STUDY OF NEUTRALIZATION OF ENZYMATIC ACTIVITY OF DABOIA RUSSELII VENOM BY VARIOUS PLANT EXTRACTS AND THEIR COMBINATIONS USING IN VITRO METHODS
Snakebite is an important cause of morbidity and mortality and is one of the major health problems in India. Russell’s viper (Daboia russelli) appears to be the commonest cause of fatal snakebite in many Asian countries and especially in the Indian subcontinent. Intravenous administration of anti venom serum neutralizes the systemic actions, but it is of little effect on the reversal of local sy...
Azetidin-2-one analogues are reported to exhibit various pharmacological activities like cholesterol absorption inhibitory activity, human tryptase, thrombin and chymase inhibitory activity, vasopressin V1a antagonist activity, antidiabetic, anti-inflammatory, antiparkinsonian and anti-HIV activity in addition to antimicrobial.1-6 In the present study, Isoniazid (INH), the established antituberc...
STUDY OF DRUG PRESCRIBING PATTERNS IN PSORIASIS AND ASSESSMENT OF RATIONALITY USING SIGN AND NICE GUIDELINES AT A TERTIARY CARE TEACHING HOSPITAL
Introduction: Psoriasis is a chronic inflammatory disease of high prevalence. In India the prevalence of psoriasis varies from 0.44 to 2.8%. The main aim of drug utilization research is to facilitate the rational drug use. Without a precise knowledge of how drugs are being prescribed and used, it is difficult to suggest measures to improve the prescribing habits. The economic burden of psoriasis i...
THE EFFECT OF HYRDRAZIDE GROUP ON THE OXYDATION OF FERROCENE AT TWO DIFFERENT ELECTRODES USING ROTATING DISK ELECTRODE (RDE) IN ORGANIC MEDIUM
Through this work we adopted Rotating Disk Electrode (RDE) Voltammetry to study the kinetics of oxidation and the effect of hydrazide group on ferrocene in organic medium. Thus, two different electrodes (Pt and Gc) were used in ordre to determine this latter. According to the ferrocene taken as a witness the hydrazide group related to the ferrocene made oxydation more difficult. This ferrocenic de...
Although the antioxidant and thrombolytic potential of the “super fruit” pomegranate has been well established and documented in in vitro models, its efficacy in an animal model has not been recognised. Therefore in the present study, the aril and rind of Punica granatum were scrutinized for their role in clot lysing competence in a thrombus induced rat model. Visual manifestation, coagulation...
IN SILICO DRUG DOCKING OF PHYTO INHIBITORS AGAINST TRIOSEPHOSPHATE ISOMERASE IN PLASMODIUM FALCIPARUM
Malaria caused by the parasite Plasmodium falciparum is a major public health concern. The parasite lacks a functional Tricarboxylic acid cycle (TCA), making glycolysis its sole energy source. One such enzyme is triose phosphate isomerase. This catalyzes the isomerization of D-Glyceraldehyde 3 phosphate to dihydroxy acetone phosphate. An attempt was made to identify the potential phyto inhibitor...
EFFECTIVENESS OF ANTIBIOTICS IN INCREASING THE FUNCTIONAL CAPACITY AND REDUCING THE ECONOMIC BURDEN IN FEMALE URINARY TRACT INFECTION PATIENTS
Background: Urinary tract infection is a common medical problem for women throughout their lifetime. Recurrence after urinary tract infection (rUTI) is common in adult women. The majority of recurrences are believed to be reinfection from extra urinary sources such as rectum or vagina. The treatment of recurrent urinary tract infection also inflicts an economic burden on the patient’s life. Henc...
Candesartan Cilexitil is an angiotensin II receptor antagonist used mainly for the treatment of hypertension. Candesartan cilexitil is a BCS class II drug having low solubility and high permeability. Candesartan Cilexitil is a prodrug which is rapidly converted to the active drug, Candesartan, by ester hydrolysis during absorption from the gastrointestinal tract. The bioavailability of Candesartan...
BELINOSTAT: A HISTONE DEACETYLASE INHIBITOR FOR THE TREATMENT OF PATIENTS WITH RELAPSED OR REFRACTORY PERIPHERAL T-CELL LYMPHOMA
Histone deacetylase inhibitors (HDACIs) are a group of agents that have exhibited antitumor activity in vivo and in vitro, directing to clinical trials estimating their efficacy in multiple cancer types. Belinostat is under global development with Spectrum Pharmaceuticals, currently approved by the U.S. Food and Drug Administration with indications for relapsed or refractory peripheral T-cell lymp...
STUDIES ON ABOVE GROUND BIOMASS (AGB) FOR ASSESSING VEGETATION CARBON POOL IN TROPICAL FOREST ECOSYTEM OF CENTRAL INDIA
For estimation of carbon stocks in tropical forest types belonging to southern part of Madhya Pradesh, 30 adopted representative sites comprising eight districts viz, Jabalpur, Seoni, Balaghat, Narsinghpur, Mandla, Dindori, Shahdol and Umaria were selected for study and studies were carried out during 2009 to 2011. The study covered three types of vegetation i.e. teak mixed forest, sal mixed fores...