Acetylcholine satisfies all criteria for a transmitter substance. Its most widely recognized action sites are the endings of vertebrate motor nerves, the endings of the automatic pre ganglionics and the parasympathetic post ganglionics. It appears also to be the transmitter of motor nerves in all advanced invertebrate animals except the arthropods where it seems to separate at the endings of senso...
AIDS, a pandemic disease caused by HIV has a high mortality rate. Therapeutic failures have risen due to the emergence of resistant viral strains and adverse side-effects of Anti-HIV drugs. Thus, there arises a need to develop novel and promising anti-HIV drugs. BMS-378806 (BMS-806) inhibits the initial stages of HIV-1 infection by blocking the binding of viral gp120 protein to host-cell CD4 recep...
Studies on plant secondary metabolites have been increasing over the last 70 years. These molecules are known to play a major role in the adaptation of plants to their environment, but also represent an important source of active pharmaceuticals. Role of primary metabolites in basic life functions such as cell division and growth, respiration, storage, and reproduction have been described in moder...
Bryophyllum pinnatum is widely used in ayurvedic system of medicine as astringent, analgesic, carminative and also useful in diarrhoea and vomiting. It is naturalized throughout the hot and moist parts of India. The leaves of B. pinnatum have a variety of uses in the traditional system of medicine in India. They are eaten for diabetes, diuresis, dissolving kidney stones, respiratory tract infect...
Currently there has been an increased interest in using iontophoretic technique for the controlled transdermal drug delivery of medicines, especially in the delivery of proteins & peptides through skin membranes. The delivery of ionic drug molecules and peptide/protein molecules through transdermal delivery to attain a systemic therapeutic effect, chemical or physical methods are needed to imp...
Objective: The current study was designed to study Acute Dermal Irritation potential of Mastilep gel (supplied by M/S Ayurvet Limited, Baddi, India) according to OECD guidelines. Materials and Methods: Mastilep gel, a new herbal ointment for topical use applied on the udder, has been developed as an alternative method for controlling mastitis in ruminants. Mastilep gel’s active ingredients inclu...
MEMBRANE SENSORS FOR THE SELECTIVE DETERMINATION OF TOLTERODINE TARTRATE IN PRESENCE OF ITS DEGRADATION PRODUCT
The construction and electrochemical response characteristics of polyvinyl chloride (PVC) membrane sensors for determination of Tolterodine tartrate (TT) in presence of its oxidative degradation product are described. The sensors are based on the ion association complexes of TT cation with sodium tetraphenyl borate (TT-TPB) [sensor 1] or phosphomolybidic acid (TT-PMA) [sensor 2] counter anions as ...
Objective: To investigate the patient’s knowledge of hypertension fact with validated Morisky questionnaires and management of drug adherence. Materials and methods: The aim of one present study was undertaken 100 patients attending the cardiology, outpatient department in various private sector hospitals in southern Tamilnadu and to assess the patient’s medication knowledge and drug adheren...
PHYTOCHEMICAL SCREENING AND ANTIOXIDANT ACTIVITY OF LEAVES AND STEM BARK EXTRACTS OF GARCINIA IMBERTI – AN ENDANGERED PLANT
Garcinia imberti Bourd. a critically endangered tree belongs to the family Clusiaceae found only in India. The phytochemicals and antioxidant studies were carried out for the methanolic extracts of Garcinia imberti leaves and stem bark using DPPH and ABTS radical scavenging assay. Preliminary phytochemical screening of methanolic extracts of Garcinia imberti revealed the presence of various bioact...
METAPHORICAL QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP (2D & 3D-QSAR) ANALYSIS OF TYLOPHORINE DERIVATIVES AS EFFICACIOUS IN ANTIMALARIAL DRUG DESIGN
Quantitative Structure Activity Relationship (QSAR) for tylophorine derivatives acting as Plasmodium kinases inhibitors has been developed. The proposed 2D-QSAR model was found to be statistically significant with respect to training, cross-validation, and external validation.The contribution of carbon chains with aromatic and electronegative features are found to be the most important descriptors...