrome was examined by following the definition developed by the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATPIII). Serum Vitamin C was estimated by phenyl-hydrazine spe...
ANTIHYPERTENSIVE EFFICACY OF ROUWOLFIA TETRAPHYLLA – ROOT OF THE PLANT ON UNINEPHRECTOMIZED DOCA – SALT HYPERTENSIVE RATS
The plant Rouwolfia tetraphylla has been used traditionally as antihypertensive and has been proven scientifically to possess high antioxidant and hepato-protective activity. This study was designed to check the potential of medicinal plants in treatment of hypertension which will be helpful to reduce the side and adverse effect of allopathic antihypertensive drugs. During the experimental period,...
Some biogenic amine like Histamine, cadaverine and putrescine have been confirmed as useful chemical indicators to estimate bacterial spoilage of foods, particularly fish and fish products, cheese, meat and fermented foods. Histamine is toxic at high intakes, while cadaverine and putrescine potentiate the effects of Histamine. Histamine has regulated level of 200 mg/kg (200 ppm). Basic princ...
Metals are able to form a large number of oxides. These metal oxides play an important role in many areas of chemistry, physics and material science. An important metal oxide known as magnesium oxide (MgO) having good reactivity is widely used in producing electronics, catalyst, ceramics, oil, paint etc. Magnesium oxide nanoparticle is non-toxic and need a small amount, so it is suitable for the d...
MUCOADHESIVE MICROPARTICLES OF CARBOXYMETHYL CHITOSAN FOR SITE SPECIFIC DELIVERY OF PANTOPRAZOLE: FORMULATION AND IN VITRO CHARACTERIZATION
Carboxymethyl chitosan, a water soluble modified carboxymethyl substituted chitosan derivative have distinct and unique properties, rendering them effective to form selective permeable mucoadhesive film or membranes. In the formulation of chitosan microsphere an acidic environment is essentially required that may degrade acid sensitive moiety, peptide or protein drugs. Mucoadhesive microparticle o...
SYNERGISTIC OLIGODYNAMIC EFFECT OF MYCOGENIC BIMETALLIC NANOPARTICLES WITH DAPTOMYCIN FOR CONTROLLING PATHOGENS
Bimetallic nanoparticles have several useful opto-electronic and catalytic properties that are different from those of monometallic nanoparticles. The development of non-toxic and eco-friendly protocols for the synthesis of bimetallic nanoparticles is a still less explored area. In the present study, bimetallic silver-gold nanoparticles were synthesized using Trichoderma reesei (NCIM 992). An effe...
Organisms containing integrated sequences of cloned DNA (transgenes), transferred using techniques of genetic engineering (to include those of gene transfer and gene substitution) are called transgenic animals. The development of transgenic animals has been part of biotechnology research which has been expanding rapidly. Transgenic animals produced with the purpose of producing better and good qua...
The aim of the present work is to develop and evaluate colon targeted drug delivery of satranidazole for an effective and safe therapy of amoebiasis. Amoebiasis is a parasitic disease caused by E. histolytica and it causes about 34 - 50 million symptomatic infections each year. The treatment of amoebiasis is effective with satranidazole. Therefore it was planned to develop a suitable dosage form, ...
SYNTHESIS AND BIOLOGICAL ACTIVITY OF SOME NOVEL IMIDAZOLIDINE ANALOGUES AS POTENT ANTIDIABETIC AGENT
Imidazolidine are five-member heterocyclic compounds having two nitrogens in the ring. There are two carbonyls in the ring, one of them between the two nitrogens. The five positions of the ring are numbered and, as such, there are four points of functionality, one at the 1 position, one at the 3 position and two at the 5 position in their ring structure respectively and thus exhibiting potent as w...
Rapid, sensitive, specific and validated colorimetric methods have been developed for the quantitative estimation of ambroxol HCl in bulk and dosage form. The current method was developed based on oxidation of ambroxol with Gibb’s reagent (method I) and p-diethyl amino benzaldehyde in toluene (method II). The formed intense colour complex was measured at 537.2 nm and 438.4 nm respectively. Under...