ENHANCEMENT OF DISSOLUTION RATE AND FORMULATION DEVELOPMENT OF RITONAVIR TABLETS EMPLOYING STARCH PHOSPHATE- A NEW MODIFIED STARCH
The objective of the study is to prepare, characterize and evaluate starch phosphate, a new modified starch as a carrier in solid dispersions for enhancing the dissolution rate of ritonavir. The feasibility of formulating solid dispersions of ritonavir in starch phosphate into compressed tablets with enhanced dissolution rate was also investigated. Starch phosphate was prepared by reacting star...
VARIATIONS IN PHENOLICS, ANTIOXIDANT AND PHYTOCHEMICAL COMPOSITION OF SALVADORA PERSICA IN TWO LOCATIONS
Phenolic extracts of crude oil and methanol extracts of defatted seed cake were used to evaluate total phenolics, flavonoids content and antioxidant activity for two locations. The seeds were evaluated for their proximate composition while oils were subjected to chemical analysis. Salvadora persica had highest phenolics ranged from 12.3 ± 0.3 to 22.3 ± 0.3mg GAE/g and flavonoids content 3.7 ± 0...
Benzimidazoles are an important class of compounds with a wide spectrum of biological activity ranging from anti-hypertensive, anti-viral, anti-fungal, antitumor and anthelmintic activity. Benzimidazole rings are the most important nitrogen-containing heterocycles, which are widely explored and utilized by the pharmaceutical industry for drug discovery. Due to their special structural features and...
Antibiotic efflux pumps appear a major component of microbial resistance to many classes of major antibiotics namely the tetracycline, the macrolides, and the fluoroquinolones. These are totally synthetic, amphiphilic compounds with no known ‘natural’ counterpart, antibiotic efflux appears sufficient per se to confer a medium or high level of resistance, defeating medically applicable treatmen...
A NOVEL HPLC METHOD FOR THE SIMULTANEOUS DETERMINATION OF CHLORPHENIRAMINE MALEATE AND DEXTROMETHORPHAN IN BULK AND PHARMACEUTICAL FORMULATION
Chlorpheniramine maleate and Dextromethorphan are used in treatment of cough caused by allergies and the common cold by decreasing intra ocular pressure. The present study was designed to develop and validate a simple, sensitive, precise and accurate reverse phase high performance liquid chromatographic (HPLC) method for simultaneous determination of Chlorpheniramine maleate and Dextromethorphan i...
In this article, we have reviewed several features of nanomicelles relating to their general properties, preparation and characterization techniques, and their applications in the areas of ocular drug delivery system. Nanomicelles can be rummage-sale as 'smart drug carriers' for targeting certain areas of the eye by making them stimuli-sensitive or by attachment of a specific ligand molecule onto ...
ANTIBACTERIAL ACTIVITY OF HEXANIC EXTRACT OF RUTA GRAVEOLENS ON KLEBSIELLA PNEUMONIAE- A COMMON POST- ORTHOPEDIC SURGERY INFECTION
Introduction: Klebsiella pneumoniae is one of the most frequent infection organism following orthopedic surgeries and specifically total hip arthroplasty. Recently, attitude toward herbal medicine is being popular both in people and health care systems. Ruta graveolens is a traditional herbal remedy Iranian medicine and some other countries with a wide spectrum of therapeutic utilities. Our purpos...
Objective: To determine the incidence, characteristics, predictors and cost associated with the management of adverse drug interactions (ADIs) in elderly population. Methods: The prospective, intensive and interventional study included all patients taking at least two medications who were elderly admitted to medicine or surgery wards of a tertiary care hospital and were followed untill discharge. ...
Introduction: Antibiotics are used to perish the growth of bacteria. Undesirable use of antibiotics is presently common all over the world. Parent’s knowledge and attitudes towards antibiotics play a vital role in the success of treatment process. Due to lack of knowledge, sometimes antibiotics are badly used for the treatment of infection. Study aims to evaluate the knowledge, attitude and prac...
IN-VITRO BIOLOGICAL ACTIVITIES OF FRACTIONS OF ETHYL ACETATE FRACTION OF THE WATER EXTRACT OF ARTOCARPUS HETEROPHYLLUS SENESCENT LEAVES
Artocarpus heterophyllus belongs to the family Moraceae. In Sri Lankan traditional medicine the water extract of A. heterophyllus senescent leaves is used to control diabetes mellitus. The hypoglycemic activity of ethyl acetate fraction of water extract of senescent leaves has been reported. Ethyl acetate fraction (EA/W) was fractionated using sephadex LH-20 column chromatography using the solvent...